Results 21 to 30 of about 5,938 (234)

Matrisome gene expression is altered during non-allometric heart growth in genetically enlarged Drosophila [PDF]

bioRxiv
The cardiac extracellular matrix (ECM) is critical to defining the biophysical properties of the heart that adapt to changing stresses with growth or disease.
R. Andrews, J. R. Jacobs
semanticscholar   +2 more sources

Inflammation-related citrullination of matrisome proteins in human cancer

Frontiers in Oncology, 2022
IntroductionProtein arginine deiminases (PADs) are intracellular enzymes that may, especially in pathological conditions, also citrullinate extracellular substrates, including matrisome proteins such as structural proteins in extracellular matrix (ECM ...
Pekka Rappu, Ujjwal Suwal, Elina Siljamäki, Jyrki Heino   +3 more
doaj   +1 more source

The Matrisome Genes From Hepatitis B–Related Hepatocellular Carcinoma Unveiled

Hepatology Communications, 2021
Chronic hepatitis B virus (HBV) infection changes the composition of the extracellular matrix (ECM) and enables the onset and progression of hepatocellular carcinoma (HCC).
Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto   +8 more
doaj   +1 more source

Deciphering Age-Dependent ECM Remodelling in Liver: Proteomic Profiling and Its Implications for Aging and Therapeutic Targets. [PDF]

Cell Prolif
This study reveals age‐dependent remodelling of the liver extracellular matrix (ECM), identifying Lumican as a key regulator of hepatocyte proliferation and stemness in foetal development. Dynamic ECM shifts influence liver function, offering insights into therapeutic strategies for aging‐related hepatic decline.
Liu J, Song Q, Li C, Yan J, An N, Yin W, Diao J, Su Y, Wang Y.   +8 more
europepmc   +2 more sources

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl, David Wegrzyn, J. Bauch, A. Faissner   +3 more
semanticscholar   +1 more source

Extracellular matrix gene expression signatures as cell type and cell state identifiers

Matrix Biology Plus, 2021
Transcriptomic signatures based on cellular mRNA expression profiles can be used to categorize cell types and states. Yet whether different functional groups of genes perform better or worse in this process remains largely unexplored.
Fabio Sacher, Christian Feregrino, Patrick Tschopp, Collin Y. Ewald   +3 more
doaj   +1 more source

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Matrix Biology Plus, 2022
Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression.
Carson J. Cook, Andrew E. Miller, Thomas H. Barker, Yanming Di, Kaitlin C. Fogg   +4 more
doaj   +1 more source

Tissue, age, sex, and disease patterns of matrisome expression in GTEx transcriptome data

Scientific Reports, 2021
The extracellular matrix (ECM) has historically been explored through proteomic methods. Whether or not global transcriptomics can yield meaningful information on the human matrisome is unknown. Gene expression data from 17,382 samples across 52 tissues,
Tim O. Nieuwenhuis, Avi Z. Rosenberg, Matthew N. McCall, Marc K. Halushka   +3 more
doaj   +1 more source

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis [PDF]

, 2016
Cancer-associated fibroblasts (CAF) remain a poorly characterized, heterogeneous cell population. Here we characterized two previously described tumor-promoting CAF sub-types, smooth muscle actin (SMA)-positive myofibroblasts and senescent fibroblasts ...
Brennan, PA, Clarke, J, Eliceiri, KW, Ford, K, Frampton, S, Garcia, E, Gil, J, Hanley, CJ, Herranz, N, Kabir, TD, King, EV, Lambert, DW, Lim, KP, Mellone, M, Mellows, T, Moutasim, KA, Ottensmeier, CH, Prime, SS, Thirdborough, S, Thomas, GJ, Tod, J, Underwood, TJ, Venei, V, Venturi, G, Vijayanand, P, Woelk, C, Woo, J   +26 more
core   +5 more sources

Editorial: Recent advances in the pathogenesis and potential biomarkers of fibrosis [PDF]

Frontiers in Pharmacology
Samar A. Antar, Aymen Halouani, Karim Tawfic, Walied Abdo, Ayman M. Mahmoud, Yassine Sassi, Yassine Sassi, Yassine Sassi   +7 more
doaj   +2 more sources