Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis [PDF]
Mediators of Inflammation, 2017 Background. Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Aim.
Shi Tang +7 more
doaj +2 more sources
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng +6 more
doaj +3 more sources
Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer [PDF]
Mediators of Inflammation, 2020 Aims. To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods.
Tian Miao +9 more
doaj +3 more sources
Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1. [PDF]
Int J Mol Sci, 2022 Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Olsen MV +6 more
europepmc +3 more sources
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway [PDF]
Frontiers in Pharmacology, 2021 Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities and is associated with extremely high mortality.
Jiameng Li +6 more
doaj +2 more sources
Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats. [PDF]
Am J Physiol Renal PhysiolThis study shows that MaR1, a specialized proresolving mediator, influences lipid metabolism and modifies gene expression in the heart and kidney in a salt-sensitive hypertension model, without affecting blood pressure or organ structure. These findings highlight the potential role of MaR1 in regulating inflammation and circadian rhythms associated ...
Bohovyk R +7 more
europepmc +3 more sources
Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus [PDF]
Mediators of Inflammation, 2015 In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been
Chul-Kyu Park
doaj +2 more sources
Maresin 1 induces resolution of hepatic fibrosis through RORα-dependent reprogramming of resident macrophages [PDF]
Frontiers in PharmacologyHepatic fibrosis is a progressive pathological condition characterized by chronic inflammation and excessive extracellular matrix deposition (ECM), which may progress to cirrhosis and liver failure. Although specialized pro-resolving lipid mediators have
Francisca Herrera Vielma +13 more
doaj +2 more sources
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury [PDF]
Journal of Neuroinflammation, 2022 Background Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective treatments for PNI are still limited.
Jinhuan Wei +8 more
doaj +2 more sources
Circulating Maresin-1 and cartilage remodeling biomarkers in rheumatoid arthritis and osteoarthritis [PDF]
Scientific ReportsRheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms.
Omer Esmez +5 more
doaj +2 more sources