Results 21 to 30 of about 5,603 (226)

Matrisome Transcriptome Dynamics during Tissue Aging

Life
The extracellular matrix (ECM) is a complex three-dimensional network of macromolecules that provides structural support for the cells and plays a significant role in tissue homeostasis and repair.
Zulfiya G. Guvatova, Anastasiya A. Kobelyatskaya, Eveline R. Kudasheva, Elena A. Pudova, Elizaveta V. Bulavkina, Alexey V. Churov, Olga N. Tkacheva, Alexey A. Moskalev   +7 more
doaj   +3 more sources

A guide to building the matrisome interactome: from computational predictions to experimental validation. [PDF]

FEBS J
This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leverton L, Bains AK, Isa I, Ricard-Blum S, Naba A.   +4 more
europepmc   +2 more sources

The Matrisome, Inflammation, and Liver Disease [PDF]

Seminars in Liver Disease, 2020
AbstractChronic fatty liver disease is common worldwide. This disease is a spectrum of disease states, ranging from simple steatosis (fat accumulation) to inflammation, and eventually to fibrosis and cirrhosis if untreated. The fibrotic stage of chronic liver disease is primarily characterized by robust accumulation of extracellular matrix (ECM ...
Christine E, Dolin, Gavin E, Arteel
openaire   +2 more sources

Analysis of matrisome expression patterns in murine and human dorsal root ganglia

Frontiers in Molecular Neuroscience, 2023
The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into six different categories and are collectively called the matrisome.
Robin Vroman, Rahel S. Hunter, Matthew J. Wood, Olivia C. Davis, Zoë Malfait, Dale S. George, Dongjun Ren, Diana Tavares-Ferreira, Theodore J. Price, Richard J. Miller, Anne-Marie Malfait, Fransiska Malfait, Rachel E. Miller, Delfien Syx   +13 more
doaj   +1 more source

Single cell spatial profiling of the matrisome identifies region-specific adhesion and signaling networks in glioblastoma. [PDF]

Commun Biol
De A, Forero SA, Pirani A, Morales JE, De La Fuente-Granada M, Sebastian S, Huse JT, Ballester LY, Weinberg JS, Lang FF, Akdemir KC, McCarty JH.   +11 more
europepmc   +3 more sources

Divide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization [PDF]

International Journal of Molecular Sciences, 2020
Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unraveling its composition can we leverage related tissue engineering and pharmacological efforts. Nevertheless, its unbiased proteomic
Emna Ouni, Sébastien Pyr dit Ruys, Marie-Madeleine Dolmans, Gaëtan Herinckx, Didier Vertommen, Christiani A. Amorim   +5 more
openaire   +3 more sources

The cartilage matrisome in adolescent idiopathic scoliosis [PDF]

Bone Research, 2020
AbstractThe human spinal column is a dynamic, segmented, bony, and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility. Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.
Carol A. Wise, Diane Sepich, Aki Ushiki, Anas M. Khanshour, Yared H. Kidane, Nadja Makki, Christina A. Gurnett, Ryan S. Gray, Jonathan J. Rios, Nadav Ahituv, Lila Solnica-Krezel   +10 more
openaire   +4 more sources

Machine Learning Identifies Robust Matrisome Markers and Regulatory Mechanisms in Cancer [PDF]

International Journal of Molecular Sciences, 2020
The expression and regulation of matrisome genes—the ensemble of extracellular matrix, ECM, ECM-associated proteins and regulators as well as cytokines, chemokines and growth factors—is of paramount importance for many biological processes and signals within the tumor microenvironment.
Anni Kääriäinen, Vilma Pesola, Annalena Dittmann, Juho Kontio, Jarkko Koivunen, Taina Pihlajaniemi, Valerio Izzi   +6 more
openalex   +5 more sources

Bone-Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation. [PDF]

Adv Healthc Mater
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Dekker M, Hipwood L, Ravichandran A, Hutmacher DW, Meinert C, McGovern J.   +5 more
europepmc   +2 more sources

Pan-cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors. [PDF]

Int J Cancer
What's new? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Tang G, Liu X, Li Y, Ta Y, Cho M, Li H, Wang X.   +6 more
europepmc   +2 more sources