Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis [PDF]
, 2014 Cassette dosing of compounds for preclinical drug plasma pharmacokinetic analysis has been shown to be a powerful strategy within the pharmaceutical industry for increasing throughput while decreasing the number of animals used.
Andren, Per E. +10 more
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A Mass Spectrometry Primer for Mass Spectrometry Imaging [PDF]
, 2010 Mass spectrometry imaging (MSI), a rapidly growing subfield of chemical imaging, employs mass spectrometry (MS) technologies to create single- and multi-dimensional localization maps for a variety of atoms and molecules. Complimentary to other imaging approaches, MSI provides high chemical specificity and broad analyte coverage.
Stanislav S, Rubakhin +1 more
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Mass spectrometry imaging of 3D tissue models [PDF]
, 2018 A 3D cell culture is an artificially created environment in which cells are permitted to grow/interact with their surroundings in all three dimensions.
Clench, Malcolm +3 more
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Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level. [PDF]
, 2018 ‘A picture is worth a thousand words’ is an idiom from the English language (‘borrowed’ from on old Chinese proverb) that conveys the notion that a complex idea can be succinctly and fully described by a single image. Never has this expression been truer
Andrén, PE +11 more
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Enzymatic transhalogenation of dendritic RGD peptide constructs with the fluorinase [PDF]
, 2016 We thank EPSRC and the Scottish Imaging Network (SINAPSE) for grants. DO’H thanks the Royal Society for a Wolfson Research Merit Award and ST is grateful to the John and Kathleen Watson Scholarship for financial support.
Fleming, Ian N. +2 more
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Rapid deconvolution of low-resolution time-of-flight data using Bayesian inference [PDF]
, 2019 The deconvolution of low-resolution time-of-flight data has numerous advantages, including the ability to extract additional information from the experimental data.
Bernardo J. M. +7 more
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A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife [PDF]
, 2016 Background: This pilot study assessed the diagnostic accuracy of rapid evaporative ionization mass spectrometry (REIMS) in colorectal cancer (CRC) and colonic adenomas. Methods: Patients undergoing elective surgical resection for CRC were recruited at St.
Alexander, J +17 more
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Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]
, 2014 BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A +3 more
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Introduction of 4-chloro-alpha-cyanocinnamic acid liquid matrices for high sensitivity UV-MALDI MS [PDF]
, 2010 Matrix-assisted laser desorption/ionization (MALDI) is a key ionization technique in mass spectrometry (MS) for the analysis of labile macromolecules.
Cramer, Rainer +2 more
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Mass Spectrometry Imaging of Biomaterials
Materials, 2023 The science related to biomaterials and tissue engineering accounts for a growing part of our knowledge. Surface modifications of biomaterials, their performance in vitro, and the interaction between them and surrounding tissues are gaining more and more attention. It is because we are interested in finding sophisticated materials that help us to treat
Paulina Kret +5 more
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