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The MAPK signalling pathways and colorectal cancer
The Lancet Oncology, 2005There are three major subfamilies of mitogen-activated protein kinases (MAPK): the extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress-activated protein kinases (JNK or SAPK); and MAPK14. The ERK MAPK pathway is one of the most important for cell proliferation. The MAPK pathways are located downstream of many growth-
Jing Yuan, Fang, Bruce C, Richardson
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MAPK signaling pathways in the regulation of hematopoiesis
Journal of Leukocyte Biology, 2009Abstract Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an essential role in connecting cell-surface receptors to changes in transcriptional programs.
Geest, C.R., Coffer, P.J
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MAPK signaling pathway-targeted marine compounds in cancer therapy
Journal of Cancer Research and Clinical Oncology, 2021This paper reviews marine compounds that target the mitogen-activated protein kinase (MAPK) signaling pathway and their main sources, chemical structures, major targeted cancers and possible mechanisms to provide comprehensive and basic information for the development of marine compound-based antitumor drugs in clinical cancer therapy research.This ...
Jiaen Wei +5 more
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The Ras-MAPK Signal Transduction Pathway
Science Signaling, 2010Animated lessons illustrate a canonical signaling pathway activated by various hormones and growth factors.
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High-throughput approaches to dissecting MAPK signaling pathways
Methods, 2006With the development of genome-wide RNAi libraries, it is now possible to screen for novel components of mitogen-activated protein kinase (MAPK) pathways in cell culture. Although genetic dissection in model organisms and biochemical approaches in mammalian cells have been successful in identifying the core signaling cassettes of these pathways, high ...
Friedman, A., Perrimon, N.
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State machine modeling of MAPK signaling pathways
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2014Mitogen activated protein kinase (MAPK) signaling pathways are frequently deregulated in human cancers with potential involvement in most if not all cellular processes leading to tumorigenesis. Mathematical/computational models of MAPK signaling are indispensable to the study of pathway deregulation dynamics and their nonlinear effects on cell fate and
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MAPK Signaling Pathways and Their Recursive Modularization
2006 15th International Conference on Computing, 2006Signal transduction pathways are very complex biochemical networks that include a large number of vital biomolecules and chemical compounds whose activities are dependent on member(s) involved in the network under consideration as well as other networks.
Rajat De, Losiana Nayak
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ErbB4 regulate extracellular dopamine through the p38 MAPK signaling pathway
Neuroscience Letters, 2021ErbB4 loss-of-function in catecholaminergic neurons induces catecholamine dyshomeostasis. Despite ErbB4's significant role in neuropathology, the signaling pathways that regulate these changes are still widely unknown. In this study, we attempt to identify the downstream pathway of ErbB4 that regulates catecholamine homeostasis.
Shu-xia Cao +7 more
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Allosteric activation of RAF in the MAPK signaling pathway
Current Opinion in Structural Biology, 2018Protein kinases are evolutionarily crafted into two functional states. In response to stimuli, kinase, which is usually populated in an inactive state, becomes active. Here, we outline a unified scheme to explain how kinases are activated physiologically and pathologically, focusing on RAF allosteric activation.
Chung-Jung, Tsai, Ruth, Nussinov
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[MAPK signaling pathway and erectile dysfunction].
Zhonghua nan ke xue = National journal of andrology, 2018The MAPK signaling pathway plays a key role in the differentiation, proliferation and apoptosis of cells, and its family members mainly include extracellular signal-regulated kinase (ERK), stress-activated protein kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK). Recent studies have shown that the ERK, JNK and p38MAPK signaling pathways
Si-Xiang, Chen +2 more
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