Results 61 to 70 of about 5,938 (234)

The Pathway Coexpression Network: Revealing pathway relationships. [PDF]

, 2018
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions.
A Alexeyenko, A Alexeyenko, A Brazma, A Burns, A Kumar, A Lewin, A Liberzon, A Naba, A Pujol, A Subramanian, A Thakur, A Zambrano, AA Sharov, AL Barabási, AL Barabási, B Efron, B Schreitmüller, C Ogris, CF Schaefer, Christina S. Leslie, Claire Green, D Croft, D Izawa, D Merico, D Nishimura, D Paris, D Warde-Farley, DR Rhodes, DR Rhodes, E Clough, E Eisenberg, FH Duits, FX Lepelletier, G Stelzer, Gabriel Altschuler, GE Landreth, GM Altschuler, GV Glazko, H Naeem, H Pearson, H Yan, HJM de Jonge, HR Frost, HR Frost, HS Le, J Caltagarone, J Dutkowski, J Pevsner, J Rung, J Schäfer, J Seita, J Weinstein, J Weinstein, JC Vivar, JF Rual, JH Hung, JS Miners, JT Leek, Katjuša Koler, KG Becker, L Matthews, L Thorrez, LG Bodea, M Ashburner, M de Jager, M Kanehisa, M Kanehisa, M Kanehisa, M Kramer, M Lukk, M Morawski, M Schena, ME Orcholski, MJ Macias, MJ Végh, MK Sethi, MM Almeida-de Macedo, MMM Wilhelmus, MN McCall, MN McCall, MN McCall, O Berezovska, O Ledoit, P Di Lena, P Scheltens, PL McGeer, R Isserlin, R Sherrington, R von Bernhardi, RJ Kelleher, RM Ewing, Rudolph E. Tanzi, S Bauer, S Catricala, S Davis, S Draghici, S Falcon, S Gaubatz, S Grossmann, S Lu, S Maere, S Ranganathan, Sokratis Kariotis, SY Kim, T Barrett, T Liptak, T McCormack, T Wang, TM Loughin, U Hassler, U Stelzl, V Popovici, VK Ramanan, W Fujibuchi, W Zhang, Wenbin Wei, Winston Hide, WR Markesbery, WS Liang, WT Barry, Y Benjamini, Y Huang, Y Kong, Y Li, Y Liu, Y Lu, Y Pritykin, Y Tan, Y Yamaguchi, Y Yu, Yered Pita-Juárez   +130 more
core   +4 more sources

Senescence-Associated Alterations in Matrisome of Mesenchymal Stem Cells

International Journal of Molecular Sciences
The process of aging is intimately linked to alterations at the tissue and cellular levels. Currently, the role of senescent cells in the tissue microenvironment is still being investigated.
Diana Matveeva, D. Kashirina, M. Ezdakova, I. Larina, L. Buravkova, A. Ratushnyy   +5 more
semanticscholar   +1 more source

Immune‐related matrisomes are potential biomarkers to predict the prognosis and immune microenvironment of glioma patients

FEBS Open Bio, 2023
The extracellular matrix (ECM) plays a vital role in the progression and metastasis of glioma and is an important part of the tumor microenvironment. The matrisome is composed of ECM components and related proteins. There have been several studies on the
Hao Yu, Minjie Wang, Xuan Wang, Xiaobing Jiang   +3 more
doaj   +1 more source

Quantitative proteomics identifies tumour matrisome signatures in patients with non-small cell lung cancer

Frontiers in Oncology, 2023
IntroductionThe composition and remodelling of the extracellular matrix (ECM) are important factors in the development and progression of cancers, and the ECM is implicated in promoting tumour growth and restricting anti-tumour therapies through multiple
Helen F. Titmarsh, Helen F. Titmarsh, Alex von Kriegsheim, Jimi C. Wills, Richard A. O’Connor, Kevin Dhaliwal, Margaret C. Frame, Samuel B. Pattle, David A. Dorward, David A. Dorward, Adam Byron, Adam Byron, Ahsan R. Akram, Ahsan R. Akram   +13 more
doaj   +1 more source

Global analysis of the heparin-enriched plasma proteome captures matrisome-associated proteins in Alzheimer’s disease

bioRxiv, 2023
Matrisome-associated heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD) brain and cerebrospinal fluid (CSF).
Qi Guo, Lingyan Ping, E. Dammer, D. Duong, Luming Yin, Kaiming Xu, A. Shantaraman, E. Fox, E. Johnson, Blaine R. Roberts, J. Lah, A. Levey, N. Seyfried   +12 more
semanticscholar   +1 more source

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Cell Reports, 2022
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression.
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron   +26 more
doaj   +1 more source

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation [PDF]

, 2021
The retinal extracellular matrix (ECM) provides architectural support, adhesion and signal guidance that controls retinal development. Decellularization of the ECM affords great potential to tissue engineering; however, how structural retinal ECM affects
Duarri, Anna, García Arumí, José, Maqueda, Maria, Mosquera Mayo, José Luís, Veiga, Anna   +4 more
core   +1 more source

Replication confers β cell immaturity. [PDF]

, 2018
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication.
Bengtsson, Henrik, French, Esra K, Hebrok, Matthias, Leonhardt, Laura, Puri, Sapna, Roy, Nilotpal, Roy, Ritu, Russ, Holger A, Scott, Donald K, Stewart, Andrew F   +9 more
core   +2 more sources

Matrisomal components involved in regenerative wound healing in axolotl and acomys: implications for biomaterial development [PDF]

, 2023
Achieving regeneration in humans has been a long-standing goal of many researchers. Whereas amphibians like the axolotl (Ambystoma mexicanum) are capable of regenerating whole organs and even limbs, most mammals heal their wounds via fibrotic scarring ...
Araujo, Ines, Avila-Martinez, Nancy, Daamen, Willeke F., Gansevoort, Merel, Jayaprakash, Haarshaadri, Tiscornia, Gustavo, van Kuppevelt, Toin H., Verbakel, Juul, Vitorino, Marta   +8 more
core   +1 more source