Results 61 to 70 of about 16,396 (225)

Crystal Structure of Marburg Virus VP24 [PDF]

Journal of Virology, 2014
ABSTRACT The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not.
Adrianna P P, Zhang, Zachary A, Bornholdt, Dafna M, Abelson, Erica Ollmann, Saphire   +3 more
openaire   +2 more sources

Protein nanoparticles assemble in plants, display antigenic viral peptides, and produce an epitope‐specific immune response

The FEBS Journal, EarlyView.
Current methods to control porcine reproductive and respiratory syndrome, a disease affecting pigs, are insufficient and a safer, more effective vaccine is needed. This study describes the design and plant production of a self‐assembling protein nanoparticle vaccine candidate against this disease.
Jordan T. VanderBurgt, Richard Strasser, Hong Zhu, Angelo Kaldis, Christopher P. Garnham, Rima Menassa   +5 more
wiley   +1 more source

Preimaginal development of Aedes aegypti L. (Diptera: Culicidae) in brackish water gives rise to adult mosquitoes with thicker cuticles and greater insecticide resistance

Medical and Veterinary Entomology, EarlyView.
The principal arboviral vector Aedes aegypti can develop in coastal brackish water field habitats (0.5–15 g/L salt) with larvae possessing thicker cuticles and greater resistance to the larvicide Temephos. Females emerging from brackish water‐developing preimaginal stages are now shown to have thicker and remodelled leg and abdominal cuticles and ...
Kokila Sivabalakrishnan, Andrew Hemphill, S. H. P. Parakrama Karunaratne, Arunasalam Naguleswaran, Isabel Roditi, Sinnathamby N. Surendran, Ranjan Ramasamy   +6 more
wiley   +1 more source

Carbohydrate structure of Marburg virus glycoprotein [PDF]

Glycobiology, 1992
Marburg virus was propagated in E6 cells, a cloned cell line of Vero cells, in the presence of [6-3H]glucosamine. Radiolabelled viral glycoprotein was digested with trypsin, and oligosaccharides were liberated by sequential treatment with endo-beta-N-acetylglucosaminidase H, peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase F and O-glycosidase,
H, Geyer, C, Will, H, Feldmann, H D, Klenk, R, Geyer   +4 more
openaire   +2 more sources

Experimental Success in Marburg Virus Vaccination

Quality in Sport
The Marburg virus (MRV), classified within the Filoviridae family, was initially identified in 1967, precipitating Marburg virus disease (MARV), a severe and often fatal hemorrhagic fever.
Martyna Dydyk, Aleksandra Nowak
doaj   +1 more source

Studies of Reservoir Hosts for Marburg Virus

Emerging Infectious Diseases, 2007
To determine reservoir hosts for Marburg virus (MARV), we examined the fauna of a mine in northeastern Democratic Republic of the Congo. The mine was associated with a protracted outbreak of Marburg hemorrhagic fever during 1998–2000.
Robert Swanepoel, Sheilagh B. Smit, Pierre E. Rollin, Pierre Formenty, Patricia A. Leman, Alan Kemp, Felicity J. Burt, Antoinette A. Grobbelaar, Janice Croft, Daniel G. Bausch, Hervé Zeller, Herwig Leirs, L.E.O. Braack, Modeste L. Libande, Sherif Zaki, Stuart T. Nichol, Thomas G. Ksiazek, Janusz T. Paweska   +17 more
doaj   +1 more source

Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma

International Journal of Cancer, Volume 158, Issue 4, Page 858-865, 15 February 2026.
What's new? Lung adenocarcinoma shows considerable heterogeneity in disease progression and therapeutic response. Here, the authors analyzed tumor samples through proteomic profiling and applied network‐based clustering. They identified two distinct patient groups with different demographic, clinical, and molecular characteristics.
Ujjwal Neogi, Anoop T. Ambikan, Kati Turkowski, Marc A. Schneider, Vanessa M. Beutgen, Johannes Graumann, Hauke Winter, Marek Bartkuhn, Werner Seeger, Soni S. Pullamsetti, Rajkumar Savai   +10 more
wiley   +1 more source

Ultrastructural Organization of Recombinant Marburg Virus Nucleoprotein: Comparison with Marburg Virus Inclusions

Journal of Virology, 2000
ABSTRACT HeLa cells expressing the recombinant Marburg virus (MBGV) nucleoprotein (NP) have been studied by immunoelectron microscopy. It was found that MBGV NPs assembled into large aggregates which were in close association with membranes of the rough endoplasmic reticulum.
L, Kolesnikova, E, Mühlberger, E, Ryabchikova, S, Becker   +3 more
openaire   +3 more sources

Breast Health Training Program for Traditional Healers: A Pathway to Early Breast Cancer Detection in Tanzania

Cancer Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background In sub‐Saharan Africa, traditional healers often serve as primary healthcare providers and are the first point of contact for patients. Given this, they are uniquely positioned to aid in early breast cancer detection. To evaluate this, we implemented a breast cancer training program to equip traditional healers in Tanzania with ...
Autumn Beavers, Elizabeth F. Msoka, Irene Masue, Theresia Mwakyembe Mwansasu, Ayesiga Herman, Blandina T. Mmbaga, Lily Gutnik   +6 more
wiley   +1 more source

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre‐Filled Pen Versus Pre‐Filled Syringe in Healthy Participants

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Garadacimab is a novel, fully human, anti‐activated factor XII monoclonal antibody approved for long‐term prophylaxis of patients with hereditary angioedema. This open‐label, parallel‐group, Phase 1, single‐center, bridging study in healthy adults (18–55 years of age) characterized the pharmacokinetics and safety of a single 200 mg ...
Fiona Glassman, John‐Philip Lawo, Mihai Alexandru Bica, Anthony Roberts, David Kormann, Ligia Chialda, Soeren Miethke, Iwona Dziadowiec, Stephen Caltabiano, Thomas Puchalski   +9 more
wiley   +1 more source