Results 61 to 70 of about 1,487 (150)

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

Evolutionary maintenance of filovirus-like genes in bat genomes

BMC Evolutionary Biology, 2011
Background Little is known of the biological significance and evolutionary maintenance of integrated non-retroviral RNA virus genes in eukaryotic host genomes.
Taylor Derek J, Dittmar Katharina, Ballinger Matthew J, Bruenn Jeremy A   +3 more
doaj   +1 more source

Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]

Journal of Virology, 2018
ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV ...
Demetrius, Matassov, Chad E, Mire, Theresa, Latham, Joan B, Geisbert, Rong, Xu, Ayuko, Ota-Setlik, Krystle N, Agans, Dean J, Kobs, Morgan Q S, Wendling, Amanda, Burnaugh, Thomas L, Rudge, Carol L, Sabourin, Michael A, Egan, David K, Clarke, Thomas W, Geisbert, John H, Eldridge   +15 more
openaire   +2 more sources

Filoviral Immune Evasion Mechanisms

Viruses, 2011
The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a
Christopher F. Basler, Gaya K. Amarasinghe, Craig S. Brown, Reed S. Shabman, Parameshwaran Ramanan, Daisy W. Leung   +5 more
doaj   +1 more source

Mechanisms of immunity in post-exposure vaccination against Ebola virus infection. [PDF]

PLoS ONE, 2015
Ebolaviruses can cause severe hemorrhagic fever that is characterized by rapid viral replication, coagulopathy, inflammation, and high lethality rates.
Steven B Bradfute, Scott M Anthony, Kelly S Stuthman, Natarajan Ayithan, Prafullakumar Tailor, Carl I Shaia, Mike Bray, Keiko Ozato, Sina Bavari   +8 more
doaj   +1 more source

Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]

Journal of Virology, 2011
ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L, Lofts, Jay B, Wells, Sina, Bavari, Kelly L, Warfield   +3 more
openaire   +2 more sources

Suspected Ebolavirus Reservoir Species in Anthropogenic Landscapes

The Bulletin of the Ecological Society of America, Volume 106, Issue 2, April 2025.
Matthew LeBreton, Robert L. Cohen
wiley   +1 more source

Pre-symptomatic diagnosis and treatment of filovirus diseases

Frontiers in Microbiology, 2015
Filoviruses are virulent human pathogens which cause severe illness with high case fatality rates and for which there are no available FDA-approved vaccines or therapeutics.
Amy C Shurtleff, Chris A Whitehouse, Lisa H Cazares, Michael D Ward, Sina eBavari   +4 more
doaj   +1 more source

Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection. [PDF]

Vaccine
Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are no vaccines for two other highly pathogenic members of the Filoviridae, Sudan ebolavirus (SUDV) and Marburg marburgvirus (MARV).
To A, Wong TAS, Ball AH, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Elyard HA, Borisevich V, Agans KN, Deer DJ, Woolsey C, Cross RW, Geisbert TW, Donini O, Lehrer AT.   +16 more
europepmc   +3 more sources

Filoviruses in Bats: Current Knowledge and Future Directions

Viruses, 2014
Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and
Kevin J. Olival, David T. S. Hayman
doaj   +1 more source