Results 251 to 260 of about 45,660 (287)

The mas oncogene encodes an angiotensin receptor

Nature, 1988
The class of receptors coupled to GTP-binding proteins share a conserved structural motif which is described as a 'seven-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. Identified examples include the mammalian opsins, alpha 1-, alpha 2-, beta 1- and beta 2-adrenergic receptors, the ...
T R, Jackson, L A, Blair, J, Marshall, M, Goedert, M R, Hanley   +4 more
openaire   +2 more sources

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

Clinical Science, 2014
The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin–angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists
Villela, Daniel, Leonhardt, Julia, Patel, Neal, Joseph, Jason, Kirsch, Sebastian, Hallberg, Anders, Unger, Thomas, Bader, Michael, Santos, Robson A, Sumners, Colin, Steckelings, Ulrike Muscha   +10 more
openaire   +4 more sources

The cardiac expression of Mas receptor is responsive to different physiological and pathological stimuli

Peptides, 2012
The Mas protooncogene encodes a G protein-coupled receptor that has been described as a functional receptor for the cardioprotective fragment of the renin-angiotensin system (RAS), Angiotensin (Ang)-(1-7).
Marco Fabricio Dias-Peixoto, Dirceu Sousa Melo, Maria JOSÉ Campagnole-Santos   +2 more
exaly   +2 more sources

Participation of AT1 and Mas receptors in the modulation of inflammatory pain

Peptides, 2014
We investigated the mechanisms underlying the endogenous control of nociception at the peripheral level during inflammation. We hypothesized that angiotensin receptors could modulate pain at the peripheral level via endogenous processes because angiotensin receptors are present in peripheral nerve terminals.
Aline C O, Costa, Thiago R L, Romero, Daniela F, Pacheco, Andrea C, Perez, Atila, Savernini, Robson R A, Santos, Igor D G, Duarte   +6 more
openaire   +2 more sources

Mas receptor contributes to pregnancy-induced cardiac remodelling

Clinical Science, 2016
Previous studies have demonstrated a protective effect of the Ang-(1–7)/Mas receptor axis on pathological cardiac hypertrophy. Also, the involvement of Mas receptor in exercise-induced cardiac hypertrophy has been suggested. However, the role of the Ang-(1–7)/Mas receptor on pregnancy-induced cardiac remodelling remains unknown.
Cintia, do Carmo E Silva, Jônathas Fernandes Queiroz, de Almeida, Larissa Matuda, Macedo, Marcos Barrouin, Melo, Gustavo Rodrigues, Pedrino, Fernanda Cristina Alcantara, Dos Santos, Manoel Francisco, Biancardi, Robson Augusto Souza, Dos Santos, Adryano Augustto Valladão, de Carvalho, Elizabeth Pereira, Mendes, Diego Basile, Colugnati, Renata, Mazaro-Costa, Carlos Henrique, de Castro   +12 more
openaire   +2 more sources

Expression of the Mas receptor is upregulated in skeletal muscle wasting

Histochemistry and Cell Biology, 2014
Skeletal muscle atrophy during sepsis, immobilization, and chronic diseases is characterized by an increase in expression and activity of the muscle-specific ubiquitin 3 ligases atrogin-1 and MuRF-1. The classical renin-angiotensin system (RAS), by high level of circulating angiotensin II (AngII) is directly involved in skeletal muscle wasting ...
María Gabriela, Morales, Johanna, Abrigo, Carla, Meneses, Franco, Cisternas, Felipe, Simon, Claudio, Cabello-Verrugio   +5 more
openaire   +2 more sources

Mas Receptor Agonists as Novel Antihypertensive Agents

Current Hypertension Reviews, 2012
It is well known that the renin-angiotensin system (RAS) plays a pivotal role in the control of the cardiovascular and renal systems and in the pathogenesis of cardiovascular and renal diseases. The classical concept of the RAS has been changed in the recent years by the inclusion of novels components. Among the novel components of the RAS, Angiotensin(
Silvia Quintao Savergnini, Rodrigo Araujo Fraga-Silva, Anderson Jose Ferreira, Robson Augusto Souza dos Santos   +3 more
openaire   +1 more source

Pharmacology and Signaling of MAS-Related G Protein–Coupled Receptors

Pharmacological Reviews, 2014
Signaling by heptahelical G protein-coupled receptors (GPCR) regulates many vital body functions. Consequently, dysfunction of GPCR signaling leads to pathologic states, and approximately 30% of all modern clinical drugs target GPCR. One decade ago, an entire new GPCR family was discovered, which was recently named MAS-related G protein-coupled ...
Hans Jürgen, Solinski, Thomas, Gudermann, Andreas, Breit   +2 more
openaire   +2 more sources

Characterization and regulation of prolactin receptors in MA-10 Leydig cells

Molecular and Cellular Endocrinology, 1998
The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. Two forms of PRL-R, a high and a low molecular weight form, were revealed by studies of covalent crosslinking of 125I-human GH to cultured MA ...
E, Weiss-Messer, R, Ber, T, Amit, R J, Barkey   +3 more
openaire   +2 more sources

Mas and Its Related G Protein–Coupled Receptors, Mrgprs

Pharmacological Reviews, 2014
The Mas-related G protein-coupled receptors (Mrgprs or Mas-related genes) comprise a subfamily of receptors named after the first discovered member, Mas. For most Mrgprs, pruriception seems to be the major function based on the following observations: 1) they are relatively promiscuous in their ligand specificity with best affinities for itch-inducing ...
Michael, Bader, Natalia, Alenina, Miguel A, Andrade-Navarro, Robson A, Santos   +3 more
openaire   +2 more sources