Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy [PDF]
Pharmaceuticals, 2020 Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2.
Antonio Laghezza +11 more
doaj +2 more sources
Molecular Imaging Probes Based on Matrix Metalloproteinase Inhibitors (MMPIs) [PDF]
Molecules, 2019 Matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases which are secreted or anchored in the cell membrane and are capable of degrading the multiple components of the extracellular matrix (ECM).
Loganathan Rangasamy +6 more
doaj +2 more sources
Discovery and Characterisation of Novel Poly-Histidine-Poly-Glycine Peptides as Matrix Metalloproteinase Inhibitors [PDF]
BiomoleculesFor the first time, two poly-histidine-poly-glycine peptides (pHpG-H5 and pHpG-H7) were identified as promising candidates for matrix metalloproteinase inhibitors. cDNAs encoding pHpG-H5 and pHpG-H7 peptides were isolated from the Atheris squamigera cDNA
He Wang +8 more
doaj +2 more sources
Matrix Metalloproteinase Inhibitors and Their Potential Clinical Application in Periodontitis [PDF]
DiseasesMatrix metalloproteinases (MMPs) are a family of endopeptidases recognized for their involvement in the degradation of the extracellular matrix and their important role in the pathogenesis of periodontitis.
Daniela Mendoza-Juárez +5 more
doaj +2 more sources
The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma [PDF]
Cells, 2019 The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs as therapeutic targets.
Gregg B. Fields
doaj +2 more sources
MMpI: A WideRange of Available Compounds of Matrix Metalloproteinase Inhibitors. [PDF]
PLoS ONE, 2016 Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases involved in the regulation of the extracellular signaling and structural matrix environment of cells and tissues.
Charuvaka Muvva +2 more
doaj +2 more sources
Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2018 Mycobacterium tuberculosis (Mtb) remains a grave threat to world health with emerging drug resistant strains. One prominent feature of Mtb infection is the extensive reprogramming of host tissue at the site of infection. Here we report that inhibition of
Yitian Xu +12 more
doaj +2 more sources
Matrix metalloproteinase inhibitors in restorative dentistry. [PDF]
J Conserv Dent EndodAbstract Matrix metalloproteinases (MMPs) have been identified as agents that disintegrate the collagen structures of dental hybrid layers, resulting in reduced restorative bond strength. Multiple MMP inhibitors (MMPIs) are known to counteract this degenerative mechanism, thereby preserving bond strength and promoting the longevity of resin ...
Perarivalan I +4 more
europepmc +3 more sources
ELECTRON WITHDRAWING GROUP EFFECT ON BIOLOGICAL ACTIVITIES OF PYRIMIDINE HYBRIDS AS POTENTIAL ANTI-MATRIX METALLOPROTEINASE-7 [PDF]
Química Nova, 2023 We investigated the effect of both electron donating group and e//lectron withdrawing group on biological activity of pyrimidine-based compounds as metalloproteinase-7 inhibitors and predicting a library of drug-like compounds with potent cytotoxicity ...
Abel Kolawole Oyebamiji +7 more
doaj +1 more source
Matrix metalloproteinases and their inhibitors
Фармакокинетика и Фармакодинамика, 2019 Metalloproteinase was discovered by Gross and Lapierre in 1962 for the first time. Since then, more than 20 enzymes of this family have been characterized, and their functions have been studied in detail.
O. S. Grigorkevich +2 more
doaj +1 more source