Results 41 to 50 of about 4,947 (174)

Coinfection in the host can result in functional complementation between live vaccines and virulent virus

Virulence, 2022
One of the greatest achievements of the last century is the development of vaccines against viral diseases. Vaccines are essential for battling infectious diseases and many different formulations are available, including live attenuated vaccines. However,
Huai Xu, Andrea L. Krieter, Nagendraprabhu Ponnuraj, Yvette (Yung-Tien) Tien, Taejoong Kim, Keith W. Jarosinski   +5 more
doaj   +1 more source

Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity [PDF]

, 2008
Research Article published by SpringerMarek’s disease (MD) of chickens is a unique natural model of Hodgkin’s and Non Hodgkin’s lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30hi) antigen.
Shyamesh Kumar, Joram J. Buza, Shane C. Burgess, A Jemal, SC Burgess, JJ Buza, LA Shack, SC Burgess, AS Abdelrazeq, SC Burgess, SC Burgess, A O’Garra, W Hansen, AG Jarnicki, S Pfoertner, D Kabelitz, H Liu, T Mizobuchi, S Dominitzki, L Rothwell, MG Kaiser, P Kaiser, I Eldaghayes, FM McCarthy, KA Schat, Z Xing, Z Xing, MF Abdul-Careem, P Quere, PA Antony, AM Levy, LF Lu, K Miyazono, YP Rubtsov, J Marx, GL Hold, T Okamoto, R Horie, B Herreros, BF Skinnider, O Cochet, K Jurianz, T Alvaro, T Alvaro, BE Wahlin, K Chamoto   +45 more
core   +1 more source

Transcriptome Analysis in Spleen Reveals Differential Regulation of Response to Newcastle Disease Virus in Two Chicken Lines. [PDF]

, 2018
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries.
Bunn, David A, Deist, Melissa S, Dekkers, Jack CM, Gallardo, Rodrigo A, Kaiser, Michael G, Kelly, Terra R, Lamont, Susan J, Zhang, Jibin, Zhou, Huaijun   +8 more
core   +3 more sources

A novel method for genome-wide profiling of dynamic host-pathogen interactions using 3′ end enriched RNA-seq

Scientific Reports, 2017
Marek’s disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-
Jie Li, Liangliang He, Yun Zhang, Chunyi Xue, Yongchang Cao   +4 more
doaj   +1 more source

An Overview on Marek’s Disease Virus Evolution and Evidence for Increased Virulence in Brazil

Brazilian Journal of Poultry Science, 2019
Marek’s disease virus (MDV) has been shown to be evolving to higher virulence. One of the genetic sites involved in virulence which enables such characterization is the 339-amino acid Meq protein encoding gene (meq).
ACD Torres, SY Marin, CS Costa, NRS Martins   +3 more
doaj   +1 more source

Integrated Genomic Approaches to Enhance Genetic Resistance in Chickens [PDF]

, 2013
The chicken has led the way among agricultural animal species in infectious disease control and, in particular, selection for genetic resistance. The generation of the chicken genome sequence and the availability of other empowering tools and resources ...
Cheng, Hans, Kaiser, Pete, Lamont, Susan, Lamont, Susan   +3 more
core   +3 more sources

DNMT gene expression and methylome in Marek’s disease resistant and susceptible chickens prior to and following infection by MDV [PDF]

, 2013
Marek’s disease (MD) is characterized as a T cell lymphoma induced by a cell-associated α-herpesvirus, Marek’s disease virus type 1 (MDV1). As with many viral infectious diseases, DNA methylation variations were observed in the progression of MD; these ...
Edwards, John R, Hiken, Jeffrey F, Song, Jiuzhou, Tian, Fei, VanderKraats, Nathan D, Zhan, Fei, Zhang, Huanmin, Zhao, Keji   +7 more
core   +2 more sources

The Need for Evolutionarily Rational Disease Interventions: Vaccination Can Select for Higher Virulence [PDF]

, 2018
This is the final version of the article. Available from Public Library of Science via the DOI in this recordThere is little doubt evolution has played a major role in preventing the control of infectious disease through antibiotic and insecticide ...
Boots, M
core   +1 more source

Role of T Cells in Vaccine-Mediated Immunity against Marek’s Disease

Viruses, 2023
Marek’s disease virus (MDV), a highly cell-associated oncogenic α-herpesvirus, is the etiological agent of T cell lymphomas and neuropathic disease in chickens known as Marek’s disease (MD).
Mohammad Heidari, Huanmin Zhang, Lakshmi T Sunkara, Syed Mudasir Ahmad   +3 more
doaj   +1 more source

Assessment of the dynamics of microparasite infections in genetically homogeneous and heterogeneous populations using a stochastic epidemic model [PDF]

, 2008
The aim of this paper was to explore the effect of genetic heterogeneity in host resistance to infection on the population-level risks and outcomes of epidemics.
Bishop, S. C., Nath, M., Woolliams, J. A.   +2 more
core   +1 more source