Results 41 to 50 of about 1,753 (136)
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng +6 more
doaj +1 more source
The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. [PDF]
Proc Natl Acad Sci U S A, 2023 The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation and enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncytial virus (RSV)-induced inflammation.
Krishnamoorthy N +11 more
europepmc +3 more sources
Frontiers in Neuroscience, 2020 BackgroundThe exposure of the nucleus pulposus (NP) causes an immune and inflammatory response, which is intrinsically linked to the pathogenesis of radicular pain. As a newly discovered pro-resolving lipid mediator, maresin 1 (MaR1) could exert powerful
Yi-hao Wang +8 more
doaj +1 more source
Mediators of Inflammation, 2017 Background. Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Aim.
Shi Tang +7 more
doaj +1 more source
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders [PDF]
British Journal of Anaesthesia, 2019 Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effects of MaR1 on postoperative neuroinflammation, macrophage activity, and cognitive function in mice.Adult male
Yang, T. +12 more
openaire +2 more sources
Mediators of Inflammation, 2015 In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been
Chul-Kyu Park
doaj +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2022 Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal disorder, an inflammation might also contribute to PCOS and its metabolic associations.
Adem Yavuz +4 more
doaj +1 more source
Cells, 2022 An interconnection between tissue inflammation and regeneration has been established through the regulation of defense and repair mechanisms within diseased dental tissue triggered by the release of immune-resolvent mediators. To better our understanding
Shahd AlZahrani +4 more
doaj +1 more source
Maresin 1 resolves aged‐associated macrophage inflammation to improve bone regeneration [PDF]
The FASEB Journal, 2020 Abstract Inflammaging is associated with poor tissue regeneration observed in advanced age. Specifically, protracted inflammation after acute injury has been associated with decreased bone fracture healing and increased rates of nonunion in elderly patients.
Huang, Rong +3 more
openaire +2 more sources
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway
Molecular Medicine, 2021 Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown to suppress I/R injury.
Da Tang +7 more
doaj +1 more source