Recent advances in marburgvirus research [version 1; peer review: 3 approved] [PDF]
F1000Research, 2019 Marburgviruses are closely related to ebolaviruses and cause a devastating disease in humans. In 2012, we published a comprehensive review of the first 45 years of research on marburgviruses and the disease they cause, ranging from molecular biology to ...
Judith Olejnik +2 more
doaj +6 more sources
Development of a model for marburgvirus based on severe-combined immunodeficiency mice [PDF]
Virology Journal, 2007 The filoviruses, Ebola (EBOV) and Marburg (MARV), cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and, to date, there are no reports of a mouse-adapted MARV model. Previously, a uniformly lethal EBOV-
Kalina Warren V +7 more
doaj +6 more sources
Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola [PDF]
Journal of Virology, 2006 ABSTRACT In March 2005, the Centers for Disease Control and Prevention (CDC) investigated a large hemorrhagic fever (HF) outbreak in Uige Province in northern Angola, West Africa. In total, 15 initial specimens were sent to CDC, Atlanta, Ga., for testing for viruses associated with viral HFs known to be present in West Africa, including ...
Jonathan S Towner +2 more
exaly +5 more sources
No evidence for the involvement of the argasid tick Ornithodoros faini in the enzootic maintenance of marburgvirus within Egyptian rousette bats Rousettus aegyptiacus [PDF]
Parasites and Vectors, 2016 (Uploaded by Plazi for the Bat Literature Project) The cave-dwelling Egyptian rousette bat (ERB; Rousettus aegyptiacus) was recently identified as a natural reservoir host of marburgviruses. However, the mechanisms of transmission for the enzootic maintenance of marburgviruses within ERBs are unclear.
Amy J Schuh +2 more
exaly +7 more sources
Conserved Receptor-binding Domains of Lake Victoria Marburgvirus and Zaire Ebolavirus Bind a Common Receptor [PDF]
Journal of Biological Chemistry, 2006 The GP(1,2) envelope glycoproteins (GP) of filoviruses (marburg- and ebolaviruses) mediate cell-surface attachment, membrane fusion, and entry into permissive cells. Here we show that a 151-amino acid fragment of the Lake Victoria marburgvirus GP1 subunit bound filovirus-permissive cell lines more efficiently than full-length GP1.
Jens H Kuhn +2 more
exaly +5 more sources
Identification of Filovirus Entry Inhibitors from Marine Fungus-Derived Indole Alkaloids [PDF]
Marine DrugsFiloviruses, mainly consisting of the two genera of Ebolavirus and Marburgvirus, are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates.
Leah Liu Wang +6 more
doaj +2 more sources
The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding [PDF]
Cell Host and Microbe, 2018 Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%-90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in non-human primates when delivered several days after inoculation of a lethal marburgvirus ...
Liam B King, Andrew I Flyak, Kai Huang
exaly +6 more sources
Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among Marburgvirus and Dianlovirus [PDF]
Viruses, 2019 We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the E. coli periplasm.
Laura J. Sherwood, Andrew Hayhurst
doaj +2 more sources
Prevalence of human filovirus infections in sub-Saharan Africa: A systematic review and meta-analysis protocol [PDF]
Systematic ReviewsBackground Recent outbreaks of Ebola virus disease (EVD) and Marburg virus disease (MVD) in sub-Saharan Africa illustrate the need to better understand animal reservoirs, burden of disease, and human transmission of filoviruses.
Christopher S. Semancik +10 more
doaj +2 more sources
Budding of Marburgvirus is associated with filopodia [PDF]
Cellular Microbiology, 2006 Viruses exploit the cytoskeleton of host cells to transport their components and spread to neighbouring cells. Here we show that the actin cytoskeleton is involved in the release of Marburgvirus (MARV) particles. We found that peripherally located nucleocapsids and envelope precursors of MARV are located either at the tip or at the side of filopodial ...
Larissa Kolesnikova +3 more
openalex +3 more sources