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Isolation of Marek's disease virus: revisited
Avian Pathology, 2005Splenocytes from chickens infected with low-passage stocks of Marek's disease virus (MDV) RB-1B, a very virulent (vv) strain and vv+ RK-1 were used to compare the efficacy of chick kidney cells (CKC), chicken embryo fibroblasts (CEF) and chicken embryo kidney cells (CEKC) for virus isolation. CKC were superior to CEF and CEKC.
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Veterinary Record, 1975
In field trials involving over 224,000 fowls in 11 different commercial flocks, three vaccines were used, namely a freeze-dried vaccine prepared from a turkey herpes virus, a cell-associated virus vaccine prepared from the same isolate and a cell-associated vaccine prepared from a strain of Marek's disease virus isolated from a fowl. The mortality from
J D, Blaxland, A J, Macleod, T, Hall
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In field trials involving over 224,000 fowls in 11 different commercial flocks, three vaccines were used, namely a freeze-dried vaccine prepared from a turkey herpes virus, a cell-associated virus vaccine prepared from the same isolate and a cell-associated vaccine prepared from a strain of Marek's disease virus isolated from a fowl. The mortality from
J D, Blaxland, A J, Macleod, T, Hall
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The History and Biology of Marek’s Disease Virus
2001Marek’s Disease (MD) was the term chosen in 1960 for a common lymphoproliferative disease principally of the domestic chicken (Gallus domesticus), which is now known to be caused by a cell-associated alpha herpesvirus. The lymphoproliferative process in MD can involve most organs and tissues including peripheral nerves.
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Immune responses against Marek's disease virus
Animal Health Research Reviews, 2010AbstractIt is more than a century since Marek's disease (MD) was first reported in chickens and since then there have been concerted efforts to better understand this disease, its causative agent and various approaches for control of this disease. Recently, there have been several outbreaks of the disease in various regions, due to the evolving nature ...
Payvand, Parvizi +5 more
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Released and Extracted Virions of Marek's Disease Virus
Avian Diseases, 1973SUMMARY A virus cloned from the pathogenic GA strain of Marek's disease virus (MDV) was propagated in duck embryo fibroblast culture. Virions released into the growth medium (RV) and virions extracted from the infected cells (EV) were separately concentrated, purified, and compared.
L F, Lee +3 more
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Pathogenesis of Marek’s Disease Virus Infection
2001The term pathogenesis is most simply defined as the development of disease. Many uncomplicated infectious diseases proceed in a direct fashion from infection to a specific pathologic expression. However, other diseases are relatively complex in terms of pathogenesis; Marek’s disease (MD) most certainly belongs in this category.
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Effect of Phosphonoacetate on Marek's Disease Virus Replication
JNCI: Journal of the National Cancer Institute, 1976Phosphonoacetate (PA), but not any of its analogues tested, effectively inhibited avian herpesvirus replication and viral DNA synthesis in cell cultures. At 100 mug/ml culture medium, PA completely inhibited the replication of Marek's disease virus (MDV), herpesvirus of turkeys, and owl herpesvirus, but had no measurable effect on normal cell growth ...
L F, Lee +4 more
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Marek's disease virus: from miasma to model
Nature Reviews Microbiology, 2006Marek's disease virus (MDV) is an oncogenic herpesvirus that causes various clinical syndromes in its natural host, the chicken. MDV has long been of interest as a model organism, particularly with respect to the pathogenesis and immune control of virus-induced lymphoma in an easily accessible small-animal system.
Osterrieder, Nikolaus +4 more
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Disinfection of Marek's disease virus in poultry dust
Avian Pathology, 1977Dust samples from farms contaminated with Marek's disease virus (MDV) were exposed to various disinfectants under experimental and field conditions. After the disinfection treatment, examination was made for the presence and oncogenicity of surviving MDV by the inoculation of tissue cultures and susceptible chickens.
I, Hlozanek, V, Jurajda, V, Benda
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Immune Responses to Marek’s Disease Virus Infection
2001Marek’s disease (MD), a herpesvirus-induced lymphomatous disease in chickens, has attracted the interest of immunologists since MD virus (MDV) was isolated in 1968 and vaccines became available shortly afterwards (Witter 1985,Witter 2000). The pathogenesis of MD has been reviewed extensively (Calnek 1986,Calnek 1998,Calnek 2000; Schat 1987b). Infection
K A, Schat, C J, Markowski-Grimsrud
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