Results 131 to 140 of about 2,698 (157)
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2001
MDV latency is defined as the persistence of the viral genome in the absence of production of infectious virus except during reactivation. A number of systems for studying MDV latency exist, and most involve the use of lymphoblastoid cells or tumors. It has been difficult to divorce latency and transformation.
R W, Morgan +6 more
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MDV latency is defined as the persistence of the viral genome in the absence of production of infectious virus except during reactivation. A number of systems for studying MDV latency exist, and most involve the use of lymphoblastoid cells or tumors. It has been difficult to divorce latency and transformation.
R W, Morgan +6 more
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Structural proteins of Marek's disease virus
Virology, 1972Abstract Marek's disease virus (MDV) was propagated in roller-bottle cultures of duck embryo fibroblasts and partially purified by sucrose gradient centrifugation. Analysis of viral protein by polyacrylamide gel electrophoresis revealed that at least eight proteins (designated VPI-VPVIII) were present in MDV. The VPI is the major viral protein.
J H, Chen +3 more
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The Genomic Structure of Marek’s Disease Virus
2001All herpesviruses contain linear, double-stranded DNA genome surrounded by a 100-nm diameter icosahedral protein capsid core consisting of 162 capsomers. In thin-section electron micrographs, an electron transparent region, termed the tegument, surrounds the capsid, which in turn is surrounded by a lipid-containing envelope.
R F, Silva, L F, Lee, G F, Kutish
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Veterinary Record, 1975
In field trials involving over 224,000 fowls in 11 different commercial flocks, three vaccines were used, namely a freeze-dried vaccine prepared from a turkey herpes virus, a cell-associated virus vaccine prepared from the same isolate and a cell-associated vaccine prepared from a strain of Marek's disease virus isolated from a fowl. The mortality from
J D, Blaxland, A J, Macleod, T, Hall
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In field trials involving over 224,000 fowls in 11 different commercial flocks, three vaccines were used, namely a freeze-dried vaccine prepared from a turkey herpes virus, a cell-associated virus vaccine prepared from the same isolate and a cell-associated vaccine prepared from a strain of Marek's disease virus isolated from a fowl. The mortality from
J D, Blaxland, A J, Macleod, T, Hall
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Immune responses against Marek's disease virus
Animal Health Research Reviews, 2010AbstractIt is more than a century since Marek's disease (MD) was first reported in chickens and since then there have been concerted efforts to better understand this disease, its causative agent and various approaches for control of this disease. Recently, there have been several outbreaks of the disease in various regions, due to the evolving nature ...
Payvand, Parvizi +5 more
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Isolation of Marek's disease virus: revisited
Avian Pathology, 2005Splenocytes from chickens infected with low-passage stocks of Marek's disease virus (MDV) RB-1B, a very virulent (vv) strain and vv+ RK-1 were used to compare the efficacy of chick kidney cells (CKC), chicken embryo fibroblasts (CEF) and chicken embryo kidney cells (CEKC) for virus isolation. CKC were superior to CEF and CEKC.
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Effect of Phosphonoacetate on Marek's Disease Virus Replication
JNCI: Journal of the National Cancer Institute, 1976Phosphonoacetate (PA), but not any of its analogues tested, effectively inhibited avian herpesvirus replication and viral DNA synthesis in cell cultures. At 100 mug/ml culture medium, PA completely inhibited the replication of Marek's disease virus (MDV), herpesvirus of turkeys, and owl herpesvirus, but had no measurable effect on normal cell growth ...
L F, Lee +4 more
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Marek's disease virus: from miasma to model
Nature Reviews Microbiology, 2006Marek's disease virus (MDV) is an oncogenic herpesvirus that causes various clinical syndromes in its natural host, the chicken. MDV has long been of interest as a model organism, particularly with respect to the pathogenesis and immune control of virus-induced lymphoma in an easily accessible small-animal system.
Osterrieder, Nikolaus +4 more
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Released and Extracted Virions of Marek's Disease Virus
Avian Diseases, 1973SUMMARY A virus cloned from the pathogenic GA strain of Marek's disease virus (MDV) was propagated in duck embryo fibroblast culture. Virions released into the growth medium (RV) and virions extracted from the infected cells (EV) were separately concentrated, purified, and compared.
L F, Lee +3 more
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The History and Biology of Marek’s Disease Virus
2001Marek’s Disease (MD) was the term chosen in 1960 for a common lymphoproliferative disease principally of the domestic chicken (Gallus domesticus), which is now known to be caused by a cell-associated alpha herpesvirus. The lymphoproliferative process in MD can involve most organs and tissues including peripheral nerves.
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