Results 11 to 20 of about 9,281 (250)

Research Advances on Matrine

Frontiers in Chemistry, 2022
Matrine is an alkaloid extracted from traditional Chinese herbs including Sophora flavescentis, Sophora alopecuroides, Sophora root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs.
Xiaoying Sun, Li Jia, Zheng Rong, Xin Zhou, Luan Cao, A. Li, Meng Guo, Jie-Kai Jin, Yin-Di Wang, Ling Huang, Yi-Heng Li, Zhongguo He, Long Li, Ruifeng Ma, Yingtao Lv, Keping Shao, Juan Zhang, H. Cao   +17 more
semanticscholar   +4 more sources

Matrine nanoparticles improve functional constipation and associated depressive behavioral disorders by modulating the gut-brain axis

European Cells & Materials
Background: Functional constipation (FC) in the elderly is associated with depressive behavior. Matrine is a bioactive alkaloid with anti-inflammatory properties, promoting intestinal motility and gut barrier function. This study aimed to investigate how
J Liu, SK Mu, JX Gao, XY Yan
doaj   +2 more sources

Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways

Cell Death and Disease, 2021
Studies have shown that matrine has antitumor activity against many types of cancers. However, the direct target in cancer cells of its anticancer effect has not been identified.
Xi Zhang, Hui Xu, Xiaoyang Bi, Guoqing Hou, Andong Liu, Youyun Zhao, Guoping Wang, Xuan Cao   +7 more
doaj   +1 more source

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine. [PDF]

Cancer Med
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Tian Y, Ni B, Cai D, Wang J, Zhou J, Song M, Zhang X, Jiang J.   +7 more
europepmc   +2 more sources

Total Synthesis of Matrine Alkaloids

Journal of the American Chemical Society, 2022
The total synthesis of three diastereomeric matrine natural products is reported. The eight-step synthesis commences with simple acyclic precursors, forms all four rings of the tetracyclic natural product framework and forges ten of the twenty covalent bonds of the target structure.
Nicholas L. Magann, Erin Westley, Madison J. Sowden, Michael G. Gardiner, Michael S. Sherburn   +4 more
openaire   +2 more sources

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Frontiers in Pharmacology, 2022
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens, has a good anti-leukemia effect, but its key target and mechanism remains unclear.
Wang-Jing Zhong, Lingdi Ma, Lingdi Ma, Fanfan Yang, Jialin Cao, Junyu Tan, Bohong Li   +6 more
doaj   +1 more source

Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]

, 2014
published_or_final_versio
CHEUNG, F, Feng, Y, Kobayashi, S, Li, C, TAN, HY, Wang, N, Wang, X, Zhong, S   +7 more
core   +6 more sources

Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway

BMC Complementary Medicine and Therapies, 2021
Background C-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from Sophora flavescens Ait.
Jianyou Gu, Xiao Wang, Ling Zhang, Jingjing Xiang, Jingya Li, Zheng Chen, Yu Zhang, Junfa Chen, Jianping Shen   +8 more
doaj   +1 more source

Molecular Rotation Spectrum of Tetracyclic Quinolizidines: Observation of trans-Matrine and the Elusive cis-Matrine [PDF]

The Journal of Organic Chemistry, 2021
We characterized the bis-quinolizidine tetracyclic alkaloid (5S, 6S, 7R, 11R)-matrine in a supersonic jet expansion, using chirped-pulsed broadband microwave spectroscopy. Previous crystal diffraction analyses suggested 16 diastereoisomers associated with matrine's four carbon stereocenters but were inconclusive whether the lactamic nitrogen atom would
Juanes San José, Marcos, Saragi, Rizalina Tama, Enríquez Giraudo, María Lourdes, Jaraíz Maldonado, Martín, Lesarri Gómez, Alberto Eugenio   +4 more
openaire   +3 more sources

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production

Frontiers in Pharmacology, 2021
Matrine is a naturally occurring alkaloid and possesses a wide range of pharmacological properties, such as anti-cancer, anti-oxidant, anti-inflammatory effects. However, whether it affects platelet function and thrombosis remains unclear.
Sixuan Zhang, Sixuan Zhang, Sixuan Zhang, Xiang Gui, Xiang Gui, Xiang Gui, Yangyang Ding, Yangyang Ding, Yangyang Ding, Huan Tong, Huan Tong, Huan Tong, Wen Ju, Wen Ju, Wen Ju, Yue Li, Zhenyu Li, Zhenyu Li, Zhenyu Li, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Lingyu Zeng, Kailin Xu, Kailin Xu, Kailin Xu, Jianlin Qiao, Jianlin Qiao, Jianlin Qiao   +28 more
doaj   +1 more source