Results 71 to 80 of about 5,938 (234)

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

bioRxiv, 2023
Extracellular matrix (ECM) tumorigenic alterations resulting in high matrix deposition and stiffening are hallmarks of adenocarcinomas and are collectively defined as desmoplasia. Here, we thoroughly analysed primary prostate cancer tissues obtained from
S. Fernandes, Jorge Oliver-De La Cruz, M. Cassani, Sofia Morazzo, H. Durikova, A. Caravella, Piergiuseppe Fiore, Giulia Azzato, G. De Marco, A. Lauria, V. Izzi, V. Bosáková, J. Frič, P. Filipensky, G. Forte   +14 more
semanticscholar   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Cellular and Molecular Life Sciences, 2023
Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins.
Salome M. Brütsch, E. Madzharova, S. Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, A. Gazdhar, G. Kuhn, P. Angel, S. Bellusci, J. Brinckmann, U. auf dem Keller, Sabine Werner, M. R. Bordoli   +13 more
semanticscholar   +1 more source

Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture

Advanced Science, EarlyView.
Matrigel remains the most widely used scaffold in organoid and 3D culture despite its murine origin, variability, and translational limitations. This review discusses the barriers to replacing Matrigel with xeno‐free alternatives and introduces practical tools, including a matrix selection checklist and scaffold assessment criteria, to guide the ...
Lisa Wolff, Sven Hendrix
wiley   +1 more source

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition [PDF]

, 2016
This study was funded by the BBSRC (BB/K008412/1)
A Franceschini, A Heinz, A Heinz, AA Biewener, B Kim, B Poulet, CT Thorpe, CT Thorpe, CT Thorpe, D Little, ER Ely, GA Lichtwark, H Mi, HL Birch, HL Birch, J Halper, J Melrose, JA Vizcaíno, JF Innes, JL Ireland, JM Whitelock, K Halasz, KE Kadler, KM Heinemeier, L Svensson, M Peffers, MJ Peffers, MJ Peffers, PE Hall, PJ Roughley, PPY Lui, PR Stephens, R Strocchi, RAE Clayton, RC Dwivedi, RK Smith, RM Korol, RO Hynes, S Kalamajski, SG Rees, SH Taylor, T Can, TM Grant, TM Ritty, X Liu, Y Kasashima, Y Sun, Y-L Sun   +47 more
core   +3 more sources

Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices

Stem cell research & therapeutics, 2023
Background The vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied.
S. R. Moura, Jaime Freitas, C. Ribeiro-Machado, Jorge Lopes, N. Neves, H. Canhão, A. M. Rodrigues, M. Barbosa, M. Almeida   +8 more
semanticscholar   +1 more source

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Quantifying the surface chemistry of 3D matrices in situ [PDF]

, 2014
Despite the major role of the matrix (the insoluble environment around cells) in physiology and pathology, there are very few and limited methods that can quantify the surface chemistry of a 3D matrix such as a biomaterial or tissue ECM.
So, Peter T. C., Tzeranis, Dimitrios S., Yannas, Ioannis V.   +2 more
core   +1 more source

Pan‐cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors

International Journal of Cancer, EarlyView.
What's New? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Gongyu Tang, Xinyi Liu, Yuanxiang Li, Yunfei Ta, Minsu Cho, Hua Li, Xiaowei Wang   +6 more
wiley   +1 more source

The evolution of metazoan extracellular matrix [PDF]

, 2011
The modular domain structure of extracellular matrix (ECM) proteins and their genes has allowed extensive exon/domain shuffling during evolution to generate hundreds of ECM proteins.
Adams, Aouacheria, Ball, Barros, Bentley, Bergmeier, Boute, Chapman, Chiquet-Ehrismann, Couchman, Dehal, Engel, Ewan, Exposito, Exposito, Fahey, Gazave, Heino, Hohenester, Huhtala, Hutter, Huxley-Jones, Hynes, Hynes, Hynes, Hynes, King, King, Knack, Martindale, Merline, Myllyharju, Naba, Ozbek, Patthy, Philippe, Philippe, Pick, Putnam, Putnam, Ricard-Blum, Richard O. Hynes, Robertson, Sadler, Schaefer, Schierwater, Sebé-Pedrós, Shalchian-Tabrizi, Srivastava, Srivastava, Tucker, Wada, Whittaker, Whittaker, Yurchenco, Zhang   +55 more
core   +1 more source