Results 31 to 40 of about 1,514 (157)
Japanese Journal of Infectious Diseases, 2006 There have recently been large outbreaks of Marburg hemorrhagic fever (MHF) caused by Marburgvirus (MARV) in the Democratic Republic of Congo and Angola. The development of reliable diagnostic systems for MHF is urgently needed. An antigen-capture enzyme-linked immunosorbent assay (Ag-capture ELISA) using either of the two monoclonal antibodies (2A7 ...
Masayuki Saijo +7 more
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Ebolavirus Δ-Peptide Immunoadhesins Inhibit Marburgvirus and Ebolavirus Cell Entry [PDF]
Journal of Virology, 2011 ABSTRACT With the exception of Reston and Lloviu viruses, filoviruses (marburgviruses, ebolaviruses, and “cuevaviruses”) cause severe viral hemorrhagic fevers in humans. Filoviruses use a class I fusion protein, GP 1,2 , to bind to an unknown, but shared, cell surface receptor to initiate virus-cell fusion.
Sheli R. Radoshitzky +18 more
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Marburg Virus Disease: A Narrative Review. [PDF]
Health Sci RepABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Letafati A +4 more
europepmc +2 more sources
Ebolavirus and Marburgvirus: Insight the Filoviridae family [PDF]
Molecular Aspects of Medicine, 2007 Ebolavirus and Marburgvirus (belonging to the Filoviridae family) emerged four decades ago and cause epidemics of haemorrhagic fever with high case-fatality rates. The genome of filoviruses encodes seven proteins. No significant homology is observed between filovirus proteins and any known macromolecule.
Paolo Ascenzi +7 more
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Cross-reactive macaque antibodies targeting marburgvirus glycoprotein induced by multivalent immunization [PDF]
, 2023 AbstractWe utilized B cells from a Rhesus macaque immunized with a multivalent prime-boost regimen of filovirus antigens to isolate a novel panel of marburgvirus glycoprotein (GP)-specific monoclonal antibodies (mAbs). A heterologous marburgvirus GP probe was used to sort for B cells with cross-marburgvirus reactive breadth.
Benjamin M. Janus +7 more
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Marburgvirus: A Global Virus, not just an African problem
Journal of Advances in Internal Medicine, 2023 The Marburg virus (MBV) phylogenetically belongs to the filovirus family and its clinical picture, spread and virulence resemble the Ebola virus very closely. The marked virulence of MBV is of great concern for not only the African region, but the globe in its entirety as a recent outbreak of the virus from a lab handling African green monkeys has ...
Jared Robinson +2 more
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Reemergence of Marburgvirus disease: Update on current control and prevention measures and review of the literature [PDF]
Reviews in Medical Virology, 2023 AbstractIn 1967, the very first case of the Marburgvirus disease (MVD) was detected in Germany and Serbia sequentially. Since then, MVD has been considered one of the most serious and deadly infectious diseases in the world with a case‐fatality rate between 23% and 90% and a substantial number of recorded deaths.
Randa Elsheikh +7 more
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Vaccinomics strategy for developing a unique multi-epitope monovalent vaccine against Marburg marburgvirus [PDF]
Infection, Genetics and Evolution, 2018 Marburg virus causes severe hemorrhagic fever in both humans and non-human primates with high degree of infectivity and lethality. To date no approved treatment is available for Marburg virus infection. A study was employed to design a novel chimeric vaccine against Marburg virus by adopting reverse vaccinology approach.
Mahmudul Hasan +7 more
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Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using <i>Drosophila</i> S2 Cells. [PDF]
Eng Life SciABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Göbel S +7 more
europepmc +2 more sources
Viruses, 2021 Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the ...
Manabu Igarashi +3 more
doaj +1 more source