Results 31 to 40 of about 33,810 (257)

A Tablet Matrix with Hibiscus rosa Sinensis Leave Mucilage for Effective Treatment of Rare Lymphangioleiomyomatosis Using Sirolimus [PDF]

Trends in Pharmaceutical Sciences, 2022
Using a blend of herbal and synthetic polymers, the authors aim to extend the release of Sirolimus from the tablets. Sirolimus was used as a model drug, Hydroxy Propyl Methyl Cellulose was used as a synthetic polymer, and mucilage from Hibiscus rosa ...
Hindustan Abdul Ahad, Haranath Chinthaginjala, Yarragunta Roja, Kandlapalli Swathi, Pandre Shravya, Anam Rashi   +5 more
doaj   +1 more source

Design and evaluation of a metronidazole central core matrix tablet

Journal of Advanced Pharmaceutical Technology & Research, 2010
In this paper, a study of different concentration of HPMC K 15 M exerts influence on the drug release process from a new controlled drug delivery system has been realized in order to obtain a constant release rate during a prolonged period of time, for a programmed drug release. The drug release profiles obtained for the different batches have shown an
S.D.Tonpay, Vandana Chaudhary, Upendra Nagaich, Roopa Karki   +3 more
openaire   +4 more sources

Sustained Release Matrix Tablet: An Overview

Asian Journal of Pharmaceutical Research and Development, 2021
Sustained Release is also a promising method for reducing medication side effects by preventing the therapeutic concentration of the drug from fluctuating in the body.The basic rationale of a sustained drug delivery system is to optimise a drug's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to maximise utility, minimise ...
Rajkumar Prasad Yadav, H. S Keerthy, Mandev Mehta   +2 more
openaire   +1 more source

Development and evaluation of Ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage

Saudi Pharmaceutical Journal, 2017
Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations as valuable drug excipient. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable.
M. Kaleemullah, K. Jiyauddin, E. Thiban, S. Rasha, S. Al-Dhalli, S. Budiasih, O.E. Gamal, A. Fadli, Y. Eddy   +8 more
doaj   +1 more source

Exploration of Neusilin^® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study

Pharmaceutics, 2022
Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in ...
Tomáš Bílik, Jakub Vysloužil, Martina Naiserová, Jan Muselík, Miroslava Pavelková, Josef Mašek, Drahomíra Čopová, Martin Čulen, Kateřina Kubová   +8 more
doaj   +1 more source

Developing Composition and Technology of Ethylthiobenzimidazole Fumarate Matrix Tablets According to Specified Release Profile

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Ethylthiobenzimidazole fumarate (ETBIF) is a new actoprotector and adaptogenic active pharmaceutical ingredient (API). ETBIF was found to be effective given in short intervals; side effects related to ETBIF stomach solubility are known ...
I. D. Kasymov, A. L. Marchenko, A. V. Basevich   +2 more
doaj   +1 more source

The effect of hydrophilic and hydrophobic polymers on release profiles of diclofenac sodium from matrix tablets

Archives of Pharmacy Practice, 2013
Objective: The current study aimed to develop a matrix type sustained release Diclofenac tablet, using hydrophilic hydroxypropyl methylcellulose (HPMC) and hydrophobic polymer cetyl alcohol (CA).
Md Imamul Islam, Md Kamal Hossain, Taksim Ahmed, Prabhat Bhusal, Md Sohel Rana, Tanveer A Khan   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Grafted tamarind kernel polysaccharide based Al3+ cross-linked hydrogel matrices for sustained release of drug in the gastrointestinal milieu

Pharmaceutical Science Advances
Ionically cross-linked hydrogel serves as an excellent matrix material for the sustained delivery of drugs. Tablets prepared with tamarind kernel polysaccharide (TKP) as the sole matrix material could not provide sustained release of the incorporated ...
Arpita Saha, Kaushik Mukherjee, Bijaya Ghosh, Tapan Kumar Giri   +3 more
doaj   +1 more source