Results 41 to 50 of about 2,684 (201)

Novel activities by ebolavirus and marburgvirus interferon antagonists revealed using a standardized in vitro reporter system

Virology, 2016
Filoviruses are highly lethal in humans and nonhuman primates, likely due to potent antagonism of host interferon (IFN) responses early in infection. Filoviral protein VP35 is implicated as the major IFN induction antagonist, while Ebola virus (EBOV) VP24 or Marburg virus (MARV) VP40 are known to block downstream IFN signaling.
Jonathan C. Guito, César G. Albariño, Ayan K. Chakrabarti, Jonathan S. Towner   +3 more
openalex   +3 more sources

The recent outbreaks of Marburg virus disease in African countries are indicating potential threat to the global public health: Future prediction from historical data

Health Science Reports, Volume 6, Issue 7, July 2023., 2023
Abstract Marburg virus disease (MVD) caused by the Marburg virus has a high mortality rate. Rousettus aegyptiacus fruit bats act as the natural reservoir host of the virus. But it can also potentially be transmitted from person to person through direct contact with body secretions.
Iftekhar Ahmed, Lubaba Salsabil, Md. Jamal Hossain, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan, Md. Rabiul Islam   +5 more
wiley   +1 more source

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Viruses, 2021
Ebolaviruses and marburgviruses are filoviruses that are known to cause severe hemorrhagic fever in humans and nonhuman primates (NHPs). While some bat species are suspected to be natural reservoirs of these filoviruses, wild NHPs often act as ...
Katendi Changula, Edgar Simulundu, Boniface Pongombo Lombe, Eri Nakayama, Hiroko Miyamoto, Yuji Takahashi, Hirofumi Sawa, Chuma Simukonda, Bernard M. Hang’ombe, Ayato Takada   +9 more
doaj   +1 more source

Investigating Infectious Organisms of Public Health Concern Associated with Wild Meat

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
The wild meat trade poses a significant threat to public health as it facilitates the spillover of zoonotic pathogens through high‐risk activities such as the hunting, butchering, trade, and consumption of wild animals. Despite the health risks and association with marking epidemics including SARS, Ebola, and COVID‐19, the global wild meat trade ...
Georgia Kate Moloney, Philippe Gaubert, Sophie Gryseels, Erik Verheyen, Anne-Lise Chaber, Karima Al Salihi   +5 more
wiley   +1 more source

Single-Dose Trivalent VesiculoVax Vaccine Protects Macaques from Lethal Ebolavirus and Marburgvirus Challenge [PDF]

Journal of Virology, 2017
ABSTRACT Previous studies demonstrated that a single intramuscular (i.m.) dose of an attenuated recombinant vesicular stomatitis virus (rVSV) vector (VesiculoVax vector platform; rVSV-N4CT1) expressing the glycoprotein (GP) from the Mayinga strain of Zaire ebolavirus (EBOV ...
Demetrius Matassov, Chad E. Mire, Theresa Latham, Joan B. Geisbert, Rong Xu, Ayuko Ota‐Setlik, Krystle N. Agans, Dean J. Kobs, Morgan Q. S. Wendling, Amanda Burnaugh, Thomas L. Rudge, Carol L. Sabourin, Michael A. Egan, David K. Clarke, Thomas W. Geisbert, John H. Eldridge   +15 more
openalex   +3 more sources

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity

Journal of Extracellular Vesicles, Volume 11, Issue 3, March 2022., 2022
Abstract A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs). Whether an antigen in one or more of these forms is superior in immune induction remains unclear.
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock   +9 more
wiley   +1 more source

Plasmodium berghei‐Mediated NRF2 Activation in Infected Hepatocytes Enhances Parasite Survival

Cellular Microbiology, Volume 2022, Issue 1, 2022., 2022
The protozoan parasite Plasmodium, causative agent of malaria, initially invades and develops in hepatocytes where it resides in a parasitophorous vacuole (PV). A single invaded parasite develops into thousands of daughter parasites. Survival of the host cell is crucial for successful completion of liver stage development.
Annina Bindschedler, Jacqueline Schmuckli-Maurer, Rahel Wacker, Nicolas Kramer, Ruth Rehmann, Reto Caldelari, Volker T. Heussler, Roberto Botelho   +7 more
wiley   +1 more source

Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in Angola [PDF]

Journal of Virology, 2006
ABSTRACT In March 2005, the Centers for Disease Control and Prevention (CDC) investigated a large hemorrhagic fever (HF) outbreak in Uige Province in northern Angola, West Africa. In total, 15 initial specimens were sent to CDC, Atlanta, Ga., for testing for viruses associated with viral HFs known to be present in West Africa ...
Jonathan S. Towner, Marina L. Khristova, Tara K. Sealy, Martin J. Vincent, Bobbie R. Erickson, Darcy A. Bawiec, Amy L. Hartman, James A. Comer, Sherif R. Zaki, Ute Ströher, Filomena Gomes da Silva, Fernando del Castillo, Pierre E. Rollin, Thomas G. Ksiazek, Stuart T. Nichol   +14 more
openalex   +3 more sources

Homo-Oligomerization of Marburgvirus VP35 Is Essential for Its Function in Replication and Transcription [PDF]

Journal of Virology, 2005
ABSTRACT The nucleocapsid protein VP35 of Marburgvirus, a filovirus, acts as the cofactor of the viral polymerase and plays an essential role in transcription and replication of the viral RNA. VP35 forms complexes with the genome encapsidating protein NP and with the RNA-dependent RNA polymerase L.
Peggy Möller, Nonia Pariente, Hans‐Dieter Klenk, Stephan Becker   +3 more
openalex   +3 more sources

Phosphorylation of Marburgvirus NP and its influence on the viral life cycle

, 2016
Das Marburgvirus (MARV) bildet zusammen mit Ebolavirus (EBOV) und Lloviuvirus (LLOV) die Familie der Filoviridae und besitzt ein einzelsträngiges RNA-Genom negativer Orientierung. Filoviren werden als BSL-4-Pathogene klassifiziert, da sie schwere hämorrhagische Fieber bei Menschen und Affen verursachen. Das Nukleoprotein
Anne Kelterbaum
openalex   +2 more sources