Results 91 to 100 of about 156,207 (304)

Phase Field Failure Modeling: Brittle‐Ductile Dual‐Phase Microstructures under Compressive Loading

Advanced Engineering Materials, EarlyView.
The approach by Amor and the approach by Miehe and Zhang for asymmetric damage behavior in the phase field method for fracture are compared regarding their fitness for microcrack‐based failure modeling. The comparison is performed for the case of a dual‐phase microstructure with a brittle and a ductile constituent.
Jakob Huber, Jan Torgersen, Ewald Werner
wiley   +1 more source

Microstructure‐Controlled Crack Propagation and Fracture Resistance in MoSiBTiC Alloy Revealed by Multiscale Extended Finite Element Method Modeling

Advanced Engineering Materials, EarlyView.
A two‐dimensional multiscale finite element analysis framework was established for the first‐generation MoSiBTiC alloy, and the mechanical and fracture‐related parameters of the constituent phases were calibrated through experiments and simulations. The framework provides a basis for analyzing crack propagation behavior in its complex microstructure ...
Junfeng Du, Takahiro Kaneko, Xinyu Yan, Takahito Ohmura, Kyosuke Yoshimi   +4 more
wiley   +1 more source

Gastric Cancer Actively Remodels Mechanical Microenvironment to Promote Chemotherapy Resistance via MSCs‐Mediated Mitochondrial Transfer

Advanced Science
Chemotherapy resistance is the main reason of treatment failure in gastric cancer (GC). However, the mechanism of oxaliplatin (OXA) resistance remains unclear.
Xin He, Li Zhong, Nan Wang, Baiwei Zhao, Yannan Wang, Xinxiang Wu, Changyu Zheng, Yueheng Ruan, Jianfeng Hou, Yusheng Luo, Yuehan Yin, Yulong He, Andy Peng Xiang, Jiancheng Wang   +13 more
doaj   +1 more source

Simvastatin attenuates matrix stiffness-mediated traction forces.

, 2016
Cellular traction forces in endothelial cells increase with matrix stiffness but are attenuated with 1 μM simvastatin treatment. (A) Representative traction stress maps for endothelial cells at each level of matrix stiffness with and without simvastatin ...
John Huynh (704557), Cynthia A. Reinhart-King (218276), Courtney J. Faber (845610), Marsha C. Lampi (845609), Matthew R. Zanotelli (845611), Francois Bordeleau (5666464)   +5 more
core   +1 more source

High‐Temperature Nanoindentation of Metals: Assessing Thermal Drift, Frame Compliance, and Chemical Composition Effects on the Reported Mechanical Properties

Advanced Engineering Materials, EarlyView.
Do not let thermal drift and instrument artifacts deceive high‐temperature nanoindentation results. We compare classical Oliver–Pharr and automatic image recognition analyses across steels and a Ni alloy to quantify these effects. Accounting for artifacts reveals systematic softening with temperature, while Cr and Ni additions boost resistance ...
Velislava Yonkova, Steffen Brinckmann, Ruth Schwaiger   +2 more
wiley   +1 more source

The Effect of Scaffold Modulus on the Morphology and Remodeling of Fetal Mesenchymal Stem Cells

Frontiers in Physiology, 2018
Hydrogel materials have been successfully used as matrices to explore the role of biophysical and biochemical stimuli in directing stem cell behavior. Here, we present our findings on the role of modulus in guiding bone marrow fetal mesenchymal stem cell
Abdul Jalil Rufaihah, Suganya Cheyyatraivendran, Muhammad Danial Mohd Mazlan, Kenrich Lim, Mark Seow Khoon Chong, Citra Nurfarah Zaini Mattar, Jerry Kok Yen Chan, Theodoros Kofidis, Theodoros Kofidis, Dror Seliktar, Dror Seliktar   +10 more
doaj   +1 more source

Stiffness Matrix of Nonlinear FEM Equilibrium Equation

, 2012
For structural stability analysis, either tangent stiffness matrix or secant stiffness matrix is used depending on different situations. In this study, the general mathematic relationship between structural secant and tangent stiffness matrices is ...
Yumei, Li, Jian, Liu, Yun, Tian
core   +1 more source

Exploiting Matrix Stiffness to Overcome Drug Resistance

ACS Biomaterials Science & Engineering
Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the
Hakan Berk Aydin, Altug Ozcelikkale, Ahmet Acar   +2 more
openaire   +4 more sources

Wound Matrix Stiffness Imposes on Macrophage Activation

, 2020
The immune system depends on two major paths-the innate and the adaptive immunity. Macrophage, with its unique features as the first line of immune defense to engulf and digest invaders, serves as the key effector cells integrating those two paths. The dynamic plasticity of macrophage activation during wound repair, inflammation resolution, and tissue ...
Pu, Duann, Pei-Hui, Lin
openaire   +3 more sources

Optimization of the Production of Rubber Compounds Using Mathematical Models

Advanced Engineering Materials, EarlyView.
Rubber compounds were mixed in a batch internal mixer, and symbolic regression was used to derive mathematical models linking recipe and process parameters to ram path, torque, and mixing quality (incorporation, dispersion, distribution). Subsequent optimization with evolutionary algorithms identified operating conditions that reduce specific energy ...
Anke Bardehle, Andreas Limper, Ulrich Giese, Carlos Lucke, Mario Beiner, Christoph Gögelein, Lisa Leuchtenberger‐Engel, Christian Hopmann   +7 more
wiley   +1 more source