Results 21 to 30 of about 188,223,062 (256)

Identification of Maturity-Onset Diabetes of the Young Caused by Glucokinase Mutations Detected Using Whole-Exome Sequencing [PDF]

Endocrinology and Metabolism, 2017
Glucokinase maturity-onset diabetes of the young (GCK-MODY) represents a distinct subgroup of MODY that does not require hyperglycemia-lowering treatment and has very few diabetes-related complications. Three patients from two families who presented with
Eun-Hee Cho, Jae Woong Min, Sun Shim Choi, Hoon Sung Choi, Sang-Wook Kim   +4 more
doaj   +1 more source

Pregnancy outcome of Japanese patients with glucokinase–maturity‐onset diabetes of the young

Journal of Diabetes Investigation, 2019
Aims/Introduction Glucokinase–maturity‐onset diabetes of the young (GCK‐MODY; also known as MODY2) is a benign hyperglycemic condition, which generally does not require medical interventions.
Yuki Hosokawa, Shinji Higuchi, Rie Kawakita, Ikue Hata, Tatsuhiko Urakami, Tsuyoshi Isojima, Kei Takasawa, Yohei Matsubara, Haruo Mizuno, Yoshihiro Maruo, Katsuyuki Matsui, Katsuya Aizu, Kazuhiko Jinno, Shunsuke Araki, Yasuko Fujisawa, Koji Osugi, Chikako Tono, Yasuhiro Takeshima, Tohru Yorifuji   +18 more
doaj   +1 more source

Maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a long‐term diagnosis of type 1 diabetes

Journal of Diabetes Investigation, 2019
We report a case of missed diagnosis of maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a previous diagnosis of type 1 diabetes.
Mingqun Deng, Xiaojing Wang, Xinhua Xiao, Fan Ping   +3 more
doaj   +1 more source

Dorzagliatin, a dual-acting glucokinase activator, increases insulin secretion and glucose sensitivity in glucokinase-maturity-onset diabetes of the young (GCK-MODY) and recent-onset type 2 diabetes

, 2022
Glucokinase-maturity-onset diabetes of the young (GCK-MODY) is caused by heterozygous inactivating mutations in glucokinase (GK, gene symbol GCK) and impaired glucose sensing.
Li Chen (5749), Ronald CW Ma (8985394), Cadmon KP Lim (8985365), Sandra TF Tsoi (14007694), Ele Ferrannini (248028), Juliana CN Chan (8712420), Andrea Mari (297970), Ke Wang (82395), Andrea OY Luk (14007697), Elaine Chow (8473992), Baoqi Fan (8985353), Emily Poon (3525038)   +11 more
core   +1 more source

Genetic variants and characterization of MODY in a single, large pediatric referral center

Journal of Clinical & Translational Endocrinology
Background: Identifying Maturity-onset diabetes of the young (MODY) is essential as treatment differs from other forms of diabetes. Clinical characteristics and MODY probability calculator (MPC) scores were evaluated in patients with MODY.
Lily Deng, Amy S. Shah, Mansa Krishnamurthy   +2 more
doaj   +1 more source

Maturity-onset diabetes of the young and pregnancy

, 2023
Maturity-onset diabetes of the young (MODY) is a group of hereditary monogenetic forms of diabetes. MODY accounts for 1-3% of all persons with diabetes but is often undiagnosed or misdiagnosed as type 1 diabetes, type 2 diabetes, or gestational diabetes.
Thuesen, Anne Cathrine, Damm, Peter, Hansen, Torben, Kauffmann, Anna, Ringholm, Lene, Mathiesen, Elisabeth Reinhardt, Clausen, Tine Dalsgaard, Jørgensen, Isabella Lindegaard   +7 more
core   +1 more source

From Misdiagnosis to Precision: Genetic Testing Reveals MODY in Adolescents Initially Treated as Type 1 Diabetes [PDF]

Journal of Clinical and Diagnostic Research
Maturity-Onset Diabetes of the Young (MODY) is a heterogeneous form of clinical monogenic diabetes caused by genetic abnormalities resulting in an autosomal dominant mode of inheritance.
Kumar Ajith, Varalakshmi Sureka, J Jayannan, Purushothaman Indu   +3 more
doaj   +1 more source

Islet autoantibodies can discriminate maturity-onset diabetes of the young (MODY) from Type 1 diabetes

, 2011
AIM: Maturity-onset diabetes of the young is a monogenic form of familial, young-onset diabetes. It is rare (∼1% diabetes) and may be misdiagnosed as Type 1 diabetes and inappropriately treated with insulin.
Hattersley, AT, M. Shepherd, Shields, B, Shepherd, Maggie, Shields, Beverley, P. Bingley, Sian Ellard, A. Williams, McDonald, TJ, Bingley, P., Bingley, PJ, Williams, AJK, R. Brown, B. Shields, Hattersley, Andrew T., Brown, R. S., K. Colclough, Colclough, K, A. T. Hattersley, Williams, A. J., Brown, R, Colclough, K., T. J. McDonald, Ellard, S, Ellard, Sian, Shepherd, M, McDonald, Timothy J.   +26 more
core   +1 more source

High prevalence of maturity onset diabetes of the young (MODY) among Indians [PDF]

, 1985
This article describes the high prevalence of maturity-onset diabetes in the young (MODY) in an Indian clinic population of diabetic patients. MODY appears to be more common among Indians than among Caucasians.
Viswanathan, Moopil, Mohan, Rema, Mohan, Viswanathan, Ramachandran, Ambady, Snehalatha, Chamukuttan, Bharani, Gopalan   +5 more
core   +1 more source

Genotype, Phenotype, and Clinical Characteristics of Maturity-Onset Diabetes of the Young (MODY): Predominance of <i>GCK</i>-MODY [PDF]

J Clin Res Pediatr Endocrinol
Objective: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterised by early-onset diabetes and inherited in an autosomal dominant manner.
Kayaş L, Akıncı A, Çamtosun E, Dündar İ, Çiftçi N, Esener Z, Tekedereli İ, Doğan M.   +7 more
europepmc   +2 more sources