Results 261 to 270 of about 45,660 (287)

20-Hydroxyecdysone activates the protective arm of the RAAS via the MAS receptor

Journal of Molecular Endocrinology, 2022
20-Hydroxyecdysone (20E) is a steroid hormone that plays a key role in insect development through nuclear ecdysteroid receptors (EcR/RXR complex) and at least one membrane GPCR receptor (DopEcR). It also displays numerous pharmacological effects in mammals, where its mechanism of action is still debated, involving either an unidentified GPCR or the ...
René Lafont, Maria Serova, Blaise Didry-Barca, Sophie Raynal, Louis Guibout, Laurence Dinan, Stanislas Veillet, Mathilde Latil, Waly Dioh, Pierre J Dilda   +9 more
openaire   +2 more sources

Mas receptors in modulating relaxation induced by perivascular adipose tissue

Life Sciences, 2011
Perivascular adipose tissue (PVAT) is known to secrete vascular relaxation factors, and angiotensin 1-7 [Ang-(1-7)] acting on the endothelium is one of the endothelium-dependent relaxation factors. Mas protein is the receptor for Ang-(1-7). Using aorta from Mas-knockout (K/O) and wild type (FVB) mice, we wished to establish the essential role of Mas ...
Robert M K W, Lee, Michael, Bader, Natalia, Alenina, Robson A S, Santos, Yu-Jing, Gao, Chao, Lu   +5 more
openaire   +2 more sources

Abstract 464: Molecular and Functional Interaction of the Angiotensin AT2-Receptor and the Receptor MAS

Hypertension, 2013
The angiotensin AT2-receptor (AT2R) and the receptor MAS both mediate very similar tissue-protective actions. Furthermore, AT2R-antagonists have been reported to block effects of the MAS-agonist Ang 1-7. Therefore we speculated that a molecular association between these two receptors exists resulting in functional interactions.
Daniel Villela, Julia Leonhardt, Lisa M Muenter, Kristin Lucht, Verena Benz, Pawel Namsolleck, Natalia Alenina, Thomas Unger, Michael Bader, Robson A Santos, Ulrike M Steckelings   +10 more
openaire   +1 more source

Mas receptor blockade impairs exercise-induced cardiac hypertrophy

Peptides
Exercise training leads to physiological cardiac hypertrophy and the protective axis of the renin-angiotensin system composed of angiotensin-converting enzyme 2, angiotensin-(1-7), and Mas receptor seems involved in this process. However, the role of the basal activity of the Mas receptor in exercise-induced physiological cardiac hypertrophy is still ...
Christoffer Novais de Farias, Silva, Amanda de Sá Martins de, Bessa, Jaqueline Moura da, Costa, Paulo Ricardo, Lopes, Ângela Ribeiro, Neves, Monique Machado Louredo, Teles Bombardelli, Diego Basile, Colugnati, Gustavo Rodrigues, Pedrino, Elizabeth Pereira, Mendes, Robson Augusto Sousa Dos, Santos, Manoel Francisco, Biancardi, Fernanda Cristina Alcantara Dos, Santos, Carlos Henrique, Castro   +12 more
openaire   +2 more sources

Abstract P318: Signaling Pathways Triggered by the Mas Receptor

Hypertension, 2017
Mas receptor (MasR) is a class A Orphan G-protein-coupled receptor (GPCR). Although angiotensin-(1-7) [Ang-(1-7)] has been reported as its putative ligand, the intracellular signaling pathways activated by the MasR remain only partially characterized.
Valeria Burghi, Emiliana B Echeverria, Diego T Quiroga, Marina C Munoz, Natalia C Fernandez, Fernando P Dominici   +5 more
openaire   +1 more source

The role of Mas receptors in an experimental rat glaucoma model

Acta Ophthalmologica, 2011
AbstractPurpose To evaluate the neuroprotective and/or oculohypotensive effects of potent angiotensin system agents known to reduce intraocular pressure in the normotensive rabbits by using an experimental laser‐induced glaucoma model in rat eye.Methods Experimental glaucoma was induced unilaterally using laser photocoagulation of the episcleral and ...
A VAAJANEN, G KALESNYKAS, H VAPAATALO, H UUSITALO   +3 more
openaire   +1 more source

Immunohistochemical localization of the angiotensin-(1–7) receptor Mas in the murine forebrain

Cell and Tissue Research, 2012
Apart from the well-known biologically active angiotensin II, other biologically active angiotensins have been discovered, including angiotensin IV and angiotensin-(1-7). Some years ago, we and others discovered that the Mas proto-oncogene encodes a receptor that is essential for angiotensin-(1-7) signaling.
M, Freund, T, Walther, O, von Bohlen und Halbach   +2 more
openaire   +2 more sources

Mas Receptor

2015
Robson Augusto Souza dos Santos, Walkyria Oliveira Sampaio   +1 more
openaire   +1 more source

The Multifaceted Mas-Related G Protein-Coupled Receptor Member X2 in Allergic Diseases and Beyond

International Journal of Molecular Sciences, 2021
Paola Leonor Quan, Marina Sabaté-Brescó, Yanru Guo   +2 more
exaly  

Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor

Metabolism: Clinical and Experimental, 2020
Ariana Vargas-Castillo, Ivan Torre-Villalvazo, Alejandro Schcolnik–Cabrera   +2 more
exaly