Results 21 to 30 of about 4,269 (185)

Molecular pathobiology of scleritis and its therapeutic implications [PDF]

open access: yesInternational Journal of Ophthalmology, 2020
Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the former due to the failure of recognition of self.
Undurti N Das
doaj   +1 more source

Endogenous inhibitory mechanisms in asthma

open access: yesJournal of Allergy and Clinical Immunology: Global, 2023
Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E2, prostaglandin I2 ...
Sergio E. Chiarella, MD   +1 more
doaj   +1 more source

Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection

open access: yesFrontiers in Immunology, 2020
Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19).
Anandita Pal   +4 more
doaj   +1 more source

Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activation

open access: yesAntioxidants, 2020
Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis.
Gyeoung Jin Kang   +2 more
doaj   +1 more source

PCOS: A Chronic Disease That Fails to Produce Adequately Specialized Pro-Resolving Lipid Mediators (SPMs)

open access: yesBiomedicines, 2022
Introduction: Polycystic ovary syndrome (PCOS) is an endocrinological disorder that affects 5–15% of women of their reproductive age and is a frequent cause of infertility. Major symptoms include hyperandrogenism, ovulatory dysfunction, and often obesity
Pedro-Antonio Regidor   +6 more
doaj   +1 more source

Novel n-3 Immunoresolvents: Structures and Actions [PDF]

open access: yes, 2014
Resolution of inflammation is now held to be an active process where autacoids promote homeostasis. Using functional-metabololipidomics and in vivo systems, herein we report that endogenous n-3 docosapentaenoic (DPA) acid is converted during inflammation-
Colas, Romain A.   +2 more
core   +1 more source

Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA [PDF]

open access: yes, 2015
Omega-3 polyunsaturated fatty acids (PUFAs) exhibit neuroprotective properties and represent a potential treatment for a variety of neurodegenerative and neurological disorders.
Dyall, Simon
core   +2 more sources

Lipoxins as biomarkers of lupus and other inflammatory conditions

open access: yesLipids in Health and Disease, 2011
Inflammatory events persist in systemic lupus erythematosus (lupus) despite the use of anti-inflammatory (both steroidal and non-steroidal) and immunosuppressive drugs leading to delay in the healing/repair process and so tissue/organ damage continues ...
Das Undurti N
doaj   +1 more source

The Anti-Inflammatory Role of Omega-3 Polyunsaturated Fatty Acids Metabolites in Pre-Clinical Models of Psychiatric, Neurodegenerative, and Neurological Disorders

open access: yesFrontiers in Psychiatry, 2020
Inflammation has been identified as one of the main pathophysiological mechanisms underlying neuropsychiatric and neurodegenerative disorders. Despite the role of inflammation in those conditions, there is still a lack of effective anti-inflammatory ...
Juliette Giacobbe   +4 more
doaj   +1 more source

Cysteinyl Maresins Reprogram Macrophages to Protect Mice from Streptococcus pneumoniae after Influenza A Virus Infection

open access: yesmBio, 2022
Influenza A virus (IAV) infections are a leading cause of mortality worldwide. Excess mortality during IAV epidemics and pandemics is attributable to secondary bacterial infections, particularly pneumonia caused by Streptococcus pneumoniae.
Luciana P. Tavares   +9 more
doaj   +1 more source

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