Results 71 to 80 of about 2,647 (192)

Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg Virus

Advances in Bioinformatics, Volume 2015, Issue 1, 2015., 2015
Heterogeneities in nucleotide content distribution along the length of Zaire ebolavirus and Marburg virus genomes have been analyzed. Results showed that there is asymmetric mutational A‐pressure in the majority of Zaire ebolavirus genes; there is mutational AC‐pressure in the coding region of the matrix protein VP40, probably, caused by its high ...
Vladislav Victorovich Khrustalev, Eugene Victorovich Barkovsky, Tatyana Aleksandrovna Khrustaleva, Huixiao Hong   +3 more
wiley   +1 more source

On the Mathematical Analysis of Ebola Hemorrhagic Fever: Deathly Infection Disease in West African Countries

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
For a given West African country, we constructed a model describing the spread of the deathly disease called Ebola hemorrhagic fever. The model was first constructed using the classical derivative and then converted to the generalized version using the beta‐derivative.
Abdon Atangana, Emile Franc Doungmo Goufo, Suares Clovis Oukouomi Noutchie   +2 more
wiley   +1 more source

Natural History of Marburg Virus Infection to Support Medical Countermeasure Development

Viruses, 2022
The Biomedical Advanced Research and Development Authority, part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, recognizes that the evaluation of medical countermeasures under the ...
Jason E. Comer, Trevor Brasel, Shane Massey, David W. Beasley, Chris M. Cirimotich, Daniel C. Sanford, Ying-Liang Chou, Nancy A. Niemuth, Joseph Novak, Carol L. Sabourin, Michael Merchlinsky, James P. Long, Eric J. Stavale, Daniel N. Wolfe   +13 more
doaj   +1 more source

Essentials of Filoviral Load Quantification [PDF]

, 2016
Quantitative measurement of viral load is an important parameter in the management of filovirus disease outbreaks because viral load correlates with severity of disease, survival, and infectivity.
Ariën, KK, Bausch, DG, Cnops, L, Colebunders, R, Formenty, P, Griffiths, A, Hewlett, A, Hill, CE, Honko, AN, Jahrling, PB, Johnson, JC, Kobinger, G, Kraft, CS, Kuhn, JH, Norwood, DA, Palacios, GF, Sabeti, P, Sprecher, A, van Griensven, J   +18 more
core   +1 more source

Seroreactivity against Marburg or related filoviruses in West and Central Africa

Emerging Microbes and Infections, 2020
A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries.
Imke Steffen, Kai Lu, Nicole A. Hoff, Prime Mulembakani, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A. Brennan, John Hackett, William M. Switzer, Sentob Saragosti, Guy O. Mbensa, Syria Laperche, Anne W. Rimoin, Graham Simmons   +14 more
doaj   +1 more source

Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

BMC Infectious Diseases, 2018
Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba, Misaki Wayengera   +9 more
doaj   +1 more source

A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making. [PDF]

, 2015
The unprecedented scale of the Ebola outbreak in West Africa has, as of 29 April 2015, resulted in more than 10,884 deaths among 26,277 cases. Prior to the ongoing outbreak, Ebola virus disease (EVD) caused relatively small outbreaks (maximum outbreak ...
Bento, AI, Donnelly, CA, Ferguson, NM, Mills, HL, Van Kerkhove, MD   +4 more
core   +1 more source

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

Investigating the zoonotic origin of the West African Ebola epidemic [PDF]

, 2014
The severe Ebola virus disease epidemic occurring in West Africa stems from a single zoonotic transmission event to a 2‐year‐old boy in Meliandou, Guinea.
Aleksandar Radonić, Almudena Marí Saéz, Andreas Nitsche, Andreas Sachse, Ariane Düx, Boiro I, Chantal Akoua‐Koffi, Christophe Boesch, Dudas G, Emmanuel Couacy‐Hymann, Fabian H Leendertz, Fee Zimmermann, Hjalmar S Kühl, Jakob Fahr, Jan F Gogarten, Kathrin Nowak, Kevin Merkel, Lars Schaade, Lili Villányi, Matthias Borchert, Moussa Kaba, Natalie Weber, Piotr W Dabrowski, Sabrina Weiss, Sebastien Regnaut, Siv Aina J Leendertz, Stefan Petterson, Stephan Becker, Sébastien Calvignac‐Spencer, Ulla Thiesen, Verena Krähling, Vincent Lapeyre, World Health Organization/International Study Team   +32 more
core   +10 more sources

Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]

Journal of Virology, 2011
ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L, Lofts, Jay B, Wells, Sina, Bavari, Kelly L, Warfield   +3 more
openaire   +2 more sources