Results 31 to 40 of about 2,475 (189)

The recent outbreaks of Marburg virus disease in African countries are indicating potential threat to the global public health: Future prediction from historical data

Health Science Reports, Volume 6, Issue 7, July 2023., 2023
Abstract Marburg virus disease (MVD) caused by the Marburg virus has a high mortality rate. Rousettus aegyptiacus fruit bats act as the natural reservoir host of the virus. But it can also potentially be transmitted from person to person through direct contact with body secretions.
Iftekhar Ahmed, Lubaba Salsabil, Md. Jamal Hossain, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam   +5 more
wiley   +1 more source

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements [PDF]

, 2022
Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses ...
Honda, Tomoyuki, Ogawa, Hirohito
core   +1 more source

Investigating Infectious Organisms of Public Health Concern Associated with Wild Meat

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
The wild meat trade poses a significant threat to public health as it facilitates the spillover of zoonotic pathogens through high‐risk activities such as the hunting, butchering, trade, and consumption of wild animals. Despite the health risks and association with marking epidemics including SARS, Ebola, and COVID‐19, the global wild meat trade ...
Georgia Kate Moloney, Philippe Gaubert, Sophie Gryseels, Erik Verheyen, Anne-Lise Chaber, Karima Al Salihi   +5 more
wiley   +1 more source

Development and Structural Analysis of Antibody Therapeutics for Filoviruses

Pathogens, 2022
The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj   +1 more source

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity

Journal of Extracellular Vesicles, Volume 11, Issue 3, March 2022., 2022
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immune induction remains unclear.
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock   +9 more
wiley   +1 more source

Plasmodium berghei‐Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival

Cellular Microbiology, Volume 2022, Issue 1, 2022., 2022
The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the host cell is crucial for successful completion of liver stage development.
Annina Bindschedler, Jacqueline Schmuckli-Maurer, Rahel Wacker, Nicolas Kramer, Ruth Rehmann, Reto Caldelari, Volker T. Heussler, Roberto Botelho   +7 more
wiley   +1 more source

Filovirus Entry: A Novelty in the Viral Fusion World

Viruses, 2012
Ebolavirus (EBOV) and Marburgvirus (MARV) that compose the filovirus family of negative strand RNA viruses infect a broad range of mammalian cells.
Wendy Maury, Catherine L. Hunt, Nicholas J. Lennemann   +2 more
doaj   +1 more source

Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]

, 2008
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher, Anon., Baize, Basler, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Bausch, Benjamin Jeffs, Bernard, Borchert, Bosio, Bosio, Boumandouki, Bray, Bray, Bray, Bray, Brummel-Ziedins, Bukreyev, Bwaka, CDC and WHO, Colebunders, Daddario-DiCaprio, Daniel G. Bausch, Dowell, Egbring, Emond, Enterlein, Feldmann, Formenty, Fourrier, Gear, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Geisbert, Gibbs, Gupta, Hensley, Hensley, Hensley, Hewlett, Hewlett, Hoenen, Hotchkiss, Huggins, Jahrling, Jahrling, Jahrling, Jeffs, Johnson, Jones, Jones, Khan, Ksiazek, Kudoyarova-Zubavichene, Larkin, Leroy, Leroy, Mahanty, Mahanty, Martin, Martini, Martini, Monath, Mupapa, Mupapa, Nikiforov, Oswald, Parrino, Pattyn, Paul Boumandouki, Peters, Peterson, Peterson, Pourrut, Reid, Rivers, Roberts, Rollin, Sanchez, Schnittler, Schuler, Smith, Spurgers, Stille, Sullivan, Sullivan, Swanepoel, Takada, Todorovitch, Towner, Warfield, Warfield, Warfield, Wilson, Zaki   +105 more
core   +2 more sources

Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies

Viruses, 2012
The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Gene G. Olinger, Ana Kuehne, Jennifer L. Audet, Kendra J. Alfson, Anthony Griffiths, Holly A. Bloomfield, Elizabeth E. Zumbrun, Ashley E. Keeney, Julia E. Biggins, Amy C. Shurtleff, Sina Bavari   +10 more
doaj   +1 more source