Results 51 to 60 of about 1,753 (136)

Maresin 1 induces a novel pro‐resolving phenotype in human platelets [PDF]

Journal of Thrombosis and Haemostasis, 2017
Essentials Specialized proresolving mediators (SPMs) promote the resolution of inflammation. This study sought to investigate the effects of SPMs on human platelet function. The SPM, Maresin 1, enhanced hemostatic, but suppressed inflammatory functions of platelets.
K L, Lannan, S L, Spinelli, N, Blumberg, R P, Phipps   +3 more
openaire   +2 more sources

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research
Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer’s disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer’s disease to prevent/stop ...
Ying Wang, Xiang Zhang, Henrik Biverstål, Nicolas G. Bazan, Shuai Tan, Nailin Li, Makiko Ohshima, Marianne Schultzberg, Xiaofei Li   +8 more
doaj   +1 more source

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice [PDF]

Circulation Research, 2016
Rationale: Atheroprogression is a consequence of nonresolved inflammation, and currently a comprehensive overview of the mechanisms preventing resolution is missing. However, in acute inflammation, resolution is known to be orchestrated by a switch from inflammatory to resolving lipid mediators ...
Viola, Joana R., Lemnitzer, Patricia, Jansen, Yvonne, Csaba, Gergely, Winter, Carla, Neideck, Carlos, Silvestre-Roig, Carlos, Dittmar, Gunnar, Döring, Yvonne, Drechsler, Maik, Weber, Christian, Zimmer, Ralf, Cenac, Nicolas, Soehnlein, Oliver   +13 more
openaire   +3 more sources

Subfatin, asprosin, alamandine and maresin-1 in cerebral ischemia, intracranial and subarachnoid hemorrhages.

European review for medical and pharmacological sciences, 2023
Cerebrovascular diseases (CVDs) remain an important public health issue due to the increasing number of deaths worldwide. Changes in the synthesis and release of peptides in CVDs may play an important role in elucidating the physiopathology of the disease. Therefore, this study was to investigate the fate of maresin-1 (MaR-1), subfatin (SUB), asprosin (
Albayrak, S., Aydin, M.A., Ugur, K., Hanbeyoglu, O., Aydin, S., Erol, E., Kilinc, A., Acar, V., Sahin, İ., Aydin, S.   +9 more
openaire   +2 more sources

Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury

Cell & Bioscience, 2021
Background Ferroptosis is unique among different types of regulated cell death and closely related to organ injury. Whether ferroptosis occurs in sepsis-associated acute kidney injury (SA-AKI) is not clear.
Ji Xiao, Qian Yang, Ye’an Zhang, Haoran Xu, Yang Ye, Linchao Li, Yi Yang, Shengwei Jin   +7 more
doaj   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Clinical improvement and scalp microbiome restructuring following a 28‐day piroctone olamine shampoo intervention

International Journal of Cosmetic Science, EarlyView.
A 28‐day clinical study in 41 individuals with oily dandruff showed that a piroctone olamine shampoo improved clinical symptoms while selectively reshaping the scalp bacterial and fungal microbiome toward a less dysbiotic profile. Abstract Objective To evaluate the clinical efficacy of a piroctone olamine–containing shampoo in individuals with oily ...
Spyridon Markos, Lina Praefke, Yiannis Kapetanstatakis, Michail Tsanakas, Evangelos Beletsiotis   +4 more
wiley   +1 more source

The role of presepsin and Maresin-1 levels in blood and synovial fluid in early diagnosis of septic arthritis

Acta Orthopaedica et Traumatologica Turcica
Objective: Early and accurate diagnosis of septic arthritis is essential to prevent irreversible joint damage and systemic complications. This study aimed to evaluate the diagnostic performance of serum and synovial fluid presepsin and Maresin-1 levels ...
Ceren Aydın, Ayşe Sağmak Tartar, Oğuz Aydın, Muhammed Kazez   +3 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source