Results 41 to 50 of about 2,475 (189)

Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis

Viruses, 2018
Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a ...
Paul W. Blair, Maryam Keshtkar-Jahromi, Kevin J. Psoter, Ronald B. Reisler, Travis K. Warren, Sara C. Johnston, Arthur J. Goff, Lydia G. Downey, Sina Bavari, Anthony P. Cardile   +9 more
doaj   +1 more source

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]

, 2017
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K, Basler, Christopher F, Batra, Jyoti, Leung, Daisy W, Luthra, Priya, Wu, Chao, Xu, Wei   +6 more
core   +2 more sources

Animal models for Ebola and Marburg virus infections

Frontiers in Microbiology, 2013
Ebola and Marburg hemorrhagic fevers (EHF and MHF) are caused by the Filoviridae family, Ebolavirus and Marburgvirus (ebolavirus and marburgvirus), respectively. These severe diseases have high mortality rates in humans.
Eri eNakayama, Masayuki eSaijo
doaj   +1 more source

Challenges, Progress, and Opportunities: Proceedings of the Filovirus Medical Countermeasures Workshop

Viruses, 2014
On August 22–23, 2013, agencies within the United States Department of Defense (DoD) and the Department of Health and Human Services (HHS) sponsored the Filovirus Medical Countermeasures (MCMs) Workshop as an extension of the activities of the Filovirus ...
Rona Hirschberg, Lucy A. Ward, Nicole Kilgore, Rebecca Kurnat, Helen Schiltz, Mark T. Albrecht, George W. Christopher, Ed Nuzum   +7 more
doaj   +1 more source

A Call to Action to Enhance Filovirus Disease Outbreak Preparedness and Response

Viruses, 2014
The frequency and magnitude of recognized and declared filovirus-disease outbreaks have increased in recent years, while pathogenic filoviruses are potentially ubiquitous throughout sub-Saharan Africa.
Paul Roddy
doaj   +1 more source

Newly discovered Ebola virus associated with hemorrhagic fever outbreak in Uganda [PDF]

, 2008
In this report we describe a newly discovered ebolavirus species which caused a large hemorrhagic fever outbreak in western Uganda. The virus is genetically distinct, differing by more than 30% at the genome level from all other known ebolavirus species.
Albariñ, César G., Bakamutumaho, Barnabas, Comer, James A., Conlan, Sean, Downing, Robert, Kayiwa, John, Khristova, Marina L., Ksiazek, Thomas G., Lipkin, W. Ian, Lutwama, Julius, Nichol, Stuart T., Okware, Samuel, Quan, Phuong-Lan, Reeder, Serena A., Rollin, Pierre E., Sealy, Tara K., Tappero, Jordan W., Towner, Jonathan S.   +17 more
core   +4 more sources

Anticipating the species jump: surveillance for emerging viral threats. [PDF]

, 2012
Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by what methods?
Bush, RM, Cobey, S, Flanagan, ML, Glass, GE, Leighton, TJ, Parrish, CR   +5 more
core   +1 more source

An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures

Viruses, 2012
The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
doaj   +1 more source

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]

, 2020
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel, Amman, Brian R, Bairoh, Fatmata V, Bakarr, Ibrahim A, Bangura, Abdulai A, Bangura, Camilla, Bangura, Doris, Bangura, James, Belaganahalli, Manjunatha, Bird, Brian H, Chow, Andrew, Conteh, Immah, Coomber, Moinya, Dhanota, Jasjeet, Edwin, Lavalie, Foday, Ibrahim, Gbakima, Aiah A, Gibson, Alexandra, Goldstein, Tracey, Graziano, James, Guetiya Wadoum, Raoul Emeric, Jambai, Amara, Johnny, Jonathan, Kamanda, Emmanuel S, Kamara, Sorie M, Kanu, Marilyn, Kanu, Osman, Kargbo, Dickson, Koroma, Alusine H, Lebbie, Aiah, Lungai, Victor, Mazet, Jonna AK, Mereweather-Thompson, Vanessa, Musa, Jonathan, Nichol, Stuart T, Ontiveros, Victoria, Osborne, Augustus, Patel, Ketan, Robert, Willie, Saidu, Emmanuel, Schuh, Amy J, Sealy, Tara K, Singh, Tushar, Taboy, Celine H, Towner, Jonathan S, Tremeau-Bravard, Alexandre, Turay, Joseph, Turay, Mohamed, Wadsworth, Richard, Williams, Samuel Maxwell Tom   +49 more
core  

Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit [PDF]

, 2014
Pseudotype viruses (PVs) are chimeric, replication-deficient virions that mimic wild-type virus entry mechanisms and can be safely employed in neutralisation assays, bypassing the need for high biosafety requirements and performing comparably to ...
Assar, Berge, Brauburger, Capecchi, Cliquet, Cox, Croyle, Demaison, Desvaux, Edward Wright, Fellowes, Gao, Higashikawa, Jackson, Kaku, Kishishita, Loi, Lowen, Mather, Molesti, Nigel J. Temperton, Noti, Papenburg, Pear, Scott, Scott, Shin, Simon D. Scott, Stoker, Stuart T. Mather, Temperton, Temperton, Terregino, To, Tong, Tyrrell, Wei, WHO, WHO, Wilschut, Wright, Wright, Wright, Yuen, Zufferey   +44 more
core   +3 more sources