Results 41 to 50 of about 357,348 (338)

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch [PDF]

Journal of Investigative Dermatology, 2018
Cowhage is routinely used in human studies of histamine-independent itch. As such, it is of interest to understand its mechanism of action. The active component of cowhage is a cysteine protease called mucunain. As serine proteases can activate members of the protease-activated receptor (PAR) family to induce itch and pain, the mechanism of action of ...
Vemuri B, Reddy, Ehsan, Azimi, Lei, Chu, Ethan A, Lerner   +3 more
openaire   +2 more sources

Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells

Pharmacology Research & Perspectives, 2020
Angiotensin‐(1‐7), an endogenous agonist for the MasR, has been shown to interact with ang‐II AT1R and AT2R. Earlier we showed a physical and functional interaction between MasR and AT2R in response to their respective agonists ang‐(1‐7) and C21 ...
Sanket Patel, Tahir Hussain
doaj   +1 more source

A novel mechanism of action for angiotensin-(1-7) via the angiotensin type 1 receptor [PDF]

, 2016
No abstract ...
Nicklin, Stuart A.
core   +1 more source

Increased vascular sympathetic modulation in mice with Mas receptor deficiency [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2016
Introduction: The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1–7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk and provide information about the autonomic modulation of the cardiovascular system.
Casali, Karina Rabello UNIFESP, Dartora, Daniela Ravizzoni, Moura, Marina, Bertagnolli, Mariane, Bader, Michael UNIFESP, Haibara, Andrea, Alenina, Natalia, Irigoyen, Maria Claudia UNIFESP, Santos, Robson A.   +8 more
openaire   +4 more sources

Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

Endocrine Regulations, 2016
Adipose tissue expresses all the renin-angiotensin system (RAS) components that play an important role in the adipogenesis, lipid and glucose metabolism regulation in an auto/paracrine manner.
Slamkova M, Zorad S, Krskova K
doaj   +1 more source

TO90 inhibits angiotensin II-induced inflammatory response by up-regulating ACE2/Ang-(1-7)/MAS receptor axis in human retinal pigment epithelial cells

Di-san junyi daxue xuebao, 2019
Objective To investigate whether TO90 inhibits angiotensin II (Ang Ⅱ)-induced inflammatory response by regulating the expressions of ACE2/Ang-(1-7)/MAS receptor axis in human retinal pigment epithelial cells.
MAI Yuxin, WANG Luoziyi, YU Peng, LIU Yanyao, LEI Bo   +4 more
doaj   +1 more source

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]

, 2013
Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit, A Romero, A Serrano, A Strasser, AA Genazzani, AJ Shaywitz, Andreas Breit, AS Kirshenbaum, B Fioravanti, B Knoll, B Zimmerman, BD Hudson, C Abbadie, C Gaudioso, CH Wang, DA Taylor, DB Wainscott, E Bullitt, E Grazzini, E Utreras, EJ Vallender, ES Burstein, F Jow, FA White, FA White, Franziska Petermann, G Buchwalter, G Kendall, GA Jamieson Jr, H Chen, H Jung, H Jung, H Subramanian, Hans Jürgen Solinski, HB McIlvain, HJ Solinski, Ingrid Boekhoff, J Li, JG Jackson, JH Sun, JJ Moore Jr, K Rothe, K Tatemoto, Kathrin Rothe, KL Pierce, L Hao, L Jenkins, LM Boland, M Brinkmann, N Eijkelkamp, N Katayama, N Kerr, OM Andrisani, P Kunapuli, P Sikand, PC Francel, PM Lembo, PS Puttfarcken, R Maldonado, RD Groth, RD Groth, RJ Davis, Roland Seifert, S Bhangoo, S Dolan, SF Fan, SK Bhangoo, SN Fatakia, SW Ko, Thomas Gudermann, V Baubet, VS Seybold, X Dong, Y Li   +73 more
core   +3 more sources

Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat

Endocrine Regulations, 2019
Objective. Epidemiological studies confirm that hypertensive patients respond differently to renin-angiotensin system (RAS) inhibition depending on their gender.
Pidikova Paulina, Svitok Pavel, Herichova Iveta   +2 more
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source