Recent outbreak of Marburg virus disease: Could it be a threat for global public health?
Health Science Reports, 2023 Health Science Reports, Volume 6, Issue 1, January 2023.
Md. Sohan +3 more
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Structural and biochemical characterization of marburgvirus VP35 and its role in immune evasion
, 2012 Filoviruses are among the most deadly pathogens that cause acute disease in humans. Ebolavirus (EBOV) and marburgvirus (MARV) are the two members of this family, which have been documented to cause infrequent but severe outbreaks of hemorrhagic fever in humans. The severe pathogenesis and high lethality associated with filoviral infections, is in part,
Parameshwaran Ramanan
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Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]
Journal of Virology, 2011 ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L. Lofts +3 more
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T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus [PDF]
Proceedings of the National Academy of Sciences, 2011 The glycoproteins (GP) of enveloped viruses facilitate entry into the host cell by interacting with specific cellular receptors. Despite extensive study, a cellular receptor for the deadly filoviruses Ebolavirus and Marburgvirus has yet to be identified and characterized. Here, we show that T-
Andrew S. Kondratowicz +15 more
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Viruses, 2021 Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi +3 more
doaj +1 more source
Cross-reactive macaque antibodies targeting marburgvirus glycoprotein induced by multivalent immunization [PDF]
, 2023 AbstractWe utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus +7 more
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Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial [PDF]
Journal of Infectious Diseases, 2014 Ebolavirus and Marburgvirus cause severe hemorrhagic fever with high mortality and are potential bioterrorism agents. There are no available vaccines or therapeutic agents. Previous clinical trials evaluated transmembrane-deleted and point-mutation Ebolavirus glycoproteins (GPs) in candidate vaccines. Constructs evaluated in this trial encode wild-type
Uzma Sarwar +36 more
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Marburgvirus: A Global Virus, not just an African problem
Journal of Advances in Internal Medicine, 2023 The Marburg virus (MBV) phylogenetically belongs to the filovirus family and its clinical picture, spread and virulence resemble the Ebola virus very closely. The marked virulence of MBV is of great concern for not only the African region, but the globe in its entirety as a recent outbreak of the virus from a lab handling African green monkeys has ...
Jared Robinson +2 more
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Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia
Viruses, 2021 Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula +9 more
doaj +1 more source
Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]
Journal of Virology, 2017 ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV) protected nonhuman primates ...
Demetrius Matassov +15 more
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