Cross-reactive macaque antibodies targeting marburgvirus glycoprotein induced by multivalent immunization [PDF]
, 2023 AbstractWe utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus +7 more
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Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription [PDF]
Journal of Virology, 2005 ABSTRACT The nucleocapsid protein VP35 of Marburgvirus, a filovirus, acts as the cofactor of the viral polymerase and plays an essential role in transcription and replication of the viral RNA. VP35 forms complexes with the genome encapsidating protein NP and with the RNA-dependent RNA polymerase L.
Peggy Möller +3 more
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Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola [PDF]
Journal of Virology, 2006 ABSTRACT In March 2005, the Centers for Disease Control and Prevention (CDC) investigated a large hemorrhagic fever (HF) outbreak in Uige Province in northern Angola, West Africa. In total, 15 initial specimens were sent to CDC, Atlanta, Ga., for testing for viruses associated with viral HFs known to be present in West Africa ...
Jonathan S. Towner +14 more
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Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection. [PDF]
Vaccine, 2023 Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are no vaccines for two other highly pathogenic members of the Filoviridae, Sudan ebolavirus (SUDV) and Marburg marburgvirus (MARV).
To A +16 more
europepmc +5 more sources
Periplasmic Nanobody-APEX2 Fusions Enable Facile Visualization of Ebola, Marburg, and Mĕnglà virus Nucleoproteins, Alluding to Similar Antigenic Landscapes among Marburgvirus and Dianlovirus [PDF]
Viruses, 2019 We explore evolved soybean ascorbate peroxidase (APEX2) as a reporter when fused to the C-termini of llama nanobodies (single-domain antibodies, sdAb; variable domains of heavy chain-only antibodies, VHH) targeted to the E. coli periplasm.
Laura J. Sherwood, Andrew Hayhurst
doaj +2 more sources
Virology, 2016 Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling.
Jonathan C. Guito +3 more
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Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]
Journal of Virology, 2017 ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV ...
Demetrius Matassov +15 more
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Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus Variant Selection Process [PDF]
Journal of Virology, 2011 ABSTRACT Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naïve mice to propagate a lethal infection.
Loreen L. Lofts +3 more
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Funktionelle Charakterisierung der cytoplasmatischen Domäne des Marburgvirus Oberflächenproteins GP
, 2010 The family of Filoviridae comprises Marburg virus (MARV) and Ebola virus, which are the causative agents of fulminant haemorrhagic fevers in humans and non-human primates. Infection of target cells is mediated by binding of viral particles to their cellular receptor, followed by endocytosis, fusion of viral and endosomal membranes, release of the ...
Eva-Maria Mittler
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