Results 151 to 160 of about 10,829,007 (362)

IL-10 in Mast Cell-Mediated Immune Responses: Anti-Inflammatory and Proinflammatory Roles [PDF]

, 2021
Kazuki Nagata, Chiharu Nishiyama
openalex   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Relationship between mast cell density and various histological features in melanocytic lesions [PDF]

Blagjica Lazarova, Gordana Petrushevska, Dzengis Jashar, Zdenka Stojanovska   +3 more
openalex   +1 more source

The mode of inhibition of the Na⁺‐K⁺ pump activity in mast cells by calcium [PDF]

, 1989
Torben Knudsen, Torben Johansen
openalex   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Vectorial Exposure and Fusion Of Secretory Granule Content At The Mast Cell Degranulatory Synapse [PDF]

, 2014
Nicolas Gaudenzio, Régis Joulia, Salvatore Valitutti, Éric Espinosa   +3 more
openalex   +1 more source

Dnmt3a restrains mast cell inflammatory responses

Proceedings of the National Academy of Sciences of the United States of America, 2017
Cristina Leoni, Sara Montagner, A. Rinaldi, F. Bertoni, S. Polletti, C. Balestrieri, S. Monticelli   +6 more
semanticscholar   +1 more source

A Review on Quantitative Process Analytical Technology for Continuous Downstream Processing of Monoclonal Antibodies

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho, Ana Cruz, Cees Haringa, Marcel Ottens, Marieke Klijn   +4 more
wiley   +1 more source

Mast cell sarcoma with concurrent mast cell leukaemia [PDF]

British Journal of Haematology, 2020
Lauren M. Raymond, Tracy Funk, Rita M. Braziel, Guang Fan, Ken Gatter, Marc Loriaux, Jennifer Dunlap, Philipp W. Raess   +7 more
openaire   +2 more sources