Results 71 to 80 of about 1,753 (136)

Inflammaging: Experimental Insights and Translational Advances

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley   +1 more source

Omega‐3 Long‐Chain Polyunsaturated Fatty Acid Metabolite 16‐Hydroxydocosahexaenoic Acid Strengthens Non‐Small Cell Lung Cancer Radiosensitivity Through Peroxisome Proliferator‐Activated Receptor γ

Food Frontiers, Volume 7, Issue 4, July 2026.
This study revealed a novel mechanism by which ω‐3 LCPUFA metabolism regulated NSCLC cell radiosensitivity. Specific ω‐3 LCPUFA metabolite 16‐HDHA plasma levels were elevated in the radiosensitive NSCLC patients and enhanced the cytotoxic effects of radiation on NSCLC cells.
Mengqin Wang, Jiang Luo, Mini Zhang, Shuling Li, Jiawen Tang, Qingwei Wang, Yuzhu Wu, Ziyu Jiang, Conghua Xie, Yan Gong   +9 more
wiley   +1 more source

Maresin 1 Resolves Inflammation and Aids Bone Healing in Periapical Lesions

Journal of Dental Research
Chronic apical periodontitis (CAP) is a persistent inflammatory condition caused by microbial infections in the root canal system, leading to bone loss and tissue damage. In this study, we tested the hypothesis that maresin 1 (MaR1), a specialized proresolving mediator, facilitates inflammatory resolution and promotes bone healing ...
E. Demir, I. İlgenli, Z. Guney, S. Mohammadi, K. Lauwens, N. Yakar, C. Alvarez Rivas, O. Unlu, A. Kantarci   +8 more
openaire   +3 more sources

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Additional file 1 of Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis

, 2022
Additional file 1. Fig. S1. MaR1 reduces the accumulation of immune cells in the spinal cord of mice at the peak of EAE. Fig. S2. MaR1 modulates T cells responses in the spinal cord of EAE mice. Fig. S3. MaR1 modulates the macrophages and microglia phenotypes towards a more anti-inflammatory phenotype. Fig. S4. Effects of the treatment with MaR1 in the
Sánchez-Fernández, Alba, Zandee, Stephanie, Mastrogiovanni, Mauricio, Charabati, Marc, Rubbo, Homero, Prat, Alexandre, López-Vales, Rubèn   +6 more
openaire   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Divergent Inflammatory and Bioenergetic Metabolomic Signatures Distinguish Methamphetamine‐Associated From Idiopathic Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Methamphetamine‐associated pulmonary arterial hypertension (Meth‐APAH) is an increasingly recognized cause of pulmonary arterial hypertension (PAH) and is associated with worse outcomes than idiopathic PAH (IPAH). Although both share histopathologic features of pulmonary vascular remodeling, the molecular basis for their clinical divergence ...
Hannah K. Robertson, Emma Yuguchi, Ian Gurholt, William C. Nichols, Nick H. Kim, Timothy Fernandes, Atul Malhotra, Mona Alotaibi   +7 more
wiley   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source

Maresin 1 Mitigates Sepsis-Associated Acute Kidney Injury in Mice via Inhibition of the NF-κB/STAT3/MAPK Pathways

Frontiers in Pharmacology, 2019
Acute kidney injury (AKI) is one of the most common and serious complications of sepsis in which the inflammatory cascade plays a crucial role. There is now increasing evidence that lipid mediators derived from the omega-3 fatty acid docosahexaenoic acid
ShuJun Sun, ShuJun Sun, JiaMei Wang, JingXu Wang, JingXu Wang, FuQuan Wang, FuQuan Wang, ShangLong Yao, ShangLong Yao, HaiFa Xia, HaiFa Xia   +10 more
doaj   +1 more source

The Pro-resolving Mediators Maresin 1, Maresin 2 and Annexin A1 in Maintenance of Ocular Surface Health

, 2022
The omega-3 fatty acids Maresin 1 and Maresin 2 and the protein Annexin A1 are pro-resolving mediators which play an active role in resolution of inflammation. The mediators enhance elimination of apoptotic cells, activation of immune cells and limit invasion of leukocytes.
openaire   +2 more sources