Results 61 to 70 of about 5,603 (226)

Proteomic differences between native and tissue-engineered tendon and ligament [PDF]

, 2016
Tendons and ligaments (T/Ls) play key roles in the musculoskeletal system, but they are susceptible to traumatic or age‐related rupture, leading to severe morbidity as well as increased susceptibility to degenerative joint diseases such as osteoarthritis.
Adirim, Ahmed, Bancroft, Bayer, Benjamin, Bergman, Beynnon, Birch, Burt, Butler, Calve, Canty, Canty, Cimino, Clegg, Comerford, Daniel, Farndale, Franceschini, Funakoshi, Hagerty, Herchenhan, Herchenhan, Hynes, Kapacee, Kapacee, Little, Maffulli, Maffulli, Mastrokalos, Naba, Paxton, Paxton, Peffers, Peffers, Raspanti, Rees, Reichenberg, Robertson, Rodrigues, Singer, Smith, Spindler, Strickland, Thorpe, Vogel, Woo, Young, Zhang   +48 more
core   +1 more source

Mutations in a set of ancient matrisomal glycoprotein genes across neoplasia predispose to disruption of morphogenetic transduction

Computational and Systems Oncology, 2022
Misexpression and remodeling of the extracellular matrix is a canonical hallmark of cancer, although the extent of cancer‐associated aberrations in the genes coding for extracellular matrix (ECM) proteins and the consequences thereof are not well ...
Jimpi Langthasa, Satyarthi Mishra, Monica U, Ronak Kalal, Ramray Bhat   +4 more
doaj   +1 more source

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients [PDF]

, 2016
We have previously identified UMP-CMP kinase (CMPK1) as a prognostic marker for triple negative breast cancer (TNBC) by mass spectrometry (MS).
Brask, J.B. (Julie Benedicte), Deurzen, C.H.M. (Carolien) van, Foekens, J.A. (John), Foekens, R. (Renée), Liu, N.Q. (Ning Qing), Look, M.P. (Maxime), Marchi, T. (Tommaso) de, Martens, J.W.M. (John), Smid, M. (Marcel), Span, P.N. (Paul), Sweep, F.C. (Fred), Timmermans, A.M. (Annemieke), Timmermans-Wielenga, V. (Vera), Trapman-Jansen, A.M.A.C. (Anita M.A.C.), Umar, A. (Arzu)   +14 more
core   +1 more source

Alterations of Matrisome Gene Expression in Naturally Aged and Photoaged Human Skin In Vivo

Biomolecules
The main component of human skin is a collagen-rich extracellular matrix (ECM), known as the matrisome. The matrisome is essential for maintaining the structural integrity and mechanical properties of the skin.
Yan Yan, Hehui Quan, Chunfang Guo, Zhaoping Qin, Taihao Quan   +4 more
doaj   +1 more source

Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes [PDF]

, 2014
Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal gynaecological malignancy in the Western world. Therapeutic approaches need to account for inter-patient and intra-tumoural heterogeneity and detailed ...
Beaufort, C.M. (Corine M.), Berns, P.M.J.J. (Els), Besselink, N. (Nicolle), Brenton, J.D. (James D.), Heine, A.A.J. (Anouk), Helleman, J. (Jozien), Helmijr, J. (Jean), Hoogstraat, M. (Marlous), IJcken, W.F.J. (Wilfred) van, Koudijs, M.J. (Marco J.), Murtaza, M. (Muhammed), Piskorz, A.M. (Anna M.), Ruigrok-Ritstier, K. (Kirsten), Smid, M. (Marcel)   +13 more
core   +1 more source

Matrisome Profiling During Intervertebral Disc Development And Ageing

Scientific Reports, 2017
AbstractIntervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investigation.
Caldeira, Joana B., Santa, Cátia, Osório, Hugo, Molinos, Maria, Manadas, Bruno, Gonçalves, Raquel, Barbosa, Mário   +6 more
openaire   +3 more sources

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

Cell, 2022
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear. Here, we investigated the effects of APOE4 on brain cell types derived from population and isogenic human induced pluripotent stem cells, post-mortem brain, and APOE targeted replacement mice ...
Julia TCW, Lu Qian, Nina H. Pipalia, Michael J. Chao, Shuang A. Liang, Yang Shi, Bharat R. Jain, Sarah E. Bertelsen, Manav Kapoor, Edoardo Marcora, Elizabeth Sikora, Elizabeth J. Andrews, Alessandra C. Martini, Celeste M. Karch, Elizabeth Head, David M. Holtzman, Bin Zhang, Minghui Wang, Frederick R. Maxfield, Wayne W. Poon, Alison M. Goate   +20 more
openaire   +4 more sources

Proteomic Identification of a Gastric Tumor ECM Signature Associated With Cancer Progression

Frontiers in Molecular Biosciences, 2022
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression.
Ana M. Moreira, Ana M. Moreira, Ana M. Moreira, Rui M. Ferreira, Rui M. Ferreira, Patrícia Carneiro, Patrícia Carneiro, Joana Figueiredo, Joana Figueiredo, Hugo Osório, Hugo Osório, Hugo Osório, José Barbosa, José Barbosa, John Preto, John Preto, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Perpétua Pinto-do-Ó, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Fátima Carneiro, Raquel Seruca, Raquel Seruca, Raquel Seruca   +25 more
doaj   +1 more source

Insider Trading:Extracellular Matrix Proteins and their Non-Canonical Intracellular Roles [PDF]

, 2015
In metazoans, the extracellular matrix (ECM) provides a dynamic, heterogeneousmicroenvironment that has important supportive and instructive roles.
Adams, Josephine C, Hellewell, Andrew L
core   +2 more sources

A pan-cancer analysis of matrisome proteins reveals CTHRC1 and a related network as major ECM regulators across cancers.

PLoS ONE, 2022
The extracellular matrix in the tumour microenvironment can regulate cancer cell growth and progression. A pan-cancer analysis of TCGA data from 30 cancer types, identified the top 5% of matrisome genes with amplifications or deletions in their copy ...
Keerthi Harikrishnan, Srinivas Sheshagiri Prabhu, Nagaraj Balasubramanian   +2 more
doaj   +2 more sources