Results 121 to 130 of about 185,337,068 (295)

Characteristics of patients with diagnosis of maturity-onset diabetes of the young, according to the Russian diabetes registry

Сахарный диабет
BACKGROUND: Molecular genetic testing (MGT) is increasingly accessible, improving diagnosis of monogenic diabetes (DM), particularly maturity-onset diabetes of the young (MODY).
N. V. Rusyaeva, I. V. Kononenko, O. K. Vikulova, M. A. Isakov, M. V. Shestakova, N. G. Mokrysheva   +5 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Maturity-onset diabetes of the young with necrobiosis lipoidica and granuloma annulare

, 2006
We describe a 12-year-old white girl with granuloma annulare localized to both ankles since she was five, necrobiosis lipoidica in the left pretibial region since she was ten, and a recent history of weakness, migraine, and weight loss.
VENTURA, ALESSANDRO, MARCHETTI F, Elena Faleschini, TONINI G., Giorgio Tonini, GERARDUZZI T, FALESCHINI E, Tania Gerarduzzi, LONGO F, Federico Marchetti, Longo, Filippo, Gerarduzzi, Tania, Faleschini, Elena, Filippo Longo, Alessandro Ventura, Tonini, Giorgio, Marchetti, Federico   +16 more
core   +1 more source

Outcomes of patients with post‐stroke epilepsy: A scoping review on quality of life, readmissions, costs, seizure recurrence, and medication adherence

Epilepsia Open, EarlyView.
Abstract Objective Post‐stroke epilepsy (PSE) affects ≈10% of patients with stroke and is associated with adverse health and economic outcomes. We aimed to review published literature on health and economic outcomes for patients with PSE, with a specific focus on quality of life, hospital readmissions, healthcare costs, seizure recurrence, and ...
Nega Dagnew Baye, Emma Foster, Muideen T. Olaiya, Nigel C. Jones, Monique F. Kilkenny, Lachlan L. Dalli   +5 more
wiley   +1 more source

Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.

, 2007
An important question in human genetics is the extent to which genes causing monogenic forms of disease harbor common variants that may contribute to the more typical form of that disease.
Walker, Mark, Weedon, Michael N., Purcell, Shaun, Hitman, Graham, Winckler, Wendy, Bengtsson Boström, Kristina, Almgren, Peter,, Bengtsson Boström, Kristina,, Graham, Robert R., Gaudet, Daniel, Almgren, Peter, Frayling, Timothy M., Hirschhorn, Joel N., Hattersley, Andrew T., McCarrolll, Steven A., Groop, Leif, Daly, Mark J., McCarthy, Mark I., Ardlie, Kristin G., Lund University., Tuomi, Tiinamaija, Altshuler, David   +21 more
core   +1 more source

Examining the clinical and genetic spectrum of maturity-onset diabetes of the young (MODY) in Iran

Scientific Reports
Maturity-onset diabetes of the young (MODY) is an uncommon monogenic type of diabetes mellitus. Detecting genetic variants for MODY is a necessity for precise diagnosis and treatment.
Sara Asgarian, Hossein Lanjanian, Shiva Rahimipour Anaraki, Farzad Hadaegh, Maryam Moazzam-Jazi, Leila Najd-Hassan-Bonab, Sajedeh Masjoudi, Asiyeh Sadat Zahedi, Maryam Zarkesh, Bita Shalbafan, Mahdi Akbarzadeh, Sahand Tehrani Fateh, Davood Khalili, Amirabbas Momenan, Narges Sarbazi, Mehdi Hedayati, Fereidoun Azizi, Maryam S. Daneshpour   +17 more
doaj   +1 more source

Health Services Utilization by Individuals With Eating Disorders in Norway: A Nationwide Register‐Linkage Study

European Eating Disorders Review, EarlyView.
ABSTRACT Objective This study investigated healthcare utilization by individuals with an eating disorder (ED) stratified by age and ED diagnosis. Method Data were retrieved from the Norwegian Patient Registry (NPR) and the Control and Payment of Health Reimbursements (KUHR).
Anne Martina Kraus, Deborah Lynn Reas, Hege Marie Gjefsen, Øyvind Rø, Katrine Damgaard Skyrud   +4 more
wiley   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment

Diabetes, Metabolic Syndrome and Obesity, 2019
Tatsuhiko UrakamiDepartment of Pediatrics, Nihon University School of Medicine, Tokyo, JapanAbstract: Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant inheritance, onset before 25 years of age, absence of β-cell ...
Urakami T
doaj  

Case Report: long-term misdiagnosis and follow-up of a patient with HNF4A-MODY carrying a new de novo mutation

Frontiers in Endocrinology
BackgroundHNF4A-MODY constitutes 5%–10% of MODY cases; however, treatment options remain unclearly recommended, and long-term follow-up of patients with HNF4A-MODY is lacking due to limited research.
Jing Luo, Jing Luo, Ai Li, Ai Li, Xiaoli Wang   +4 more
doaj   +1 more source