Magnifying Glass on Sinonasal NUT Carcinoma Heterogeneity via Spatial Transcriptomics
ABSTRACT Background Nuclear protein in testis (NUT) carcinomas (NCs) are rare, clinically aggressive tumors with characteristic translocation involving NUTM1 and BRD4 genes. While NCs are generally characterized by undifferentiated basaloid cells with focal/abrupt squamous differentiation, tumoral heterogeneity remains unexplored.
Diana Bell+8 more
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Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications. [PDF]
Qiao T+5 more
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Vitamin A and the biosynthesis of sulphated mucopolysaccharides. Experiments with rats and cultured neoplastic mast cells [PDF]
D. B. Thomas, C. A. Pasternak
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The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance
Yapeng Li+3 more
semanticscholar +1 more source
A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Li Zhou+15 more
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Cashew nut oligopeptide inhibits mast cell degranulation by suppressing activation of the NF-Κb signalling pathway. [PDF]
Chen D, Zhou X, Zhang Y, Chen J.
europepmc +1 more source
The localization of3H-corticosterone in mast cell granules by electron microscopic autoradiography [PDF]
G Csaba+3 more
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This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou+19 more
wiley +1 more source
A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis. [PDF]
Kothari R+21 more
europepmc +1 more source