Results 271 to 280 of about 246,652 (309)

Matrix metalloproteinase-1 treatment of muscle fibrosis

Acta Biomaterialia, 2008
The onset of scarring after injury may impede the regeneration and functional recovery of skeletal muscle. Matrix metalloproteinase-1 (MMP-1) hydrolyzes type I collagen and thus may improve muscle regeneration by resolving fibrotic tissue. We examined the effect of recombinant human MMP-1 on fibrosis in the lacerated gastrocnemius muscle of NOD/scid ...
Joel L, Kaar, Yong, Li, Harry C, Blair, Gemma, Asche, Richard R, Koepsel, Johnny, Huard, Alan J, Russell   +6 more
openaire   +2 more sources

Matrix metalloproteinase-1 therapy improves muscle healing

Journal of Applied Physiology, 2007
Muscle undergoes time-dependent phases of healing after injury, which ultimately results in residual fibrosis in the injured area. The use of exogenous matrix metalloproteinases (MMPs) may improve recovery after muscle injury by promoting the digestion of existing fibrous tissue and releasing local growth factors.
Hany, Bedair, T Thomas, Liu, Joel L, Kaar, Shawn, Badlani, Alan J, Russell, Yong, Li, Johnny, Huard   +6 more
openaire   +2 more sources

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Journal of Nanjing Medical University, 2007
Objective: To explore the role of matrix metalloproteinase-1, 2 (MMP-1, MMP-2) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in endometriosis. Methods: The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.
Rong Liu, Demin Pu, Dan Yang
openaire   +1 more source

Role of matrix metalloproteinase-2, matrix metalloproteinase-9, and tissue inhibitors of metalloproteinase-1 in recurrent depression

The Scientific Journal of Al-Azhar Medical Faculty, Girls, 2020
Objectives Matrix metalloproteinases (MMPs) play a major role in inflammatory processes, and their effect in depression has been examined. This study evaluates MMP-2, MMP-9, and tissue inhibitors of metalloproteinase-1 (TIMP-1) in patients with major depressive disorder and in a control group of healthy individuals, as well as correlation between their
RaniaA Hamed, HebaA Elmalt, AbeerA.A Salama, SarahY Abozaid, ShaimaaY Abd Elaziz   +4 more
openaire   +1 more source

Plasmin activates pro‐matrix metalloproteinase‐2 with a membrane‐type 1 matrix metalloproteinase‐dependent mechanism

Journal of Cellular Physiology, 2002
AbstractMembrane‐type 1 matrix metalloproteinase (MT1‐MMP) has been implicated as a physiological activator of progelatinase A (MMP‐2). We previously reported that plasmin treatment of cells results in proMMP‐2 activation and increased type IV collagen degradation. Here, we analyzed the role of MT1‐MMP in plasmin activation of MMP‐2 using HT‐1080 cells
Sara, Monea, Kaisa, Lehti, Jorma, Keski-Oja, Paolo, Mignatti   +3 more
openaire   +2 more sources

Diagnostic value of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinases 1 in cholesteatoma.

Histology and histopathology, 2016
Matrix metalloproteinase 9 (MMP-9), able to degrade type IV collagen, plays a key role in inflammatory cell migration as well as in the destructive behaviour of cholesteatoma. The aim of our study was to compare the expression of MMP-9 and TIMP-1 in cholesteatoma tissue and in the concentrations in serum and plasma concentrations.Twenty five adult ...
Ewa, Olszewska, Marlena, Matulka, Barbara, Mroczko, Anna, Pryczynicz, Andrzej, Kemona, Maciej, Szmitkowski, Jozef, Mierzwinski, Tymoteusz, Pietrewicz   +7 more
openaire   +2 more sources

Matrix metalloproteinase-1 and skin ageing in smokers

The Lancet, 2001
Smokers look older than non-smokers of the same age. We have compared the concentrations of mRNA for matrix metalloproteinase 1 (MMP-1) in the buttock skin of smokers and non-smokers with quantitative real-time polymerase chain reactions. MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis.
Lahmann, C, Bergemann, J, Harrison, G, Young, A R   +3 more
openaire   +3 more sources

Matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in vesicoureteral reflux

Pediatric Nephrology, 2011
The aim of this study was to investigate whether urine levels of matrix metalloproteinase 9 (uMMP9) and tissue inhibitor of metalloproteinase 1 (uTIMP1) are novel biomarkers of vesicoureteral reflux (VUR) and to determine the optimal cut-off levels of these enzymes to predict VUR in children.
Alev, Yilmaz, Ilmay, Bilge, Aysel, Kiyak, Asuman, Gedikbasi, Aysegul, Sucu, Bagdagul, Aksu, Sevinc, Emre, Aydan, Sirin   +7 more
openaire   +2 more sources

Expression of matrix metalloproteinase‐1, matrix metalloproteinase‐2 and extracellular metalloproteinase inducer in human periodontal ligament cells stimulated with interleukin‐1beta

Journal of Periodontal Research, 2009
Background and Objectives:  Matrix metalloproteinases (MMPs), produced by both infiltrating and resident cells of the periodontium, play important roles in physiologic and pathologic events. Both interleukin‐1beta and extracellular MMP inducer can stimulate the expression of MMPs, which in turn leads to breakdown of the periodontium.
J, Xiang, C, Li, W, Dong, Z, Cao, L, Liu
openaire   +2 more sources

Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure

American Heart Journal, 2005
Extracellular matrix remodeling is thought to play an important role in the progression of heart failure (HF). Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are matrix-degrading enzymes that have been demonstrated to influence left ventricular properties and serve as targets of potential anti-remodeling agents ...
Jacob, George, Shuki, Patal, Dov, Wexler, Arie, Roth, David, Sheps, Gad, Keren   +5 more
openaire   +2 more sources