Results 21 to 30 of about 5,313 (152)

Overexpression of the vitronectin v10 subunit in patients with nonalcoholic steatohepatitis: Implications for noninvasive diagnosis of NASH [PDF]

, 2018
Nonalcoholic steatohepatitis (NASH) is the critical stage of nonalcoholic fatty liver disease (NAFLD). The persistence of necroinflammatory lesions and fibrogenesis in NASH is the leading cause of liver cirrhosis and, ultimately, hepatocellular ...
Angelico, Francesco, Baratta, Francesco, Carpino, Guido, Del Ben, Maria, Gaudio, Eugenio, Labbadia, Giancarlo, Mancone, Carmine, Noce, Valeria, Overi, Diletta, Pastori, Daniele, Polimeni, Licia   +10 more
core   +2 more sources

Targeting Versican as a Potential Immunotherapeutic Strategy in the Treatment of Cancer

Frontiers in Oncology, 2021
A growing body of literature links events associated with the progression and severity of immunity and inflammatory disease with the composition of the tissue extracellular matrix as defined by the matrisome.
Priyanka Hirani, Valentine Gauthier, Carys E. Allen, Thomas N. Wight, Oliver M. T. Pearce   +4 more
doaj   +1 more source

Towards definition of an ECM parts list: An advance on GO categories [PDF]

, 2012
Those of us interested in the extracellular matrix (ECM) are faced with significant challenges of definition. ECM proteins are large, complex and assembled into crosslinked insoluble matrices.
Hoersch, Sebastian, Hynes, Richard O., Hynes, Richard O., Naba, Alexandra   +3 more
core   +1 more source

Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1⁺-Telocytes

Biomedicines, 2022
FoxL1+telocytes (TCFoxL1+) are novel gastrointestinal subepithelial cells that form a communication axis between the mesenchyme and epithelium. TCFoxL1+ are strategically positioned to be key contributors to the microenvironment through production and ...
Alain B. Alfonso, Véronique Pomerleau, Vilcy Reyes Nicolás, Jennifer Raisch, Carla-Marie Jurkovic, François-Michel Boisvert, Nathalie Perreault   +6 more
doaj   +1 more source

Spatial and temporal changes in extracellular elastin and laminin distribution during lung alveolar development [PDF]

, 2018
Lung alveolarization requires precise coordination of cell growth with extracellular matrix (ECM) synthesis and deposition. The role of extracellular matrices in alveogenesis is not fully understood, because prior knowledge is largely extrapolated from ...
Chen, Hui, Fernandez, G. Esteban, Krenitsky, Daria, Li, Nan, Luo, Yongfeng, Mecham, Robert P., Moats, Rex, Pryhuber, Gloria S., Shi, Wei, Warburton, David   +9 more
core   +2 more sources

Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease

Frontiers in Aging, 2022
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remodeling
Tinka Vidović, Collin Y. Ewald
doaj   +1 more source

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver [PDF]

, 2014
Background: Colorectal cancer is the third most frequently diagnosed cancer and the third cause of cancer deaths in the United States. Despite the fact that tumor cell-intrinsic mechanisms controlling colorectal carcinogenesis have been identified, novel
Carr, Steven A, Clauser, Karl R, Hynes, Richard O, Naba, Alexandra, Tanabe, Kenneth K, Whittaker, Charles A   +5 more
core   +2 more sources

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters [PDF]

, 2013
The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing ...
Anastassiades, Barry-Hamilton, Bergamaschi, Berra, Boudreau, Bulk, Cailleau, Chauhan, Chen, Comen, Conklin, Conklin, Curran, Dvorak, Egeblad, Erler, Finak, Fordyce, Geiger, Gillette, Goodman, Gygi, Györffy, Hynes, Hynes, Hynes, Jacobetz, Joyce, Klotzsche-von Ameln, Korpal, Lamar, Lamprecht, Leimeister, Massague, Minn, Minn, Munger, Naba, Padua, Padua, Paget, Pasche, Polyak, Ramirez, Rappsilber, Ribatti, Ryan, Sevenich, Sevenich, Stern, Tchou, Tlsty, Todorovic, Tsai, Tsai, Vasiljeva, Whatcott, Wilson, Yuan   +58 more
core   +2 more sources

The in-silico characterization of the Caenorhabditis elegans matrisome and proposal of a novel collagen classification

Matrix Biology Plus, 2019
Proteins are the building blocks of life. While proteins and their localization within cells and sub-cellular compartments are well defined, the proteins predicted to be secreted to form the extracellular matrix - or matrisome - remain elusive in the ...
Alina C. Teuscher, Elisabeth Jongsma, Martin N. Davis, Cyril Statzer, Jan M. Gebauer, Alexandra Naba, Collin Y. Ewald   +6 more
doaj   +1 more source

Pan-cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors. [PDF]

Int J Cancer
What's new? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Tang G, Liu X, Li Y, Ta Y, Cho M, Li H, Wang X.   +6 more
europepmc   +2 more sources