Results 1 to 10 of about 7,198 (164)

Computational Modeling and Evaluation of Potential mRNA and Peptide-Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever. [PDF]

Biomed Res Int, 2023
A hemorrhagic fever caused by the Marburg virus (MARV) belongs to the Filoviridae family and has been classified as a risk group 4 pathogen. To this day, there are no approved effective vaccinations or medications available to prevent or treat MARV infections.
Albaqami FF, Altharawi A, Althurwi HN, Alharthy KM, Qasim M, Muhseen ZT, Tahir Ul Qamar M.   +6 more
europepmc   +7 more sources

Marburg Virus Disease: A Narrative Review [PDF]

Health Science Reports
Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re ...
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
doaj   +4 more sources

Advancements in Marburg (MARV) Virus Vaccine Research With Its Recent Reemergence in Equatorial Guinea and Tanzania: A Scoping Review [PDF]

Cureus, 2023
Given the recent outbreaks of the Marburg (MARV) virus within the first quarter of the year 2023, interest in the MARV virus has been re-ignited given its shared phylogeny with the dreadful Ebola virus. This relation gives some insight into its virulence, associated morbidities, and mortality rates.
Manish P Mane Manohar, Vivian J Lee, Ejikeme U Chinedum Odunukwe, Pratik K Singh, Buhlebethu S Mpofu, Christine Oxley   +5 more
semanticscholar   +4 more sources

Rapid and Durable Protection Against Marburg Virus with a Single-Shot ChAd3-MARV GP Vaccine [PDF]

bioRxiv, 2021
AbstractMarburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans up to 90%. Since 2018, MARV has been identified as a priority pathogen by the WHO, needing urgent research and development of countermeasures due to the high public health risk it poses.
Ruth Hunegnaw, Anna N. Honko, Lingshu Wang, Derick Carr, Tamar Murray, Wei Shi, Caitlyn N M Dulan, Kathryn E. Foulds, Krystle N. Agans, Robert W. Cross, Joan B. Geisbert, Thomas W. Geisbert, Cheng Cheng, Aurélie Ploquin, Daphne A. Stanley, Gary J. Nabel, Nancy J. Sullivan   +16 more
semanticscholar   +3 more sources

Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40

Journal of General Virology, 2009
The VP40 matrix protein of Marburg virus (MARV) has been shown to be the driving force behind MARV budding, a process in which the PPPY L-domain motif of VP40 plays a critical role. Here, we report that Vps4B and Nedd4.1 play critical roles in MARV VP40-mediated budding.
Sarah Urata, Jiro Yasuda
semanticscholar   +4 more sources

DESAIN VAKSIN MULTI-EPITOP TERHADAP VIRUS MARBURG (MARV) BERBASIS PROTEIN VP35 MENGGUNAKAN PENDEKATAN IMMUNOINFORMATIKA: IN-SILICO

Pharmacoscript
Virus Marburg (MARV) merupakan salah satu virus zoonosis dari keluarga Filoviridae dengan tingkat kematian hingga 88%. Pertumbuhan populasi global yang pesat meningkatkan risiko paparan penyakit akibat perubahan iklim dan ekologi. Untuk pencegahan, vaksin menjadi upaya terbaik.
Asopari Ilham Nurfadilah, Pratita Anindita Tri Kusuma, Mardianingrum Richa, Ruswanto Ruswanto   +3 more
semanticscholar   +4 more sources

Rodent adapted marburg viruses are lethal in ferrets [PDF]

npj Viruses
Ferrets are highly susceptible to infection with several orthoebolaviruses, including Ebola virus (EBOV), yet they are refractory to infection with the orthomarburgviruses, Marburg virus (MARV) and Ravn virus.
Zachary Schiffman, Lauren Garnett, Kaylie N. Tran, Jonathan Audet, Kevin Tierney, Kim Azaransky, Shihua He, Logan Banadyga, James E. Strong   +8 more
doaj   +2 more sources

Evaluation of long-term immunity following inoculation with highly diverse orthomarburgvirus isolates in Egyptian rousette bats (Rousettus aegyptiacus) [PDF]

Journal of Virology
Viral coinfections and their impact on long-term immunity represent an understudied area in disease ecology and infectious disease research. Coinfections can influence the host’s susceptibility to future infections, alter host and pathogen population ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +2 more sources

Discovery of potent cross-neutralizing antibodies against Marburg and Ravn viruses with therapeutic potential [PDF]

npj Viruses
Marburg virus (MARV) and Ravn virus (RAVV) are highly pathogenic filoviruses that cause Marburg virus disease (MVD), for which no approved treatment currently exists.
Takeshi Saito, Hiroko Miyamoto, Manabu Igarashi, Asuka Nanbo, Risa Hayashi, Ruchi Paroha, Gavriella Siman-Tov, Kirsten Littlefield, Akina Mori-Kajihara, Christine Click, Wakako Furuyama, Slobodan Paessler, Junki Maruyama, Ayato Takada   +13 more
doaj   +2 more sources

Characterization of Ravn virus viral shedding dynamics in experimentally infected Egyptian rousette bats (Rousettus aegypticus) [PDF]

Journal of Virology
Marburg virus (MARV) and Ravn virus (RAVV), the only two known members of the species Orthomarburgvirus marburgense (family Filoviridae), are causative agents of Marburg virus disease, a severe viral disease that typically emerges in sub-Saharan Africa ...
Jessica A. Elbert, Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Elizabeth W. Howerth, Jonathan S. Towner   +7 more
doaj   +2 more sources