Results 71 to 80 of about 170,469 (263)

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma [PDF]

, 2016
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF MAPK pathway activation.
Athineos, Dimitris, Barker, Nick, Cammareri, Patrizia, Chelala, Claude, Clevers, Hans, Coates, Philip J ., Dayal, Jasbani, Harwood, Catherine A., Inman, Gareth, Karlsson, Stefan, Larsson, Jonas, Leigh, Irene, Libertini, Silvana, Marais, Richard, McHugh, Angela, Nagano, Ai, Pourreyron, Celine, Pritchard, Catrin, Proby, Charlotte, Purdie, Karin J., Ridgway, Rachel A., Rose, Aidan, Sansom, Owen J., Sapkota, Gopal, South, Andrew, Spender, Lindsay, Vincent, David F., Wang, Jun, Weidlich, Simone   +28 more
core   +4 more sources

Synthetic biology: lessons from engineering yeast MAPK signalling pathways [PDF]

Molecular Microbiology, 2013
SummaryAll living cells respond to external stimuli and execute specific physiological responses through signal transduction pathways. Understanding the mechanisms controlling signalling pathways is important for diagnosing and treating diseases and for reprogramming cells with desired functions.
Furukawa, Kentaro, Hohmann, Stefan
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking

Ecotoxicology and Environmental Safety
The rapid growth of lithium (Li)-related industrial activities and the application of Li-containing products have become an emerging human health concern.
Wei Wei, Siting Pu, Chengxin Yan, Hongzao Yang, Hongwei Chen   +4 more
doaj   +1 more source

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

Serum Response Factor Controls CYLD Expression via MAPK Signaling Pathway [PDF]

PLoS ONE, 2011
Tumor suppressor gene CYLD is a deubiquitinating enzyme which negatively regulates various signaling pathways by removing the lysine 63-linked polyubiquitin chains from several specific substrates. Loss of CYLD in different types of tumors leads to either cell survival or proliferation. In this study we demonstrate that lack of CYLD expression in CYLD-/
Liang, G., Ahlqvist, K., Pannem, R., Posern, G., Massoumi, R.   +4 more
openaire   +6 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Immunolocalization of dually phosphorylated MAPKs in dividing root meristem cells of Vicia faba, Pisum sativum, Lupinus luteus and Lycopersicon esculentum [PDF]

, 2015
Key message In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated MAPKs to mitotic microtubules.
A Bessard, A Neupane, A Neupane, A Pitzschke, AK Sinha, Aneta Żabka, AP Smertenko, D Ortiz-Masia, F Kong, G Komis, G Taj, G Tena, H Nakagami, J Müller, J Schindelin, Janusz Maszewski, Joanna Bernasińska, K Kosetsu, Karolina Matczak, Konrad Winnicki, L Bögre, M Beck, M Beck, M Cargnello, M Fernandez-Pascual, M Ohori, M Ovečka, M Sasabe, M Wrzaczek, MA González Besteiro, MAPK Group, MM Horne, NS Mishra, O Šamajová, PJ Krysan, R Ulm, R Ulm, RM Perrett, T Hayashi, V Smékalová, W Ligterink, X Liu, X Qian   +42 more
core   +2 more sources