Results 221 to 230 of about 10,756,993 (383)

Magnifying Glass on Sinonasal NUT Carcinoma Heterogeneity via Spatial Transcriptomics

open access: yesHead &Neck, EarlyView.
ABSTRACT Background Nuclear protein in testis (NUT) carcinomas (NCs) are rare, clinically aggressive tumors with characteristic translocation involving NUTM1 and BRD4 genes. While NCs are generally characterized by undifferentiated basaloid cells with focal/abrupt squamous differentiation, tumoral heterogeneity remains unexplored.
Diana Bell   +8 more
wiley   +1 more source

Single‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression

open access: yesiMeta, EarlyView.
A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Li Zhou   +15 more
wiley   +1 more source

RRM2‐targeted nanocarrier enhances radiofrequency ablation efficacy in hepatocellular carcinoma through ferroptosis amplification and immune remodeling

open access: yesiMeta, EarlyView.
This study proposes an innovative therapeutic approach by combining RRM2 gene knockout with a nanocarrier system, significantly enhancing the efficacy of radiofrequency ablation for hepatocellular carcinoma. The study developed a tumor microenvironment‐responsive nanosystem that achieves synergistic effects through SPIO‐mediated and RRM2 knockout ...
Weiliang Hou   +19 more
wiley   +1 more source

A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis. [PDF]

open access: yesCell
Kothari R   +21 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy