Results 61 to 70 of about 1,452 (166)

An Interagency Collaboration to Facilitate Development of Filovirus Medical Countermeasures

Viruses, 2012
The Filovirus Animal Non-Clinical Group (FANG) is a US interdepartmental and interagency group established to support and facilitate the advanced development of filovirus Medical Countermeasures (MCM), both vaccines and therapeutics.
Edwin O. Nuzum, Nicole Kilgore
doaj   +1 more source

Potential Vaccines and Post-Exposure Treatments for Filovirus Infections

Viruses, 2012
Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral ...
Gene G. Olinger, Brian M. Friedrich, John C. Trefry, Lisa E. Hensley, Anna N. Honko, Darci R. Smith, Julia E. Biggins   +6 more
doaj   +1 more source

Evidence that ebolaviruses and cuevaviruses have been diverging from marburgviruses since the Miocene [PDF]

PeerJ, 2014
An understanding of the timescale of evolution is critical for comparative virology but remains elusive for many RNA viruses. Age estimates based on mutation rates can severely underestimate divergences for ancient viral genes that are evolving under ...
Derek J. Taylor, Matthew J. Ballinger, Jack J. Zhan, Laura E. Hanzly, Jeremy A. Bruenn   +4 more
doaj   +2 more sources

Unveiling a drift-resistant cryptotope within Marburgvirus nucleoprotein recognized by llama single-domain antibodies [PDF]

Acta Crystallographica Section A Foundations and Advances, 2018
(Uploaded by Plazi for the Bat Literature Project) Marburg virus (MARV) is a highly lethal hemorrhagic fever virus that is increasingly re-emerging in Africa, has been imported to both Europe and the US, and is also a Tier 1 bioterror threat. As a negative sense RNA virus, MARV has error prone replication which can yield progeny capable of evading ...
Alex Taylor, J.A. Garza, Laura J. Sherwood, John Hart, Andrew Hayhurst   +4 more
openalex   +7 more sources

Thermostable bivalent filovirus vaccine protects against severe and lethal Sudan ebolavirus and marburgvirus infection. [PDF]

Vaccine
Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are no vaccines for two other highly pathogenic members of the Filoviridae, Sudan ebolavirus (SUDV) and Marburg marburgvirus (MARV).
To A, Wong TAS, Ball AH, Lieberman MM, Yalley-Ogunro J, Cabus M, Nezami S, Paz F, Elyard HA, Borisevich V, Agans KN, Deer DJ, Woolsey C, Cross RW, Geisbert TW, Donini O, Lehrer AT.   +16 more
europepmc   +3 more sources

The Study of Viral RNA Diversity in Bird Samples Using De Novo Designed Multiplex Genus‐Specific Primer Panels

Advances in Virology, Volume 2018, Issue 1, 2018., 2018
Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases.
Andrey A. Ayginin, Ekaterina V. Pimkina, Alina D. Matsvay, Anna S. Speranskaya, Marina V. Safonova, Ekaterina A. Blinova, Ilya V. Artyushin, Vladimir G. Dedkov, German A. Shipulin, Kamil Khafizov, Gary S. Hayward   +10 more
wiley   +1 more source

Living with Bats: The Case of Ve Golokuati Township in the Volta Region of Ghana

Journal of Environmental and Public Health, Volume 2017, Issue 1, 2017., 2017
Transmission of zoonotic pathogens from bats to humans through direct and indirect contact with bats raises public apprehension about living close to bats. In the township of Ve Golokuati in Ghana, several “camps” of Epomophorus gambianus roost in fruit trees that provide ecosystems services for residents.
Jesse S. Ayivor, Fidelia Ohemeng, Elaine Tweneboah Lawson, Linda Waldman, Melissa Leach, Yaa Ntiamoa-Baidu, Tongzhang Zheng   +6 more
wiley   +1 more source

Effective Binding of a Phosphatidylserine‐Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

Journal of Immunology Research, Volume 2015, Issue 1, 2015., 2015
Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine‐targeting antibody (PGN401, bavituximab) has previously been shown to have broad‐spectrum antiviral activity.
S. D. Dowall, V. A. Graham, K. Corbin-Lickfett, C. Empig, K. Schlunegger, C. B. Bruce, L. Easterbrook, R. Hewson, Caroline Rowland   +8 more
wiley   +1 more source

Marburg virus outbreaks in Africa

Bulletin of the National Research Centre, 2023
Marburg virus disease (MVD) is a zoonotic viral hemorrhagic illness, caused by a negative sense, single-stranded RNA virus which has an envelope. The Marburg virus belongs to the genus Marburgvirus of the family Filoviridae.
Ibrahim Idris, Ridwan Olamilekan Adesola, Joanna Nicole D’Souza   +2 more
doaj   +1 more source

Local Mutational Pressures in Genomes of Zaire Ebolavirus and Marburg Virus

Advances in Bioinformatics, Volume 2015, Issue 1, 2015., 2015
Heterogeneities in nucleotide content distribution along the length of Zaire ebolavirus and Marburg virus genomes have been analyzed. Results showed that there is asymmetric mutational A‐pressure in the majority of Zaire ebolavirus genes; there is mutational AC‐pressure in the coding region of the matrix protein VP40, probably, caused by its high ...
Vladislav Victorovich Khrustalev, Eugene Victorovich Barkovsky, Tatyana Aleksandrovna Khrustaleva, Huixiao Hong   +3 more
wiley   +1 more source