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Marker Test of Poliovirus in Relation to Mass Vaccination with Live Oral Vaccines
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The use of marker vaccines in eradication of herpesviruses
Journal of Biotechnology, 1996Marker vaccines are vaccines that allow serological differentiation between infected and vaccinated individuals. This differentiation is based on the absence of one or more microbial proteins in the vaccine that are present in the wild-type micro-organism.
J T van Oirschot +2 more
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Marker vaccine strategies and candidate CSFV marker vaccines
Vaccine, 2007Classical swine fever (CSF) is an economically important highly contagious disease of swine worldwide. Classical swine fever virus (CSFV) is its etiological agent, and the only natural hosts are domestic pigs and wild boars. Although field CSFV strains vary in the virulence, they all result in serious losses in pig industry.
Xiao-Nan Dong, Ying-Hua Chen
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Novel marker vaccines against classical swine fever
Vaccine, 2007Classical swine fever (CSF) is one of the most devastating epizootic diseases of pigs worldwide. For eradication and control purposes, CSF vaccination is an important tool, and efficacious and safe attenuated vaccines have been available for many decades (for example, the C-strain vaccines).
Bernd Hoffmann +2 more
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Experiences with two BHV1 marker vaccines
Both marker vaccines tested were deleted vaccines, one had a gG, the other a gE deletion. The gG deleted vaccine was inactivated the gE deleted vaccine had a live and an inactivated form. The object of the trial was to evaluate these vaccines in heifers and calves. Twenty young heifers were used for the inactivated deleted vaccines and 16 four week old
Straub, O. C.
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Predictive markers of safety and immunogenicity of adjuvanted vaccines
Biologicals, 2013Vaccination represents one of the greatest public health triumphs; in part due to the effect of adjuvants that have been included in vaccine preparations to boost the immune responses through different mechanisms. Although a variety of novel adjuvants have been under development, only a limited number have been approved by regulatory authorities for ...
Mastelic B +6 more
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Veterinary Microbiology, 1996
A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle.
Bosch, J.C. +3 more
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A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle.
Bosch, J.C. +3 more
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1978
Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
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Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
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Tumor Antigens as Surrogate Markers and Targets for Therapy and Vaccines
2006There are a large number of tumor antigens, which may either be specific to the tumor or inappropriately expressed or processed (tumor-associated antigen, TAA). Over the last few years, hundreds of new TAAs have been identified. Some of these represent good targets for both passive (antibody based) and active (vaccine based) therapies.
Dalgleish, A, Pandha, H
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Biochemical and Biophysical Research Communications, 2008
Using plasmid-based reverse genetics, we generated a molecularly altered virus, H5N1/PR8-5B19, containing modified HA and NA genes from A/Goose/Guangdong/1/96 (GS/GD/1/96). In the H5N1/PR8-5B19 virus, the HA cleavage site was modified to resemble that of low-pathogenic avian strains and a portion of the NA stalk region was replaced by the ...
Chengjun, Li +9 more
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Using plasmid-based reverse genetics, we generated a molecularly altered virus, H5N1/PR8-5B19, containing modified HA and NA genes from A/Goose/Guangdong/1/96 (GS/GD/1/96). In the H5N1/PR8-5B19 virus, the HA cleavage site was modified to resemble that of low-pathogenic avian strains and a portion of the NA stalk region was replaced by the ...
Chengjun, Li +9 more
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