Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
npj VaccinesMarek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most important immunosuppressive and rapid-onset neoplastic diseases in poultry.
Zhi-Jian Zhu +6 more
doaj +2 more sources
Temperature-induced reactivation of Marek's disease virus-transformed T cells ex vivo [PDF]
Frontiers in Veterinary Science, 2023 Marek's disease virus (MDV) establishes latency in chicken T lymphocytes that can lead to T cell transformation and cancer. Transformed Marek's disease chicken cell lines (MDCCs) can be expanded ex vivo and provide a valuable model to study latency ...
Yung-Tien Tien +2 more
doaj +2 more sources
Viral miRNA delivered by exosomes from Marek's disease virus-transformed lymphoma cell line exerts regulatory function in internalized primary chicken embryo fibroblast cells [PDF]
Tumour Virus ResearchIn the past decade, research has demonstrated that viral miRNAs encoded by a number of viral genomes, particularly by most of the herpesvirus including Marek's disease virus (MDV), play important regulatory roles in viral infection, replication, and ...
Man Teng +6 more
doaj +2 more sources
Occurrence of Marek's disease in vaccinated Algerian broiler breeder flocks: A histopathological survey [PDF]
Veterinary World, 2021 Background and Aim: Marek's disease (MD) is a lymphoproliferative disease that occurs in chickens. In the absence of control measures, MD causes devastating losses to commercial poultry flocks.
Abdelaziz Lounas +3 more
doaj +1 more source
Viruses, 2023 As one of the most important avian immunosuppressive and neoplastic diseases, Marek’s disease (MD), caused by oncogenic Marek’s disease virus (MDV), has caused huge economic losses worldwide over the past five decades.
Jin-ling Liu +9 more
semanticscholar +1 more source
Activated Chicken Gamma Delta T Cells Are Involved in Protective Immunity against Marek’s Disease
Viruses, 2023 Gamma delta (γδ) T cells play a significant role in the prevention of viral infection and tumor surveillance in mammals. Although the involvement of γδ T cells in Marek’s disease virus (MDV) infection has been suggested, their detailed contribution to ...
Ayumi Matsuyama-Kato +12 more
semanticscholar +1 more source
Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus
Science China Life Sciences, 2023 Over the past two decades, numerous non-coding RNAs (ncRNAs) have been identified in different biological systems including virology, especially in large DNA viruses such as herpesviruses.
M. Teng +5 more
semanticscholar +1 more source
Genetic variability of the Avian leukosis virus subgroup J gp85 gene in layer flocks in Lower Egypt [PDF]
Veterinary World, 2020 Aim: This study aimed to determine the prevalence of layer flock tumor disease in Lower Egypt during the period of 2018- 2019 and to undertake molecular characterization and determine the genetic diversity of all identified viruses.
Nahed Yehia +3 more
doaj +1 more source
Analysis of DNA methylation of CD79B in MDV-infected chicken spleen
Journal of Integrative Agriculture, 2021 Marek's disease (MD), an immunosuppressive disease induced by Marek's disease virus (MDV), provides an ideal model for studying diseases caused by a carcinogenic virus. CD79B is a B-cell antigen receptor complex-associated protein β-chain precursor which
Lu-lu WANG +4 more
doaj +1 more source
Outbreak of Marek’s Disease in Chicken Flocks with Uncommon Pattern of Gross Lesions [PDF]
Journal of Veterinary and Animal Sciences, 2023 Marek’s disease is one of the highly contagious and oncogenic diseases of poultry that remains as a threat to the fast-growing poultry sector, even after proper vaccination.
R. Geethanjali +4 more
doaj +1 more source