Immunoinformatic and reverse vaccinology-based designing of potent multi-epitope vaccine against Marburgvirus targeting the glycoprotein [PDF]
Heliyon, 2023 Marburg virus (MARV) has been a major concern since its first outbreak in 1967. Although the deadly BSL-4 pathogen has been reported in few individuals with sporadic outbreaks following 1967, its rarity commensurate the degree of disease severity.
Anam Naz
exaly +8 more sources
Marburgvirus Hijacks Nrf2-Dependent Pathway by Targeting Nrf2-Negative Regulator Keap1 [PDF]
Cell Reports, 2014 Marburg virus (MARV) has a high fatality rate in humans, causing hemorrhagic fever characterized by massive viral replication and dysregulated inflammation.
Mathieu Mateo +2 more
exaly +8 more sources
Marburgvirus in Egyptian Fruit Bats, Zambia [PDF]
Emerging Infectious Diseases, 2019 We detected Marburg virus genome in Egyptian fruit bats (Rousettus aegyptiacus) captured in Zambia in September 2018. The virus was closely related phylogenetically to the viruses that previously caused Marburg outbreaks in the Democratic Republic of the
Hirohito Ogawa +2 more
exaly +8 more sources
Experimental Inoculation of Egyptian Rousette Bats (Rousettus aegyptiacus) with Viruses of the Ebolavirus and Marburgvirus Genera [PDF]
Viruses, 2015 The Egyptian rousette bat (Rousettus aegyptiacus) is a natural reservoir for marburgviruses and a consistent source of virus spillover to humans. Cumulative evidence suggests various bat species may also transmit ebolaviruses.
Amy J Schuh, Tara Sealy, Megan E B Jones
exaly +8 more sources
PLoS Pathogens, 2010 Vertebrate genomes contain numerous copies of retroviral sequences, acquired over the course of evolution. Until recently they were thought to be the only type of RNA viruses to be so represented, because integration of a DNA copy of their genome is ...
Vladimir A Belyi +2 more
exaly +7 more sources
Marburgvirus Resurgence in Kitaka Mine Bat Population after Extermination Attempts, Uganda [PDF]
Emerging Infectious Diseases, 2014 To the Editor: Marburg virus (MARV) and Ravn virus (RAVV), collectively called marburgviruses, cause Marburg hemorrhagic fever (MHF) in humans. In July 2007, 4 cases of MHF (1 fatal) occurred in miners at Kitaka Mine in southern Uganda. Later, MHF occurred in 2 tourists who visited Python Cave, ≈50 km from Kitaka Mine.
Brian R Amman +2 more
exaly +7 more sources
Discovery of common marburgvirus protective epitopes in a BALB/c mouse model [PDF]
Virology Journal, 2009 Background Marburg virus (MARV) causes acute hemorrhagic fever that is often lethal, and no licensed vaccines are available for preventing this deadly viral infection.
Olinger Gene G +3 more
doaj +6 more sources
Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies [PDF]
Frontiers in Immunology, 2017 Marburg virus (MARV) is a highly lethal hemorrhagic fever virus that is increasingly re-emerging in Africa, has been imported to both Europe and the US, and is also a Tier 1 bioterror threat.
Andrew Hayhurst
exaly +4 more sources
Preliminary Investigation of Schmalhausen’s Law in a Directly Transmitted Pathogen Outbreak System [PDF]
Viruses, 2023 The past few decades have been marked by drastic modifications to the landscape by anthropogenic processes, leading to increased variability in the environment. For populations that thrive at their distributional boundaries, these changes can affect them
Antoine Filion +2 more
doaj +2 more sources
Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats [PDF]
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
doaj +2 more sources