Results 41 to 50 of about 4,442 (181)

Studies of Reservoir Hosts for Marburg Virus

Emerging Infectious Diseases, 2007
To determine reservoir hosts for Marburg virus (MARV), we examined the fauna of a mine in northeastern Democratic Republic of the Congo. The mine was associated with a protracted outbreak of Marburg hemorrhagic fever during 1998–2000.
Robert Swanepoel, Sheilagh B. Smit, Pierre E. Rollin, Pierre Formenty, Patricia A. Leman, Alan Kemp, Felicity J. Burt, Antoinette A. Grobbelaar, Janice Croft, Daniel G. Bausch, Hervé Zeller, Herwig Leirs, L.E.O. Braack, Modeste L. Libande, Sherif Zaki, Stuart T. Nichol, Thomas G. Ksiazek, Janusz T. Paweska   +17 more
doaj   +1 more source

Charakterisierung der Rolle des endosomalen Recycling-Systems für den intrazellulären Transport des Marburg Virus Glykoproteins [PDF]

, 2019
Das Marburg Virus (MARV), das zur Familie der Filoviridae gezählt wird, ist ein Erreger schwerer Fieber mit Letalitätsraten von bis zu 90 %. Das Glykoprotein GP stellt das einzige Oberflächenprotein des MARV dar und daher ist sein korrekter Transport zu ...
Halwe, Sandro
core   +1 more source

Transcriptional profiling of immune responses in NHPs after low-dose, VSV-based vaccination against Marburg virus

Emerging Microbes and Infections, 2023
Infection with Marburg virus (MARV), the causative agent of Marburg virus disease (MVD), results in haemorrhagic disease and high case fatality rates (>40%) in humans. Despite its public health relevance, there are no licensed vaccines or therapeutics to
Cecilia A. Prator, Brianna M. Dorratt, Kyle L. O’Donnell, Justin Lack, Amanda N. Pinski, Stacy Ricklefs, Craig A. Martens, Ilhem Messaoudi, Andrea Marzi   +8 more
doaj   +1 more source

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 [PDF]

, 2012
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%).
A Grolla, A MacNeil, A Tuffs, AJ Georges, AM Casillas, B Jeffs, B Le Guenno, Benjamin Jeffs, BS Hewlett, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DH Smith, DL Heymann, E Mupere, ED Johnson, EM Leroy, EM Leroy, Esther Sterk, GA Martini, GA Martini, JL Conrad, Joseph Wamala, JS Gear, JS Towner, Julius Lutwama, K Kibadi, K Mupapa, K Mupapa, KJ Davis, M Borchert, M Bray, M Bray, MA Bwaka, Malcolm Gracie Semple, Maria D. Van Kerkhove, Matthias Borchert, ME Miranda, Michel Van Herp, MJ Bonnet, Natasha Howard, NK Jaax, P Formenty, P Formenty, P Francesconi, P Roddy, P Roddy, Paul Roddy, PE Rollin, Pedro Pablo Palma, PH Sureau, R Colebunders, R Ndambi, R Siegert, RC Baron, Robert Colebunders, RT Emond, S Becker, SF Dowell, SP Fisher-Hoch, SR Zaki, TH Roels, U Stroher, Y Kalongi, Zabulon Yoti   +66 more
core   +3 more sources

Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats

Nature Communications, 2017
Bats are natural hosts for Marburg virus (MARV), but the mechanism of bat-to-bat transmission is unclear. Here, Schuhet al. monitor MARV infection in a cohort of 38 bats over nine months, find ‘supershedders’ and show that MARV can horizontally transmit ...
Amy J. Schuh, Brian R. Amman, Megan E. B. Jones, Tara K. Sealy, Luke S. Uebelhoer, Jessica R. Spengler, Brock E. Martin, Jo Ann D. Coleman-McCray, Stuart T. Nichol, Jonathan S. Towner   +9 more
doaj   +1 more source

Mapping the zoonotic niche of Marburg virus disease in Africa. [PDF]

, 2015
BACKGROUND: Marburg virus disease (MVD) describes a viral haemorrhagic fever responsible for a number of outbreaks across eastern and southern Africa. It is a zoonotic disease, with the Egyptian rousette (Rousettus aegyptiacus) identified as a reservoir ...
Brady, Oliver J, Golding, Nick, Hay, Simon I, Huang, Zhi, Kraemer, Moritz UG, Mylne, Adrian, Pigott, David M, Weiss, Daniel J   +7 more
core   +2 more sources

A surrogate BSL2-compliant infection model recapitulating key aspects of human Marburg virus disease

Emerging Microbes and Infections
Marburg virus disease (MVD) is a severe infectious disease caused by the Marburg virus (MARV), posing a significant threat to humans. MARV needs to be operated under strict biosafety Level 4 (BSL-4) laboratory conditions.
Wanying Yang, Wujie Zhou, Bo Liang, Xiaojun Hu, Shen Wang, Zhenshan Wang, Tiecheng Wang, Xianzhu Xia, Na Feng, Yongkun Zhao, Feihu Yan   +10 more
doaj   +1 more source

A rabies virus-vectored vaccine expressing two copies of the Marburg virus glycoprotein gene induced neutralizing antibodies against Marburg virus in humanized mice

Emerging Microbes and Infections, 2023
Marburg virus disease (MVD) is a lethal viral haemorrhagic fever caused by Marburg virus (MARV) with a case fatality rate as high as 88%. There is currently no vaccine or antiviral therapy approved for MVD.
Jinhao Bi, Haojie Wang, Qiuxue Han, Hongyan Pei, Hualei Wang, Hongli Jin, Song Jin, Hang Chi, Songtao Yang, Yongkun Zhao, Feihu Yan, Liangpeng Ge, Xianzhu Xia   +12 more
doaj   +1 more source

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]

, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson, Allison, Almeida, Amman, Amman, Baker, Biesold, Bolger, Carette, Carroll, Carstea, Chandran, Cui, Côté, Daugherty, Deffieu, Delport, Demogines, Demogines, Drexler, Ebihara, Feldmann, Ge, Gire, Grabherr, He, Herbert, Hueffer, Jahrling, Jangra, Jayme, Jones, Kaelber, Kamins, Katzourakis, Krishnan, Kugelman, Kuhn, Kühl, Lee, Leroy, Li, Mali, Maruyama, Meyerson, Miller, Miller, Miller-Butterworth, Murrell, Negredo, Ng, Olival, Park, Parker, Paweska, Peel, Pond, Radoshitzky, Radoshitzky, Raj, Ren, Robertson, Ross, Runz, Ruxton, Sheahan, Swenson, Swenson, Takada, Taylor, Taylor, Taylor, Tong, Towner, Vanier, Volchkov, Wahl-Jensen, Wong, Yang   +78 more
core   +2 more sources

Development of a T7-Independent MARV Minigenome System

Proceedings, 2020
Marburg virus (MARV) is the only known pathogenic filovirus that does not belong to the genus Ebolavirus. It causes a severe hemorrhagic fever that is associated with a high mortality rate (>80%).
Bert Vanmechelen, Joren Stroobants, Kurt Vermeire, Piet Maes   +3 more
doaj   +1 more source