Results 31 to 40 of about 1,753 (136)

Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis [PDF]

The Journal of Clinical Investigation
G protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively ...
Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji   +17 more
doaj   +2 more sources

Maresin 1 Ameliorates Diabetic Kidney Disease in Mice by Promoting Macrophage M2 Polarization [PDF]

Mediators of Inflammation
Yueli Pu, Xiumei Ma, Kang Geng, Renliang Meng, Yonglin Li, Chunmei Zheng, Changying Zhao, Fangyuan Teng, Yong Xu   +8 more
doaj   +2 more sources

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1. [PDF]

Int J Mol Sci, 2022
Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA.   +6 more
europepmc   +3 more sources

Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats. [PDF]

Am J Physiol Renal Physiol
This study shows that MaR1, a specialized proresolving mediator, influences lipid metabolism and modifies gene expression in the heart and kidney in a salt-sensitive hypertension model, without affecting blood pressure or organ structure. These findings highlight the potential role of MaR1 in regulating inflammation and circadian rhythms associated ...
Bohovyk R, Kravtsova O, Upadhyay G, Levchenko V, Lowe M, Shapiro A, Halade GV, Staruschenko A.   +7 more
europepmc   +3 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cetirizine and Dexamethasone in Sepsis: Insights into Maresin-1 Signaling and Cytokine Regulation. [PDF]

J Clin Med
Background/Objectives: Sepsis remains one of the leading causes of mortality, yet its etiopathogenesis is still not fully understood. This study aimed to investigate the effects of cetirizine and dexamethasone (alone and in combination) on serum levels of Maresin-1 (MaR-1), TNF-α, IFN-γ, IL-1, IL-2, IL-6, IL-8, and IL-10 in a rat model of sepsis ...
Aydin Y, Borku MK, Ugur K, Eroksuz Y, Emre E, Incili CA, Sahin İ, Acarturk İZ, Aydin S, Lee DY.   +9 more
europepmc   +4 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation [PDF]

The Journal of Immunology, 2016
Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context of infectious inflammation is of interest. In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in regulating leukocyte responses in the context of bacterial ...
Romain A Colas, Jesmond Dalli, Nan Chiang, Iliyan Vlasakov, Julia M Sanger, Ian R Riley, Charles N Serhan   +6 more
openaire   +3 more sources

Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis [PDF]

Osteoarthritis and Cartilage
Shyni Varghese, Yuan-Wen Lee, Anna Gilpin   +2 more
exaly   +2 more sources

Investigation of the Effects of Maresin-1 on Testicular Ischemia Reperfusion Induced Oxidative Stress

Southern Clinics of Istanbul Eurasia, 2020
INTRODUCTION[|]The purpose of this study is to examine the protective effects of maresin 1 on testicular injury induced by ischemia reperfusion. [¤]METHODS[|]24 Sprague-Dawley male rats were divided into 3 groups. The groups are planned as follows; sham,
Ayhan Tanyeli, Ersen Eraslan, Mustafa Can Güler, Fazile Nur Ekinci Akdemir, Derya Güzel Akdoğan, Ömer Topdağı, Elif Polat   +6 more
doaj   +1 more source