Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]
Journal of Neuroinflammation, 2022 Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis.
Alba Sánchez-Fernández +6 more
doaj +7 more sources
The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model [PDF]
Mediators of Inflammation, 2021 Asthma is a chronic inflammatory disease that cannot be cured. Maresin 1 (MaR1) is a specific lipid synthesized by macrophages that exhibits powerful anti-inflammatory effects in various inflammatory diseases.
Guochun Ou +11 more
doaj +5 more sources
Maresin-1 and Inflammatory Disease [PDF]
International Journal of Molecular Sciences, 2022 Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified.
Natsuko Saito-Sasaki +2 more
exaly +5 more sources
Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6 [PDF]
MedCommHypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from Omega‐3 fatty acids, has been reported to promote inflammation resolution in ...
Zheng Yin +12 more
doaj +4 more sources
Maresin 1 Alleviates Seizure Symptoms by Modulating the Crosstalk Between Inflammation and Ferroptosis [PDF]
Journal of Inflammation ResearchYueying Liu,1,* Shengjie Xu,1,* Yufan Luo,1,* Xue Xiao,1 Xiaofan Jiang,1 Wei Xiao,1 Ruijin Xie,1 Xianhui Deng,2 Zhen Li,3 Yingsi Cao,1 Yuanjin Chang,1 Dongqin Wu,1 Hua Xu,1 Wenjing Zhao4 1Department of Pediatrics, Affiliated ...
Liu Y +13 more
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Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions [PDF]
The Journal of Clinical Investigation, 2023 Resolution of acute inflammation is an active process orchestrated by endogenous mediators and mechanisms pivotal in host defense and homeostasis. The macrophage mediator in resolving inflammation, maresin 1 (MaR1), is a potent immunoresolvent, stimulating resolution of acute inflammation and organ protection.
Nan Chiang +4 more
doaj +5 more sources
Maresin-1 impairs cutaneous wound healing response [PDF]
ImmunoHorizonsAbstract Maresin-1 is a derivative of docosahexaenoic acid with strong anti-inflammatory action in various disease models. However, these effects may not always be beneficial. In instances like cutaneous diseases in which wound healing is important, inflammation is required.
Natsuko Saito-Sasaki +2 more
exaly +4 more sources
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury [PDF]
Journal of Neuroinflammation, 2022 Background Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective treatments for PNI are still limited.
Jinhuan Wei +8 more
doaj +2 more sources
Maresin-1 Ameliorates Chronic Unpredictable Stress-Induced Depressive-like Behaviors Associated with Dynamic Modulation of Hippocampal Microglial Activity and TSPO PET Signals [PDF]
BiomedicinesBackground/Objectives: Maresin-1 (MaR1), a specialized pro-resolving mediator (SPM) derived from omega-3 fatty acids, has demonstrated potent anti-inflammatory and pro-resolving properties.
Anhai Zheng +7 more
doaj +2 more sources
Circulating Maresin-1 and cartilage remodeling biomarkers in rheumatoid arthritis and osteoarthritis [PDF]
Scientific ReportsRheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms.
Omer Esmez +5 more
doaj +2 more sources