Results 71 to 80 of about 1,452 (166)

Natural History of Marburg Virus Infection to Support Medical Countermeasure Development

Viruses, 2022
The Biomedical Advanced Research and Development Authority, part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, recognizes that the evaluation of medical countermeasures under the ...
Jason E. Comer, Trevor Brasel, Shane Massey, David W. Beasley, Chris M. Cirimotich, Daniel C. Sanford, Ying-Liang Chou, Nancy A. Niemuth, Joseph Novak, Carol L. Sabourin, Michael Merchlinsky, James P. Long, Eric J. Stavale, Daniel N. Wolfe   +13 more
doaj   +1 more source

On the Mathematical Analysis of Ebola Hemorrhagic Fever: Deathly Infection Disease in West African Countries

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
For a given West African country, we constructed a model describing the spread of the deathly disease called Ebola hemorrhagic fever. The model was first constructed using the classical derivative and then converted to the generalized version using the beta‐derivative.
Abdon Atangana, Emile Franc Doungmo Goufo, Suares Clovis Oukouomi Noutchie   +2 more
wiley   +1 more source

Seroreactivity against Marburg or related filoviruses in West and Central Africa

Emerging Microbes and Infections, 2020
A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries.
Imke Steffen, Kai Lu, Nicole A. Hoff, Prime Mulembakani, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A. Brennan, John Hackett, William M. Switzer, Sentob Saragosti, Guy O. Mbensa, Syria Laperche, Anne W. Rimoin, Graham Simmons   +14 more
doaj   +1 more source

Cellular Factors Implicated in Filovirus Entry

Advances in Virology, Volume 2013, Issue 1, 2013., 2013
Although filoviral infections are still occurring in different parts of the world, there are no effective preventive or treatment strategies currently available against them. Not only do filoviruses cause a deadly infection, but they also have the potential of being used as biological weapons.
Suchita Bhattacharyya, Thomas J. Hope, Amiya K. Banerjee   +2 more
wiley   +1 more source

Antimicrobial peptides for novel antiviral strategies in the current post‐COVID‐19 pandemic

Journal of Peptide Science, Volume 30, Issue 1, January 2024.
This review describes the main physicochemical characteristics of antimicrobial peptides, with particular focus on peptides derived from amphibian skin. Summarizing the various antiviral activities of these peptides and the underlying mechanism, this review emphasizes the high potential of these small molecules for the development of new antiviral ...
Maria Rosa Loffredo, Lucia Nencioni, Maria Luisa Mangoni, Bruno Casciaro   +3 more
wiley   +1 more source

Protective Role of Cytotoxic T Lymphocytes in Filovirus Hemorrhagic Fever

BioMed Research International, Volume 2011, Issue 1, 2011., 2011
Infection with many emerging viruses, such as the hemorrhagic fever disease caused by the filoviruses, Marburg (MARV), and Ebola virus (EBOV), leaves the host with a short timeframe in which to mouse a protective immune response. In lethal cases, uncontrolled viral replication and virus‐induced immune dysregulation are too severe to overcome, and ...
Kelly Lyn Warfield, Gene Garrard Olinger, Hanchun Yang   +2 more
wiley   +1 more source

Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

BMC Infectious Diseases, 2018
Background Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread.
Peace Babirye, Carol Musubika, Samuel Kirimunda, Robert Downing, Julian J Lutwama, Edward K Mbidde, Jacqueline Weyer, Janusz T Paweska, Moses L Joloba, Misaki Wayengera   +9 more
doaj   +1 more source

Evolutionary maintenance of filovirus-like genes in bat genomes

BMC Evolutionary Biology, 2011
Background Little is known of the biological significance and evolutionary maintenance of integrated non-retroviral RNA virus genes in eukaryotic host genomes.
Taylor Derek J, Dittmar Katharina, Ballinger Matthew J, Bruenn Jeremy A   +3 more
doaj   +1 more source

Assessing the feasibility of Phase 3 vaccine trials against Marburg Virus Disease: A modelling study

Vaccine: X, 2023
Background: Outbreaks of Marburg virus disease (MVD) are rare and small in size, with only 18 recorded outbreaks since 1967, only two of which involved more than 100 cases.
George Y. Qian, Thibaut Jombart, W. John Edmunds   +2 more
doaj  

Filoviral Immune Evasion Mechanisms

Viruses, 2011
The Filoviridae family of viruses, which includes the genera Ebolavirus (EBOV) and Marburgvirus (MARV), causes severe and often times lethal hemorrhagic fever in humans. Filoviral infections are associated with ineffective innate antiviral responses as a
Christopher F. Basler, Gaya K. Amarasinghe, Craig S. Brown, Reed S. Shabman, Parameshwaran Ramanan, Daisy W. Leung   +5 more
doaj   +1 more source