Results 1 to 10 of about 4,269 (185)

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages [PDF]

PLoS ONE, 2014
Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Arnardottir, Hildur H., Cheng, Chien-Yee Cindy, Dalli, Jesmond, Deng, Bin, Li, Yongsheng, Serhan, Charles N., Wang, Chin-Wei   +6 more
core   +16 more sources

Protective Potential of Maresins in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
Cardiovascular diseases are the leading causes of global mortality. Growing evidence suggests that unresolved inflammation contributes to the chronicity, progression and morbidity of many cardiovascular diseases, thus emphasizing the urgent need to illuminate the mechanisms controlling inflammation and its resolution, for the sake of new effective ...
Min Liu, Huixiang He, Lihong Chen
openaire   +4 more sources

Maresin-1 and Inflammatory Disease [PDF]

International Journal of Molecular Sciences, 2022
Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified.
Saito-Sasaki, Natsuko, Sawada, Yu, Nakamura, Motonobu   +2 more
openaire   +2 more sources

Maresins: The Mainstay in Periodontal Resolution [PDF]

Cureus, 2022
Not much was known about the resolution of inflammation until the recent past when significant breakthroughs led to the unveiling of the exact mechanism of this. It is now known that the resolution of inflammation involves specific mediators of resolution such as lipoxins, protectins, resolvins, and maresins, making it an active process.
Gireddy, Hima Bindu, Rajaram, Haripriya, Koduganti, Rekha R, Ambati, Manasa, R, Anilkumar, Harika, Tata Sai Lakshmi   +5 more
openaire   +2 more sources

Synthesis of Optically Active Maresin 2 and Maresin 2n-3 DPA [PDF]

Synlett, 2020
AbstractMaresins are among the most potent antiinflammatory lipid metabolites. We report stereoselective syntheses of maresin 2 and maresin 2n-3 DPA. The anti-diol was constructed through epoxide ring opening of an optically active β,γ-epoxy aldehyde, synthesized in situ by Swern oxidation of the corresponding alcohol.
Narihito Ogawa, Takahito Amano, Yuichi Kobayashi   +2 more
openaire   +1 more source

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation [PDF]

, 2012
Unresolved inflammation is associated with several widely occurring diseases such as arthritis, periodontal diseases, cancer, and atherosclerosis.
Recchiuti, Antonio, Serhan, Charles Nicholas   +1 more
core   +15 more sources

Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1

International Journal of Molecular Sciences, 2022
Specialized pro-resolving mediators (SPMs), including Maresins (MaR)-1 and 2, contribute to tear film homeostasis and resolve conjunctival inflammation. We investigated MaR2′s signaling pathways in goblet cells (GC) from rat conjunctiva. Agonist-induced [Ca2+]i and high-molecular weight glycoconjugate secretion were measured. MaR2 increased [Ca2+]i and
Markus V. Olsen, Anne V. Lyngstadaas, Jeffrey A. Bair, Robin R. Hodges, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +6 more
openaire   +2 more sources

Stereoselective Synthesis of Maresin-Like Lipid Mediators [PDF]

Synlett, 2019
14S,22-Dihydroxy-docosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (maresin-L1) and 14R,22-dihydroxy-docosa-4Z,7Z,10Z, 12E,16Z,19Z-hexaenoic acid (maresin-L2) were chemically synthesized. They were identical to activated macrophage-produced counterparts and their total synthesis was highly stereoselective, as revealed by chiral LC-UV-MS/MS analysis.
Song Hong, Yan Lu, Masao Morita, Shun Saito, Yuichi Kobayashi, Bokkyoo Jun, Nicolas Bazan, Xiaoming Xu, Yapin Wang   +8 more
openaire   +3 more sources

Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases [PDF]

, 2020
Prospective observational studies support the use of long-chain omega-3 polyunsaturated fatty acids (PUFAs) in the primary prevention of atherosclerotic cardiovascular disease; however, randomised controlled trials, have often reported neutral findings ...
Abdelhamid, Abdelhamid, Al-Hilal, Allayee, Armstrong, Aung, Baylin, Bhatt, Bjermo, Bosch, Bowman, Brown, Burdge, Burr, Cannon, Chavez, Cho, Chowdhury, Colazzo, Contreras, Cormier, Das, Dayton, de Toro-Martin, Demetz, Dorris, Draisma, Dumont, Dumont, Dupuis, Dwyer, Farvid, Fezeu, Floegel, Floegel, Forouhi, Frantz, Fretts, Fumagalli, Gabbs, Gammelmark, Gammelmark, Gillingham, Gol, Gromovsky, Guan, Hamley, Harris, Harris, Harris, Heemskerk, Hellstrand, Hilvo, Hooper, Hu, Illig, Imamura, Innes, Jakobsen, Jamieson, Johnson, Juan, Jäger, Jäger, Keaney, Kemp, Kromhout, Kröger, Kröger, Lankinen, Lemaitre, Leren, Li, Ligthart, Liu, Lu, Mahajan, Maki, Manson, Marklund, Marklund, McManus, Micha, Miettinen, Moltó-Puigmartí, Monk, Monteiro, Mozaffarian, Mozaffarian, Mozaffarian, Nelson, Nicholls, O'Neill, Pan, Piepoli, Powell, Ramsden, Ramsden, Ramsden, Ratnayake, Rimm, Risérus, Rizos, Roncaglioni, Rosqvist, Ross, Sarwar, Serhan, Simopoulos, Sioen, Siscovick, Skeaff, Skulas-Ray, Smith, Standl, Stephensen, Stoffel, Sudmant, Sun, Takkunen, Trumbo, Turpeinen, Wang, Wang, Wei, White, Willer, Woodhill, Wu, Wu, Wu, Xue, Yamagishi, Ye, Yokoyama, Yuan, Zhang   +136 more
core   +1 more source

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. [PDF]

, 2016
Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins.
Battistini, L, Chiurchiù, V, Dalli, J, Jacobsson, A, Leuti, A, Maccarrone, M, Serhan, CN   +6 more
core   +1 more source