Results 21 to 30 of about 9,281 (250)

Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study.

PLoS ONE, 2023
Matrine, an alkaloid derived from herbal medicine, has a wide range of biological activities, including antibacterial. Matrine was toxic to multiple cells at high concentrations.
Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wang   +9 more
doaj   +1 more source

RETRACTED: Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion

Frontiers in Physiology, 2021
Matrine, an active component of Sophora flavescens Ait root extracts, has been used in China for years to treat cancer and viral hepatitis. In the present study, we explored the effects of matrine on hyperglycemia-treated cardiomyocytes.
Tong Xiao, Jie Huang, Yuan Liu, Yujie Zhao, Manman Wei   +4 more
doaj   +1 more source

Matrine inhibits the growth of natural killer/T-cell lymphoma cells by modulating CaMKIIγ-c-Myc signaling pathway

BMC Complementary Medicine and Therapies, 2020
Background C-Myc overexpression is associated with poor prognosis and aggressive progression of natural killer/T-cell lymphoma (NKTCL). Matrine, a main alkaloid of the traditional Chinese herb Sophora flavescens Ait, has been shown to inhibit cellular ...
Jianyou Gu, Yu Zhang, Xiao Wang, Jingjing Xiang, Shu Deng, Dijiong Wu, Junfa Chen, Lihong Yu, Yan Zhou, Yaokun Wang, Jianping Shen   +10 more
doaj   +1 more source

Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2022
Hepatocellular carcinoma (HCC) is a complex issue in cancer treatment in the world at present. Matrine is the main active ingredient isolated from Sophora flavescens air and possesses excellent antitumor effects in HCC.
Kexin Wang, Kexin Wang, Kexin Wang, Xiangmin Ye, Chuanhui Yin, Qing Ren, Qing Ren, Yupeng Chen, Xuemei Qin, Chuanzhi Duan, Aiping Lu, Li Gao, Daogang Guan, Daogang Guan   +13 more
doaj   +1 more source

Simultaneous extraction and purification of alkaloids from Sophora flavescens Ait. by microwave-assisted aqueous two-phase extraction with ethanol/ammonia sulfate system [PDF]

, 2015
A rapid and effective method of integrating extraction and purification for alkaloids from Sophora flavescens Ait. was developed by microwave-assisted aqueous two-phase extraction (MAATPE) based on the high efficiency of microwave-assisted extraction ...
Fan, Huajun, Liu, Peng, Liu, Xiaoqin, Tang, James Z., Wan, Qiang, Wu, Xuehao, Zhang, Wei, Zhu, Dan   +7 more
core   +1 more source

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]

, 2016
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar, Dave, Vivek S., Fegade, Harshal, Patin, Arun T., Pethe, Anil M., Telange, Darshan R.   +5 more
core   +2 more sources

Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

Frontiers in Pharmacology, 2018
After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate.
Norio Tanabe, Tomoharu Kuboyama, Chihiro Tohda   +2 more
doaj   +1 more source

Identification of candidate anti-cancer molecular mechanisms of compound kushen injection using functional genomics [PDF]

, 2016
Compound Kushen Injection (CKI) has been clinically used in China for over 15 years to treat various types of solid tumours. However, because such Traditional Chinese Medicine (TCM) preparations are complex mixtures of plant secondary metabolites, it is ...
Adelson, D., Cui, J., Feng, Q., Harata-Lee, Y., Kortschak, R., Qu, Z., Raison, J., Thazin Nwe Aung, T.   +7 more
core   +1 more source

Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice

Journal of Translational Medicine, 2023
Background The realization of the “microbiota–gut–brain” axis plays a critical role in neuropsychiatric disorders, particularly depression, is advancing rapidly.
M. Zhang, Aoqiang Li, Qifang Yang, Jingyi Li, Li-hua Zheng, Guannan Wang, Ying Sun, Yan-xin Huang, Muqing Zhang, Zhen-bo Song, Lei Liu   +10 more
semanticscholar   +1 more source

Matrine suppresses KRAS‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism

Molecular Oncology, 2018
Matrine is a natural compound extracted from the herb Sophora flavescens Ait which is widely used in traditional Chinese medicine for treating various diseases. Recently, matrine was reported to have antitumor effects against a variety of cancers without
Young‐ra Cho, Ji Hyeon Lee, Ji Hye Kim, So‐Yeon Lee, Suna Yoo, Min‐kyo Jung, Su Jung Kim, Hyun Ju Yoo, Chang‐Gi Pack, Jin Kyung Rho, Jaekyoung Son   +10 more
doaj   +1 more source