Results 141 to 150 of about 19,208 (245)

Current evidence for a modulation of low back pain by human genetic variants [PDF]

open access: yes, 2009
The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle   +200 more
core   +1 more source

Polymorphisms in MC1R and ASIP Genes are Associated with Coat Color Variation in the Arabian Camel

open access: yesJournal of Heredity, 2018
Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes.
F. Almathen   +4 more
semanticscholar   +1 more source

Identification of MC1R SNPs and their Association with Plumage Colors in Asian Duck

open access: yesThe Journal of Poultry Science, 2017
The melanocortin 1 receptor (MC1R) gene is a candidate functional gene that controls the pigment production in melanocytes. The aim of this study was to identify polymorphisms and investigate the effect of the MC1R gene on plumage coloration in duck ...
Hasina Sultana   +8 more
doaj   +1 more source

Bird Integumentary Melanins: Biosynthesis, Forms, Function and Evolution [PDF]

open access: yes, 2016
Melanins are the ubiquitous pigments distributed in nature. They are one of the main pigments responsible for colors in living cells. Birds are among the most diverse animals regarding melanin-based coloration, especially in the plumage, although they ...
Agrup   +40 more
core   +2 more sources

Signatures of de-domestication in autochthonous pig breeds and of domestication in wild boar populations from MC1R and NR6A1 allele distribution.

open access: yesAnimal Genetics, 2019
Autochthonous pig breeds are usually reared in extensive or semi-extensive production systems that might facilitate contact with wild boars and, thus, reciprocal genetic exchanges. In this study, we analysed variants in the melanocortin 1 receptor (MC1R)
A. Ribani   +22 more
semanticscholar   +1 more source

SNP Miniplexes for Individual Identification of Random-Bred Domestic Cats. [PDF]

open access: yes, 2016
Phenotypic and genotypic characteristics of the cat can be obtained from single nucleotide polymorphisms (SNPs) analyses of fur. This study developed miniplexes using SNPs with high discriminating power for random-bred domestic cats, focusing on ...
Brooks, Ashley   +5 more
core   +2 more sources

Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties

open access: yesInternational Journal of Molecular Sciences, 2019
One of the first lines of cutaneous defense against photoaging is (a) the synthesis of melanin and (b) the initiation of an oxidative stress response to protect skin against the harmful effects of solar radiation.
E. Jackson   +5 more
semanticscholar   +1 more source

The Influence of MC1R Variants on Facial Aging Rate [PDF]

open access: yesJournal of Investigative Dermatology Symposium Proceedings, 2015
Aging of the skin is influenced both by intrinsic factors, such as chronological age, and by extrinsic or environmental factors, such as chronic ultraviolet exposure and smoking. Skin photoaging is defined as premature aging of the skin due to chronic sun exposure. Variation in human skin and hair color is due to differences in the absolute amounts and
openaire   +2 more sources

Epistatic interactions between at least three loci determine the “rat-tail” phenotype in cattle [PDF]

open access: yes, 2016
BACKGROUND: The “rat-tail” syndrome (RTS) is an inherited hypotrichosis in cattle, which is exclusively expressed in diluted coloured hair. The affected animals also suffer from disturbed thermoregulation, which impairs their health and growth ...
Christa Kuehn   +3 more
core   +6 more sources

Significance of the Melanocortin 1 and Endothelin B Receptors in Melanocyte Homeostasis and Prevention of Sun-Induced Genotoxicity

open access: yesFrontiers in Genetics, 2016
The membrane bound melanocortin 1 receptor (MC1R), and the endothelin B receptor (ENDBR) are two G-protein coupled receptors that play important roles in constitutive regulation of melanocytes and their response to ultraviolet radiation (UVR), the main ...
Zalfa A. Abdel-Malek, Viki Swope
doaj   +1 more source

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