Results 31 to 40 of about 1,949 (158)

Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice [PDF]

Molecular Metabolism, 2023
Objective: Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation and white adipose tissue (WAT)
Laura M. Laiglesia, Xavier Escoté, Neira Sáinz, Elisa Felix-Soriano, Eva Santamaría, María Collantes, Marta Fernández-Galilea, Ignacio Colón-Mesa, Leyre Martínez-Fernández, Tania Quesada-López, Sergio Quesada-Vázquez, Carlos Rodríguez-Ortigosa, José M. Arbones-Mainar, Ángela M. Valverde, J Alfredo Martínez, Jesmond Dalli, Laura Herrero, Silvia Lorente-Cebrián, Francesc Villarroya, María J. Moreno-Aliaga   +19 more
doaj   +2 more sources

Cetirizine and Dexamethasone in Sepsis: Insights into Maresin-1 Signaling and Cytokine Regulation. [PDF]

J Clin Med
Background/Objectives: Sepsis remains one of the leading causes of mortality, yet its etiopathogenesis is still not fully understood. This study aimed to investigate the effects of cetirizine and dexamethasone (alone and in combination) on serum levels of Maresin-1 (MaR-1), TNF-α, IFN-γ, IL-1, IL-2, IL-6, IL-8, and IL-10 in a rat model of sepsis ...
Aydin Y, Borku MK, Ugur K, Eroksuz Y, Emre E, Incili CA, Sahin İ, Acarturk İZ, Aydin S, Lee DY.   +9 more
europepmc   +4 more sources

Maresin 1 Exerts a Tissue-Specific Regulation of Adipo-Hepato-Myokines in Diet-Induced Obese Mice and Modulates Adipokine Expression in Cultured Human Adipocytes in Basal and Inflammatory Conditions [PDF]

Biomolecules, 2023
This study analyses the effects of Maresin 1 (MaR1), a docosahexaenoic acid (DHA)-derived specialized proresolving lipid mediator with anti-inflammatory and insulin-sensitizing actions, on the expression of adipokines, including adiponectin, leptin ...
Leyre Martínez-Fernández, Miguel Burgos, Neira Sáinz, Laura M. Laiglesia, José Miguel Arbones-Mainar, Pedro González-Muniesa, María J. Moreno-Aliaga   +6 more
doaj   +2 more sources

Maresin-1 Ameliorates Chronic Unpredictable Stress-Induced Depressive-like Behaviors Associated with Dynamic Modulation of Hippocampal Microglial Activity and TSPO PET Signals [PDF]

Biomedicines
Background/Objectives: Maresin-1 (MaR1), a specialized pro-resolving mediator (SPM) derived from omega-3 fatty acids, has demonstrated potent anti-inflammatory and pro-resolving properties.
Anhai Zheng, Tian Qiu, Lei Shi, Lixia Wang, Zhu Xia, Zhiping Peng, Li Kuang, Jiamei Guo   +7 more
doaj   +2 more sources

Plasma and aqueous humor levels of Maresin-1 in patients with diabetic retinopathy [PDF]

Scientific Reports
The aim of this study was to evaluate plasma and aqueous Maresin-1 (MaR1) levels in patients with diabetic retinopathy (DR) and to examine the ability of these levels to distinguish proliferative diabetic retinopathy.
Sabiha Güngör Kobat, Fatih Cem Gül, Fatih Çelik, Seda Liman Uzun, Fatma Savur, Kader Kasar, Sara Koylu Güngör, Mehmet Balbaba, Süleyman Aydın   +8 more
doaj   +2 more sources

The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. [PDF]

Proc Natl Acad Sci U S A, 2023
The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation and enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncytial virus (RSV)-induced inflammation.
Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD.   +11 more
europepmc   +3 more sources

Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression

Scientific Reports, 2018
The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong ...
Natsuko Saito-Sasaki, Yu Sawada, Emi Mashima, Takashi Yamaguchi, Shun Ohmori, Haruna Yoshioka, Sanehito Haruyama, Etsuko Okada, Motonobu Nakamura   +8 more
doaj   +2 more sources

Serum Resolvin D1 and Maresin 1 Levels During Migraine Attacks and the Interictal Period: A Paired Analysis in Emergency Department Patients [PDF]

Biomedicines
Background/Objectives: Neurogenic inflammation plays a key role in migraine pathophysiology. This study aimed to evaluate serum Resolvin D1 (RvD1) and Maresin 1 (MaR1) levels during acute migraine attacks and in the interictal period in the same patients,
Miraç Koç, Özge Özen Gökmuharremoğlu, Neslihan Cihan Çalışgan   +2 more
doaj   +2 more sources

Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice

Microorganisms, 2020
The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice.
Irene C. León, Sergio Quesada-Vázquez, Neira Sáinz, Elizabeth Guruceaga, Xavier Escoté, María Jesús Moreno-Aliaga   +5 more
doaj   +4 more sources

Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway [PDF]

Renal Failure
Purpose Sepsis-induced acute kidney injury (S-AKI) is a severe complication of sepsis. This study aimed to explore the protective effects of Maresin-1 (MaR-1) on S-AKI and elucidate its potential molecular mechanisms, focusing on ferroptosis and the Nrf2/
Lili Tang, Dongrui He, Pengyu Wan, Xingzhu Gou, Yuhao Wang, Xiaoyue Li   +5 more
doaj   +2 more sources