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Vaccine, 1997 A comparative study was carried out to evaluate the efficacy of three bovine herpesvirus 1 (BHV1) marker vaccines to reduce the reexcretion of virus after reactivation of latent BHV1. A live gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested in three identical experiments in which cattle, latently
M J Kaashoek, J T Van Oirschot
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The use of marker vaccines in eradication of herpesviruses
Journal of Biotechnology, 1996Marker vaccines are vaccines that allow serological differentiation between infected and vaccinated individuals. This differentiation is based on the absence of one or more microbial proteins in the vaccine that are present in the wild-type micro-organism.
J T Van Oirschot +2 more
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Marker vaccine strategies and candidate CSFV marker vaccines
Vaccine, 2007Classical swine fever (CSF) is an economically important highly contagious disease of swine worldwide. Classical swine fever virus (CSFV) is its etiological agent, and the only natural hosts are domestic pigs and wild boars. Although field CSFV strains vary in the virulence, they all result in serious losses in pig industry.
Xiao-Nan Dong, Ying-Hua Chen
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Novel marker vaccines against classical swine fever
Vaccine, 2007Classical swine fever (CSF) is one of the most devastating epizootic diseases of pigs worldwide. For eradication and control purposes, CSF vaccination is an important tool, and efficacious and safe attenuated vaccines have been available for many decades (for example, the C-strain vaccines).
Martin Beer +2 more
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Veterinary Microbiology, 1996
A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle.
M J Kaashoek, J T Van Oirschot
exaly +4 more sources
A comparative study on the efficacy of 3 bovine herpesvirus 1 (BHV1) marker vaccines was carried out. An attenuated gE-negative vaccine, an inactivated gE-negative vaccine and an experimental gD-subunit vaccine were tested twice in a vaccination-challenge experiment in cattle.
M J Kaashoek, J T Van Oirschot
exaly +4 more sources
Marker vaccines and the impact of their use on diagnosis and prophylactic measures.
Revue scientifique et technique (International Office of Epizootics), 2007 Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of their use on the diagnosis and prevention of major infectious diseases.
Vannier, P. +7 more
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Predictive markers of safety and immunogenicity of adjuvanted vaccines
Biologicals, 2013Vaccination represents one of the greatest public health triumphs; in part due to the effect of adjuvants that have been included in vaccine preparations to boost the immune responses through different mechanisms. Although a variety of novel adjuvants have been under development, only a limited number have been approved by regulatory authorities for ...
Mastelic B +6 more
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Veterinary Quarterly, 2000 Detection of classical swine fever virus (CSFV) can be achieved by a range of assays of which the most commonly used are: immunohistochemical and virus culture techniques.
A J De Smit
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Biochemical and Biophysical Research Communications, 2008
Using plasmid-based reverse genetics, we generated a molecularly altered virus, H5N1/PR8-5B19, containing modified HA and NA genes from A/Goose/Guangdong/1/96 (GS/GD/1/96). In the H5N1/PR8-5B19 virus, the HA cleavage site was modified to resemble that of low-pathogenic avian strains and a portion of the NA stalk region was replaced by the ...
Chengjun, Li +9 more
openaire +2 more sources
Using plasmid-based reverse genetics, we generated a molecularly altered virus, H5N1/PR8-5B19, containing modified HA and NA genes from A/Goose/Guangdong/1/96 (GS/GD/1/96). In the H5N1/PR8-5B19 virus, the HA cleavage site was modified to resemble that of low-pathogenic avian strains and a portion of the NA stalk region was replaced by the ...
Chengjun, Li +9 more
openaire +2 more sources
1978
Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
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Publisher Summary This chapter is concerned with virus vaccines and their genetically conditioned markers. For many years, virus vaccines have been in fact the only effective means for reducing the morbidity of virus infections, and thus far biogenic, semisynthetic, and synthetic antiviral substances have failed to give satisfactory results. Although
openaire +2 more sources