Maresin 1 repletion improves muscle regeneration after volumetric muscle loss [PDF]
eLife, 2023 The acute traumatic or surgical loss of skeletal muscle, known as volumetric muscle loss (VML), is a devastating type of injury that results in exacerbated and persistent inflammation followed by fibrosis.
Jesus A Castor-Macias +12 more
doaj +4 more sources
Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]
Journal of Neuroinflammation, 2022 Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis.
Alba Sánchez-Fernández +6 more
doaj +7 more sources
Maresin-1 impairs cutaneous wound healing response [PDF]
ImmunoHorizonsAbstract Maresin-1 is a derivative of docosahexaenoic acid with strong anti-inflammatory action in various disease models. However, these effects may not always be beneficial. In instances like cutaneous diseases in which wound healing is important, inflammation is required.
Natsuko Saito-Sasaki +2 more
exaly +4 more sources
Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis [PDF]
Mediators of Inflammation, 2016 Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models ...
Ruidong Li +8 more
doaj +4 more sources
Maresin 1 alleviates myocardial ischemia-reperfusion injury in rats by suppressing inflammation [PDF]
European Journal of HistochemistryMyocardial ischemia-reperfusion injury (MIRI) induces severe inflammatory damage to cardiac tissue, leading to structural impairment and functional decline.
Hongkai Xiao +5 more
doaj +4 more sources
Maresin 1 and CHI3L1 Levels Exhibit Opposing Trends and Correlations with Renal Dysfunction in Diabetic Nephropathy [PDF]
MedicinaBackground and Objectives: This study aimed to investigate the relationship between Maresin-1 (MaR1), Chitinase-3-like protein 1 (CHI3L1), and inflammatory as well as hematological markers in patients with type 2 diabetes mellitus (T2DM) and diabetic ...
Aykut Bulu +8 more
doaj +3 more sources
Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress [PDF]
CellsPeriodontal disease is characterized by inflammation and bone loss. Central to its pathogenesis is the dysregulated inflammatory response, complicating regenerative therapies.
Shahd AlZahrani +3 more
doaj +3 more sources
Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis [PDF]
The Journal of Clinical InvestigationG protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively ...
Sangsu Bang +17 more
doaj +3 more sources
Prospective study on Maresin-1 and cytokine levels in medication-naïve adolescents with first-episode major depressive disorder [PDF]
Frontiers in Psychiatry, 2023 BackgroundInflammation and immune activation may play a role in the pathological mechanism of Major Depressive Disorder (MDD). Evidence from cross-sectional and longitudinal studies of adolescents and adults has shown that MDD is associated with ...
Tian Qiu +11 more
doaj +2 more sources
12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial [PDF]
Journal of the International Society of Sports NutritionBackground Obesity is characterized by low‑grade chronic inflammation and impaired insulin sensitivity. Maresin‑1 (MaR1), a specialized pro‑resolving mediator, plays a critical role in terminating inflammation and supporting metabolic homeostasis ...
Mehran Alipour +4 more
doaj +2 more sources