Pre-symptomatic diagnosis and treatment of filovirus diseases
Frontiers in Microbiology, 2015 Filoviruses are virulent human pathogens which cause severe illness with high case fatality rates and for which there are no available FDA-approved vaccines or therapeutics.
Amy C Shurtleff +4 more
doaj +1 more source
Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]
, 2018 Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G. +7 more
core +1 more source
Niemann-Pick C1 (NPC1)/NPC1-like1 Chimeras Define Sequences Critical for NPC1’s Function as a Filovirus Entry Receptor [PDF]
, 2012 We recently demonstrated that Niemann-Pick C1 (NPC1), a ubiquitous 13-pass cellular membrane protein involved in lysosomal cholesterol transport, is a critical entry receptor for filoviruses.
Chandran, Kartik +7 more
core +2 more sources
Untersuchungen zum intrazellulären Transportmechanismus von Marburgvirus Nukleokapsiden
, 2013 Das Marburgvirus bildet zusammen mit dem Ebolavirus die Familie der Filoviridae. Beide Viren lösen beim Menschen und bei nicht-menschlichen Primaten ein starkes hämorrhagisches Fie-ber mit hoher Sterblichkeitsrate aus. Die Viren besitzen ein einzelsträngiges, nicht-segmentiertes RNA-Genom in negativer Orientierung und
openaire +3 more sources
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study. [PDF]
, 2016 BACKGROUND: The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates. On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of the monovalent, recombinant, chimpanzee adenovirus type-3 vector-based ...
Audran, R. +24 more
core +1 more source
Filoviruses in Bats: Current Knowledge and Future Directions
Viruses, 2014 Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and
Kevin J. Olival, David T. S. Hayman
doaj +1 more source
Charakterisierung der Rolle des endosomalen Recycling-Systems für den intrazellulären Transport des Marburg Virus Glykoproteins [PDF]
, 2019 Das Marburg Virus (MARV), das zur Familie der Filoviridae gezählt wird, ist ein Erreger schwerer Fieber mit Letalitätsraten von bis zu 90 %. Das Glykoprotein GP stellt das einzige Oberflächenprotein des MARV dar und daher ist sein korrekter Transport zu ...
Halwe, Sandro
core +1 more source
Taxonomy of the order Mononegavirales : update 2016 [PDF]
, 2016 In 2016, the order Mononegavirales was emended through the addition of two new families (Mymonaviridae and Sunviridae), the elevation of the paramyxoviral subfamily Pneumovirinae to family status (Pneumoviridae), the addition of five free-floating genera
Afonso, Claudio L. +82 more
core +1 more source
Serological Detection of Ebola Virus Exposures in Native Non-human Primates of Southern Nigeria
Journal of Epidemiology and Global Health, 2018 Ebola viruses (family: Filoviridae) are the cause of Ebola virus disease (EVD), a highly fatal illness characterised by haemorrhagic fever syndrome in both humans and non-human primates (NHPs).
B.N. Ogunro +5 more
doaj +1 more source
The nexus between forest fragmentation in Africa and Ebola virus disease outbreaks [PDF]
, 2017 Tropical forests are undergoing land use change in many regions of the world, including the African continent. Human populations living close to forest margins fragmented and disturbed by deforestation may be particularly exposed to zoonotic infections ...
D'Odorico, Paolo +3 more
core +2 more sources