Results 21 to 30 of about 2,702 (198)
Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]
Journal of Virology, 2011 ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R. Radoshitzky +18 more
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Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]
Molecular Aspects of Medicine, 2007 Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
Paolo Ascenzi +7 more
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Japanese Journal of Infectious Diseases, 2006 There have recently been large outbreaks of Marburg hemorrhagic fever (MHF) caused by Marburgvirus (MARV) in the Democratic Republic of Congo and Angola. The development of reliable diagnostic systems for MHF is urgently needed. An antigen-capture enzyme-linked immunosorbent assay (Ag-capture ELISA) using either of the two monoclonal antibodies (2A7 ...
Masayuki Saijo +7 more
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SSRN Electronic Journal, 2022 Marburgvirus (MARV), a member of the Filovirus family, causes severe hemorrhagic fever in humans. Currently, there are no approved vaccines or post exposure treatment methods available against MARV. With the aim of identifying vaccine candidates against MARV, we employ different sequence-based computational methods to predict the MHC-I and MHC-II T ...
Prabin Baral +7 more
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Marburgvirus: A Global Virus, not just an African problem
Journal of Advances in Internal Medicine, 2023 The Marburg virus (MBV) phylogenetically belongs to the filovirus family and its clinical picture, spread and virulence resemble the Ebola virus very closely. The marked virulence of MBV is of great concern for not only the African region, but the globe in its entirety as a recent outbreak of the virus from a lab handling African green monkeys has ...
Jared Robinson +2 more
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Untersuchungen zum intrazellulären Transportmechanismus von Marburgvirus Nukleokapsiden
, 2013 Das Marburgvirus bildet zusammen mit dem Ebolavirus die Familie der Filoviridae. Beide Viren lösen beim Menschen und bei nicht-menschlichen Primaten ein starkes hämorrhagisches Fie-ber mit hoher Sterblichkeitsrate aus. Die Viren besitzen ein einzelsträngiges, nicht-segmentiertes RNA-Genom in negativer Orientierung und
Gordian Schudt
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The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding [PDF]
Cell Host & Microbe, 2018 Since their first identification 50 years ago, marburgviruses have emerged several times, with 83%-90% lethality in the largest outbreaks. Although no vaccines or therapeutics are available for human use, the human antibody MR191 provides complete protection in non-human primates when delivered several days after inoculation of a lethal marburgvirus ...
Liam King +13 more
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Reemergence of Marburgvirus disease: Update on current control and prevention measures and review of the literature [PDF]
Reviews in Medical Virology, 2023 AbstractIn 1967, the very first case of the Marburgvirus disease (MVD) was detected in Germany and Serbia sequentially. Since then, MVD has been considered one of the most serious and deadly infectious diseases in the world with a case‐fatality rate between 23% and 90% and a substantial number of recorded deaths.
Randa Elsheikh +7 more
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Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies [PDF]
Frontiers in Immunology, 2017 Marburg virus (MARV) is a highly lethal hemorrhagic fever virus that is increasingly re-emerging in Africa, has been imported to both Europe and the US, and is also a Tier 1 bioterror threat.
John Anthony Garza +5 more
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Vaccinomics strategy for developing a unique multi-epitope monovalent vaccine against Marburg marburgvirus [PDF]
Infection, Genetics and Evolution, 2018 Marburg virus causes severe hemorrhagic fever in both humans and non-human primates with high degree of infectivity and lethality. To date no approved treatment is available for Marburg virus infection. A study was employed to design a novel chimeric vaccine against Marburg virus by adopting reverse vaccinology approach.
Mahmudul Hasan +7 more
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