Results 1 to 10 of about 9,281 (250)

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives

Molecules, 2023
Matrine is a quinoline alkaloid extracted and separated from the dried root, fruit, and other parts of the plant Sophora flavescens using an organic solvent.
Jinlei Li, Shijie Wei, Davies Marabada, Zhizhong Wang, Qing Huang   +4 more
doaj   +4 more sources

Matrine alkaloids modulating DNA damage repair in chemoresistant non-small cell lung cancer cells [PDF]

BMC Cancer
Background Non-small cell lung cancer (NSCLC) presents a significant challenge in the medical field due to its high incidence and resistance to chemotherapy. Chemoresistance in NSCLC diminishes treatment efficacy and contributes to poor patient outcomes.
Fengping Wang, Jun Liu, Wenliang Liao, Lixiang Zheng, Shuai Qian, Lisi Mao   +5 more
doaj   +3 more sources

Safety evaluation of matrine and its impact as a feed additive on the production performance of piglets [PDF]

Frontiers in Veterinary Science
IntroductionPrevious studies have suggested that matrine may improve animal production performance, but its role and underlying mechanisms remain unclear.MethodsFollowing the determination of the LD50 of matrine in ICR mice, the long-term toxic effects ...
Zhigang Cao, Yalin Wu, Xiangming Cong, Abdul Haseeb, Panpan Sun, Hua Zhang, Kuohai Fan, Wei Yin, Huizhen Yang, Zhenbiao Zhang, Jia Zhong, Jianzhong Wang, Yaogui Sun, Hongquan Li, Na Sun   +14 more
doaj   +2 more sources

Natural Matrine-Integrated Pollen Delivery Systems for Allergic Contact Dermatitis Treatment. [PDF]

Smart Med
Allergic contact dermatitis (ACD) is an inflammatory dermatitis with a high morbidity and recurrence rate. Scientific attention is focused on the development of safe and comfortable therapeutics of ACD.
Wang Y, Cai L, Zhang Y, Cong Y, Zhao Y.
europepmc   +2 more sources

Matrine Restores Colistin Efficacy Against <i>mcr-1</i>-Carrying <i>Escherichia coli</i>. [PDF]

Molecules
The emergence of mcr-1-mediated colistin resistance has become a critical global health concern, highlighting the urgent need for innovative approaches to restore colistin’s therapeutic potential. In this study, we evaluated the antibacterial activity of
Wang Z, Li X, Zhao L, Liu S, Du J, Jia X, Ge L, Xu J, Cui K, Ga Y, Wang J, Xia X.   +11 more
europepmc   +2 more sources

The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway

Frontiers in Oncology
BackgroundMatrine is an alkaloid extracted from Sophorus beans of the legume family, and it has significant effects and a variety of pharmacological activities. Osteosarcoma(OS) is a common malignant bone tumor that is characterized by high incidence and
Xincheng Huang, Jun Zeng, Siyuan Ruan, Zhuolin Lei, Jingyuan Zhang, Hong Cao   +5 more
doaj   +2 more sources

Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression. [PDF]

World J Gastrointest Oncol
BACKGROUND The 5-year survival rate of patients with colorectal cancer (CRC) in China is only 56.9%, highlighting the need for new therapeutic drugs. Previous studies have shown that matrine exhibits antitumor effects by inducing apoptosis.
Zhou YC, Wang QQ, Zhou GY, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK.   +8 more
europepmc   +2 more sources

Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model. [PDF]

Front Microbiol
Introduction Porcine circovirus type 2 (PCV2) is an important pathogen that causes diarrhea in nursery and fattening pigs, resulting in huge economic losses for commercial pig farms.
Wang H, Sun N, Sun P, Zhang H, Yin W, Zheng X, Fan K, Sun Y, Li H.   +8 more
europepmc   +2 more sources

Involvement of ionomic metabolism of both the cerebrospinal fluid and the spinal cord in the analgesic efficacy of matrine in rats [PDF]

Pharmaceutical Biology
Context Matrine has antinociceptive properties, and spinal cord ionomic changes are involved in bone cancer pain.Objective To investigate the relationship between ionomic metabolism in cerebrospinal fluid (CSF) and spinal cord and matrine’s analgesic ...
Jin-Lu Huang, Chen-Yue Tang, Yao Fu, Li-Li Wan, Jie Li, Xi-Peng Sun, Jia-Lu Hu, Yue-Yi Zhang, Li-Ying Qu, Miao-Jia Fu, Yuan-Yuan Zhang, Le Ma, Cheng Guo, Jiu-Geng Chen   +13 more
doaj   +2 more sources

Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli [PDF]

Poultry Science
Avian pathogenic Escherichia coli (APEC) is a major cause of avian colibacillosis. Matrine, a natural component derived from Sophora flavescens, exhibits various pharmacological effects, including anti-inflammatory and antioxidant activities.
Ningning Mao, Yaming Yu, Jiqin Cui, Jin He, Yang Yang, Deyun Wang   +5 more
doaj   +2 more sources