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MAPK signaling pathways in the regulation of hematopoiesis
Journal of Leukocyte Biology, 2009Abstract Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an essential role in connecting cell-surface receptors to changes in transcriptional programs.
Christian R, Geest, Paul J, Coffer
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The MAPK signalling pathways and colorectal cancer
The Lancet Oncology, 2005There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-
Jing Yuan, Fang, Bruce C, Richardson
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Selaginellin Inhibits Melanogenesis via the MAPK Signaling Pathway
Journal of Natural Products, 2022Hyperpigmented skin diseases such as melasma, freckles, and melanosis usually mar the appearance of patients. Traditional herbal medicines are highly accepted in inhibiting skin pigmentation, with advantages of high efficiency, low cost, and low side effects.
Ying Zhou +15 more
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Allosteric activation of RAF in the MAPK signaling pathway
Current Opinion in Structural Biology, 2018Protein kinases are evolutionarily crafted into two functional states. In response to stimuli, kinase, which is usually populated in an inactive state, becomes active. Here, we outline a unified scheme to explain how kinases are activated physiologically and pathologically, focusing on RAF allosteric activation.
Chung-Jung, Tsai, Ruth, Nussinov
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The Ras-MAPK Signal Transduction Pathway
Science Signaling, 2010Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
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MAPK Signaling Pathways and Their Recursive Modularization
2006 15th International Conference on Computing, 2006Signal transduction pathways are very complex biochemical networks that include a large number of vital biomolecules and chemical compounds whose activities are dependent on member(s) involved in the network under consideration as well as other networks.
Rajat De, Losiana Nayak
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Role of lipids in the MAPK signaling pathway
Progress in Lipid Research, 2006The mitogen-activated protein kinase (MAPK) signaling pathway is activated in response to a variety of extracellular stimuli such as growth factor stimulation. The best-characterized MAPK pathway involves the sequential activation of Raf, MEK and ERK proteins, capable of regulating the gene expression required for cell proliferation.
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High-throughput approaches to dissecting MAPK signaling pathways
Methods, 2006With the development of genome-wide RNAi libraries, it is now possible to screen for novel components of mitogen-activated protein kinase (MAPK) pathways in cell culture. Although genetic dissection in model organisms and biochemical approaches in mammalian cells have been successful in identifying the core signaling cassettes of these pathways, high ...
Friedman, A., Perrimon, N.
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State machine modeling of MAPK signaling pathways
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and
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MAPK signaling pathways in eye wounds: Multifunction and cooperation
Experimental Cell Research, 2017As is widely distributed in eukaryotic cells, the mitogen-activated protein kinase (MAPK) signaling pathway family plays an inevitable role in diverse cellular processes, being capable of responding to particular physiological reactions induced by multiple extracellular signals or stimuli, such as protean concentrations, ischemia/reperfusion, and ...
Boyuan, Yao +5 more
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