Results 51 to 60 of about 542,796 (218)

Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity

Cellular and Molecular Life Sciences, 2020
Marek’s disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens.
Yi Yang, Maoli Dong, Xiaoli Hao, A. Qin, S. Shang   +4 more
semanticscholar   +1 more source

A novel method for genome-wide profiling of dynamic host-pathogen interactions using 3′ end enriched RNA-seq

Scientific Reports, 2017
Marek’s disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into dynamic host-
Jie Li, Liangliang He, Yun Zhang, Chunyi Xue, Yongchang Cao   +4 more
doaj   +1 more source

Genotype-Dependent Tumor Regression in Marek’s Disease Mediated at the Level of Tumor Immunity [PDF]

, 2008
Research Article published by SpringerMarek’s disease (MD) of chickens is a unique natural model of Hodgkin’s and Non Hodgkin’s lymphomas in which the neoplastically-transformed cells over-express CD30 (CD30hi) antigen.
Shyamesh Kumar, Joram J. Buza, Shane C. Burgess, A Jemal, SC Burgess, JJ Buza, LA Shack, SC Burgess, AS Abdelrazeq, SC Burgess, SC Burgess, A O’Garra, W Hansen, AG Jarnicki, S Pfoertner, D Kabelitz, H Liu, T Mizobuchi, S Dominitzki, L Rothwell, MG Kaiser, P Kaiser, I Eldaghayes, FM McCarthy, KA Schat, Z Xing, Z Xing, MF Abdul-Careem, P Quere, PA Antony, AM Levy, LF Lu, K Miyazono, YP Rubtsov, J Marx, GL Hold, T Okamoto, R Horie, B Herreros, BF Skinnider, O Cochet, K Jurianz, T Alvaro, T Alvaro, BE Wahlin, K Chamoto   +45 more
core   +1 more source

An Overview on Marek’s Disease Virus Evolution and Evidence for Increased Virulence in Brazil

Brazilian Journal of Poultry Science, 2019
Marek’s disease virus (MDV) has been shown to be evolving to higher virulence. One of the genetic sites involved in virulence which enables such characterization is the 339-amino acid Meq protein encoding gene (meq).
ACD Torres, SY Marin, CS Costa, NRS Martins   +3 more
doaj   +1 more source

DNMT gene expression and methylome in Marek’s disease resistant and susceptible chickens prior to and following infection by MDV [PDF]

, 2013
Marek’s disease (MD) is characterized as a T cell lymphoma induced by a cell-associated α-herpesvirus, Marek’s disease virus type 1 (MDV1). As with many viral infectious diseases, DNA methylation variations were observed in the progression of MD; these ...
Edwards, John R, Hiken, Jeffrey F, Song, Jiuzhou, Tian, Fei, VanderKraats, Nathan D, Zhan, Fei, Zhang, Huanmin, Zhao, Keji   +7 more
core   +2 more sources

The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV) [PDF]

, 2013
In contrast to typical mammals, the chicken MHC (the BF-BL region of the B locus) has strong genetic associations with resistance and susceptibility to infectious pathogens as well as responses to vaccines.
Butter, Colin, Davison, T. Fred, Kaufman, Jim, Staines, Karen, van Hateren, Andrew   +4 more
core   +1 more source

Role of T Cells in Vaccine-Mediated Immunity against Marek’s Disease

Viruses, 2023
Marek’s disease virus (MDV), a highly cell-associated oncogenic α-herpesvirus, is the etiological agent of T cell lymphomas and neuropathic disease in chickens known as Marek’s disease (MD).
Mohammad Heidari, Huanmin Zhang, Lakshmi T Sunkara, Syed Mudasir Ahmad   +3 more
doaj   +1 more source

Integrated Genomic Approaches to Enhance Genetic Resistance in Chickens [PDF]

, 2013
The chicken has led the way among agricultural animal species in infectious disease control and, in particular, selection for genetic resistance. The generation of the chicken genome sequence and the availability of other empowering tools and resources ...
Cheng, Hans, Kaiser, Pete, Lamont, Susan, Lamont, Susan   +3 more
core   +3 more sources

Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek’s Disease Virus

Journal of Virology, 2019
Viruses can manipulate host cellular metabolism to provide energy and essential biosynthetic requirements for efficient replication. Marek’s disease virus (MDV), an avian alphaherpesvirus, causes a deadly lymphoma in chickens and hijacks host cell ...
Nitish Boodhoo, Nitin Kamble, S. Sharif, S. Behboudi   +3 more
semanticscholar   +1 more source

PERCC1‐associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide

JPGN Reports, EarlyView.
Abstract Congenital diarrheas and enteropathies (CODE) are rare inherited disorders characterized by early‐onset intractable diarrhea. Though progress has been made in elucidating the genetic basis of CODE, much remains to be discovered. Another challenge is the lack of curative therapies—treatment is primarily supportive including enteral and ...
Angela Tran, Vivien Nguyen, Phuong Huynh
wiley   +1 more source