Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions [PDF]
Journal of Experimental Medicine, 2008 The endogenous cellular and molecular mechanisms that control acute inflammation and its resolution are of wide interest. Using self-resolving inflammatory exudates and lipidomics, we have identified a new pathway involving biosynthesis of potent antiinflammatory and proresolving mediators from the essential fatty acid docosahexaenoic acid (DHA) by ...
Serhan, Charles N. +7 more
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Maresin 1 repletion improves muscle regeneration after volumetric muscle loss
eLife, 2023 The acute traumatic or surgical loss of skeletal muscle, known as volumetric muscle loss (VML), is a devastating type of injury that results in exacerbated and persistent inflammation followed by fibrosis. The mechanisms that mediate the magnitude and duration of the inflammatory response and ensuing fibrosis after VML remain understudied, and as such,
Jacqueline A Larouche +12 more
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Cysteinyl maresins regulate the prophlogistic lung actions of cysteinyl leukotrienes [PDF]
Journal of Allergy and Clinical Immunology, 2020 Cysteinyl leukotrienes (CysLTs) are potent prophlogistic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently effective treatment, suggesting additional regulatory mechanisms. Other cysteinyl-containing lipid mediators (LMs) derived from docosahexaenoic acid, namely maresin conjugates in tissue regeneration ...
Bruce D. Levy +7 more
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Maresin 1 resolves aged‐associated macrophage inflammation to improve bone regeneration [PDF]
The FASEB Journal, 2020 Abstract Inflammaging is associated with poor tissue regeneration observed in advanced age. Specifically, protracted inflammation after acute injury has been associated with decreased bone fracture healing and increased rates of nonunion in elderly patients.
Huang, Rong +3 more
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Lipid Mediators in Inflammation [PDF]
, 2016 Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (
Bennett, M, Gilroy, DW
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Administration of Maresin-1 ameliorates the physiopathology of experimental autoimmune encephalomyelitis [PDF]
Journal of Neuroinflammation, 2022 Abstract Background Resolution of inflammation is an active and regulated process that leads to the clearance of cell debris and immune cells from the challenged tissue, facilitating the recovery of homeostasis. This physiological response is coordinated by endogenous bioactive lipids known as specialized pro-resolving ...
Sánchez Fernández, Alba +6 more
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Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review
Journal of Advanced Research, 2018 Ageing is inevitable. Recent studies suggest that it could be delayed. Low-grade systemic inflammation is seen in type 2 diabetes mellitus, hypertension and endothelial dysfunction that are common with increasing age.
Undurti N. Das
doaj +1 more source
Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid [PDF]
, 2015 postprin
Cristol, JP +14 more
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Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues
Future Medicinal Chemistry, 2022 Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Kevin Daly +2 more
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Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust [PDF]
, 2013 BACKGROUND: Exposure to organic dust causes detrimental airway inflammation. Current preventative and therapeutic measures do not adequately treat resulting disease, necessitating novel therapeutic interventions.
Art J Heires +6 more
core +2 more sources