Results 21 to 30 of about 2,838 (206)

Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription [PDF]

open access: greenJournal of Virology, 2005
ABSTRACT The nucleocapsid protein VP35 of Marburgvirus, a filovirus, acts as the cofactor of the viral polymerase and plays an essential role in transcription and replication of the viral RNA. VP35 forms complexes with the genome encapsidating protein NP and with the RNA-dependent RNA polymerase L.
Peggy Möller   +3 more
semanticscholar   +6 more sources

Immunoinformatic screening of Marburgvirus epitopes and computational investigations of epitope-allele complexes

open access: bronzeSSRN Electronic Journal, 2022
Marburgvirus (MARV), a member of the Filovirus family, causes severe hemorrhagic fever in humans. Currently, there are no approved vaccines or post exposure treatment methods available against MARV.
Prabin Baral   +7 more
semanticscholar   +5 more sources

Cross-reactive macaque antibodies targeting marburgvirus glycoprotein induced by multivalent immunization [PDF]

open access: greenbioRxiv, 2023
AbstractWe utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus   +7 more
semanticscholar   +3 more sources

Marburgvirus: A Global Virus, not just an African problem

open access: hybridJournal of Advances in Internal Medicine, 2023
The Marburg virus (MBV) phylogenetically belongs to the filovirus family and its clinical picture, spread and virulence resemble the Ebola virus very closely.
Jared Robinson   +2 more
semanticscholar   +4 more sources

Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]

open access: greenJournal of Virology, 2011
ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R. Radoshitzky   +18 more
semanticscholar   +6 more sources

Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae [PDF]

open access: bronzeArchives of Virology, 2023
The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group continues to prospectively refine the established nomenclature for taxa included in family Filoviridae in an effort to decrease confusion of genus, species, and virus names and to adhere to amended stipulations of the International Code of Virus Classification and ...
Nadine Biedenkopf   +14 more
semanticscholar   +4 more sources

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non-human primates

open access: goldPLoS ONE, 2018
The search for a universal filovirus vaccine that provides protection against multiple filovirus species has been prompted by sporadic but highly lethal outbreaks of Ebolavirus and Marburgvirus infections.
Roland Zahn   +2 more
exaly   +4 more sources

Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]

open access: bronzeJournal of Virology, 2017
ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV) protected nonhuman primates ...
Demetrius Matassov   +15 more
semanticscholar   +5 more sources

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses [PDF]

open access: yesViruses, 2017
The mononegaviral family Filoviridae has eight members assigned to three genera and seven species. Until now, genus and species demarcation were based on arbitrarily chosen filovirus genome sequence divergence values (≈50% for genera, ≈30% for species ...
Yīmíng Bào   +22 more
doaj   +3 more sources

Preliminary Investigation of Schmalhausen’s Law in a Directly Transmitted Pathogen Outbreak System [PDF]

open access: yesViruses, 2023
The past few decades have been marked by drastic modifications to the landscape by anthropogenic processes, leading to increased variability in the environment. For populations that thrive at their distributional boundaries, these changes can affect them
Antoine Filion   +2 more
doaj   +2 more sources

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