Results 61 to 70 of about 5,505 (195)

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

The matrisome landscape controlling in vivo germ cell fates

Nature Communications
The developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development.
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
doaj   +1 more source

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition [PDF]

, 2016
This study was funded by the BBSRC (BB/K008412/1)
A Franceschini, A Heinz, A Heinz, AA Biewener, B Kim, B Poulet, CT Thorpe, CT Thorpe, CT Thorpe, D Little, ER Ely, GA Lichtwark, H Mi, HL Birch, HL Birch, J Halper, J Melrose, JA Vizcaíno, JF Innes, JL Ireland, JM Whitelock, K Halasz, KE Kadler, KM Heinemeier, L Svensson, M Peffers, MJ Peffers, MJ Peffers, PE Hall, PJ Roughley, PPY Lui, PR Stephens, R Strocchi, RAE Clayton, RC Dwivedi, RK Smith, RM Korol, RO Hynes, S Kalamajski, SG Rees, SH Taylor, T Can, TM Grant, TM Ritty, X Liu, Y Kasashima, Y Sun, Y-L Sun   +47 more
core   +3 more sources

Injectable Biomimetic Composite Hydrogel Scaffold With Tissue‐Engineered Cartilage Matrix for Articular Cartilage Regeneration

Rare Metals, EarlyView.
ABSTRACT Articular cartilage regeneration remains a significant challenge because of its limited intrinsic healing capacity and the inadequacy of conventional treatments for restoring structural and functional integrity. In this study, a novel injectable composite hydrogel scaffold was designed to mimic the extracellular matrix (ECM) of native ...
Zhong‐Lian Wu, Jun‐Jie Jiang, Hang Yao, Xian‐Feng Shang, Ming‐Di Zheng, Xu Hu, Shuo Xu, Jun‐Li Shi, Yan Han, Chi‐Run Wang, Qi Tao, Huai‐Guo Xue, Dong‐An Wang, Yu‐Chi Zhao   +13 more
wiley   +1 more source

Analysis of cancer cell line and tissue RNA sequencing data reveals an essential and dark matrisome

Matrix Biology Plus
Extracellular matrix remodeling is a hallmark of tissue development, homeostasis, and disease. The processes that mediate remodeling, and the consequences of such, are the topic of extensive focus in biomedical research.
Joshua A. Rich, Yu Fan, Qingrong Chen, Daoud Meerzaman, William G. Stetler-Stevenson, David Peeney   +5 more
doaj   +1 more source

Quantifying the surface chemistry of 3D matrices in situ [PDF]

, 2014
Despite the major role of the matrix (the insoluble environment around cells) in physiology and pathology, there are very few and limited methods that can quantify the surface chemistry of a 3D matrix such as a biomaterial or tissue ECM.
So, Peter T. C., Tzeranis, Dimitrios S., Yannas, Ioannis V.   +2 more
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Epithelial cell integrin beta1 is required for developmental angiogenesis in the pituitary gland [PDF]

, 2016
As a key component of the vertebrate neuroendocrine system, the pituitary gland relies on the progressive and coordinated development of distinct hormone-producing cell types and an invading vascular network. The molecular mechanisms that drive formation
Krawczyk, M., Livolsi, A., Merkurjev, D., Rosenfeld, M. G., Scully, K. M., Skowronska-Krawczyk, D., Stan, R. V., Taylor, H., Tollkuhn, J.   +8 more
core   +2 more sources

The functional logic of corticostriatal connections [PDF]

, 2016
Unidirectional connections from the cortex to the matrix of the corpus striatum initiate the cortico-basal ganglia (BG)-thalamocortical loop, thought to be important in momentary action selection and in longer-term fine tuning of behavioural repertoire ...
Shipp, S
core   +1 more source

Molecular Landscape of TP53/RB1 Co‐Altered Tumors Uncovers Emerging Therapeutic Vulnerabilities

Genes, Chromosomes and Cancer, Volume 65, Issue 1, January 2026.
ABSTRACT Background Although TP53 and RB1 co‐alterations play critical roles in promoting malignant development and progression, specific inhibitors targeting this co‐alteration are lacking. We performed a pan‐cancer analysis to characterize the biology of TP53/RB1 co‐alterations and identify therapeutic strategies.
Xuetao Li, Meifeng Ye, Xiaomei Huang, Zhong‐Yin Huang, Juan Zhu, Zipeng He, Zhuxiang Zhao, Jun Hou, Shuquan Wei   +8 more
wiley   +1 more source