Results 71 to 80 of about 5,603 (226)

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

eLife, 2021
Collagen-rich tissues have poor reparative capacity that predisposes to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, and skin of ...
Yoanna Ariosa-Morejon, Alberto Santos, Roman Fischer, Simon Davis, Philip Charles, Rajesh Thakker, Angus KT Wann, Tonia L Vincent   +7 more
doaj   +1 more source

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

Pan-cancer analysis connects tumor matrisome to immune response [PDF]

npj Precision Oncology, 2019
Abstract Recent sequencing efforts unveil genomic landscapes of tumor microenvironment. A key compartment in this niche is the extracellular matrix (ECM) and its related components – matrisome.
Su Bin Lim, Melvin Lee Kiang Chua, Joe Poh Sheng Yeong, Swee Jin Tan, Wan-Teck Lim, Chwee Teck Lim   +5 more
openaire   +2 more sources

Atlas of mildly and highly insoluble matrisome driving liver fibrosis

Frontiers in Pharmacology
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis.
Wen Zhang, Wen Zhang, Wen Zhang, Ning Zhang, Ning Zhang, Ning Zhang, Wenyue Wu, Wenyue Wu, Wenyue Wu, Hong Li, Hong Li, Hong Li, Hong Li, Hong You, Hong You, Hong You, Wei Chen, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +20 more
doaj   +1 more source

Time-Resolved Extracellular Matrix Atlas of the Developing Human Skin Dermis

Frontiers in Cell and Developmental Biology, 2021
Skin aging is a physiological issue that is still relatively poorly understood. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging.
Mansheng Li, Xiao Li, Binghui Liu, Luye Lv, Wenjuan Wang, Dunqin Gao, Qiyu Zhang, Junyi Jiang, Mi Chai, Zhimin Yun, Yingxia Tan, Feng Gong, Zhihong Wu, Yunping Zhu, Yunping Zhu, Jie Ma, Ling Leng   +16 more
doaj   +1 more source

The Pathway Coexpression Network: Revealing pathway relationships. [PDF]

, 2018
A goal of genomics is to understand the relationships between biological processes. Pathways contribute to functional interplay within biological processes through complex but poorly understood interactions.
A Alexeyenko, A Alexeyenko, A Brazma, A Burns, A Kumar, A Lewin, A Liberzon, A Naba, A Pujol, A Subramanian, A Thakur, A Zambrano, AA Sharov, AL Barabási, AL Barabási, B Efron, B Schreitmüller, C Ogris, CF Schaefer, Christina S. Leslie, Claire Green, D Croft, D Izawa, D Merico, D Nishimura, D Paris, D Warde-Farley, DR Rhodes, DR Rhodes, E Clough, E Eisenberg, FH Duits, FX Lepelletier, G Stelzer, Gabriel Altschuler, GE Landreth, GM Altschuler, GV Glazko, H Naeem, H Pearson, H Yan, HJM de Jonge, HR Frost, HR Frost, HS Le, J Caltagarone, J Dutkowski, J Pevsner, J Rung, J Schäfer, J Seita, J Weinstein, J Weinstein, JC Vivar, JF Rual, JH Hung, JS Miners, JT Leek, Katjuša Koler, KG Becker, L Matthews, L Thorrez, LG Bodea, M Ashburner, M de Jager, M Kanehisa, M Kanehisa, M Kanehisa, M Kramer, M Lukk, M Morawski, M Schena, ME Orcholski, MJ Macias, MJ Végh, MK Sethi, MM Almeida-de Macedo, MMM Wilhelmus, MN McCall, MN McCall, MN McCall, O Berezovska, O Ledoit, P Di Lena, P Scheltens, PL McGeer, R Isserlin, R Sherrington, R von Bernhardi, RJ Kelleher, RM Ewing, Rudolph E. Tanzi, S Bauer, S Catricala, S Davis, S Draghici, S Falcon, S Gaubatz, S Grossmann, S Lu, S Maere, S Ranganathan, Sokratis Kariotis, SY Kim, T Barrett, T Liptak, T McCormack, T Wang, TM Loughin, U Hassler, U Stelzl, V Popovici, VK Ramanan, W Fujibuchi, W Zhang, Wenbin Wei, Winston Hide, WR Markesbery, WS Liang, WT Barry, Y Benjamini, Y Huang, Y Kong, Y Li, Y Liu, Y Lu, Y Pritykin, Y Tan, Y Yamaguchi, Y Yu, Yered Pita-Juárez   +130 more
core   +4 more sources

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion

Cell Reports, 2022
Summary: In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression.
Elizabeth R. Murray, Shinelle Menezes, Jack C. Henry, Josie L. Williams, Lorena Alba-Castellón, Priththivika Baskaran, Ivan Quétier, Ami Desai, Jacqueline J.T. Marshall, Ian Rosewell, Marianthi Tatari, Vinothini Rajeeve, Faraz Khan, Jun Wang, Panoraia Kotantaki, Eleanor J. Tyler, Namrata Singh, Claire S. Reader, Edward P. Carter, Kairbaan Hodivala-Dilke, Richard P. Grose, Hemant M. Kocher, Nuria Gavara, Oliver Pearce, Pedro Cutillas, John F. Marshall, Angus J.M. Cameron   +26 more
doaj   +1 more source

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition [PDF]

, 2016
This study was funded by the BBSRC (BB/K008412/1)
A Franceschini, A Heinz, A Heinz, AA Biewener, B Kim, B Poulet, CT Thorpe, CT Thorpe, CT Thorpe, D Little, ER Ely, GA Lichtwark, H Mi, HL Birch, HL Birch, J Halper, J Melrose, JA Vizcaíno, JF Innes, JL Ireland, JM Whitelock, K Halasz, KE Kadler, KM Heinemeier, L Svensson, M Peffers, MJ Peffers, MJ Peffers, PE Hall, PJ Roughley, PPY Lui, PR Stephens, R Strocchi, RAE Clayton, RC Dwivedi, RK Smith, RM Korol, RO Hynes, S Kalamajski, SG Rees, SH Taylor, T Can, TM Grant, TM Ritty, X Liu, Y Kasashima, Y Sun, Y-L Sun   +47 more
core   +3 more sources